Results 41 to 50 of about 44,961 (259)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
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Temporal legacies of coal mining in the West Coast, New Zealand: path-dependency or path-creation?
Environmental Research: EnergyGlobal energy transition and decarbonisation efforts in the face of climate change present a new challenge for coal-based resource communities. While many resource-based communities and coal mining communities have become accustomed to the boom-bust ...
Sean Connelly, Etienne Nel, Alison Floyd
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Social History and Historical Sociology [PDF]
Historická sociologie, 2013 This paper deals with exchanges and misunderstandings between the German school of social history (most prominently represented by scholars from the University of Bielefeld (such as Hans-Ulrich Wehler) and Anglo-American trends in historical sociology ...
Wolfgang Knöbl
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Miscellanea Geographica: Regional Studies on Development, 2013 The aim of this study was to determine the conditions of sustainable (long-term) partnerships for the development of cross-border co-operation with regard to how they are formed and how they function.
Szmigiel-Rawska Katarzyna
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The 'Arc of Prosperity' Revisited: Homelessness Policy Change in North Western Europe
Social Inclusion, 2016 This paper compares continuity and change in homelessness policy in Ireland, Scotland and Norway with a particular focus on the period of post-crisis austerity measures (2008–2016).
Isobel Anderson +2 more
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
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FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
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Dados: Revista de Ciências Sociais, 2004 Dans cet article, on examine des approches actuelles sur les changements institutionnels et les innovations dans les politiques publiques, sous l'angle surtout de leurs processus de diffusion internationale.
Marcus André Melo
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