Results 51 to 60 of about 103,948 (265)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Algorithms for computing QoS paths with restoration [PDF]
IEEE/ACM Transactions on Networking, 2003 There is a growing interest among service providers to offer new services with quality of service (QoS) guaranties that are also resilient to failures. Supporting QoS connections requires the existence of a routing mechanism, that computes the QoS paths, i.e., paths that satisfy QoS constraints (e.g., delay or bandwidth). Resilience to failures, on the
Yigal Bejerano +4 more
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Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
An Improved Physarum polycephalum Algorithm for the Shortest Path Problem
The Scientific World Journal, 2014 Shortest path is among classical problems of computer science. The problems are solved by hundreds of algorithms, silicon computing architectures and novel substrate, unconventional, computing devices. Acellular slime mould P.
Xiaoge Zhang +5 more
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On Computing the Path Number of a Graph
Electronic Notes in Theoretical Computer Science, 2019 Abstract Gallai (1966) conjectured that the edge set of every graph G on n vertices can be covered by at most ⌈n/2⌉ edge-disjoint paths. Such a covering by edge-disjoint paths is called a path decomposition, and the size of a path decomposition with a minimum number of elements is called the path number of G. Peroche (1984) proved that the problem of
Fábio Botler +2 more
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Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas +6 more
wiley +1 more source
Applied Sciences, 2022 Recent years have witnessed a paradigm shift from centralized cloud computing to decentralized edge computing. As a key enabler technique in edge computing, computation offloading migrates computation-intensive tasks from resource-limited devices to ...
Bo Xu +5 more
doaj +1 more source
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source