Results 51 to 60 of about 44,961 (259)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Critical Juncture of Unification - Window of (missed) opportunity for the German Welfare State?

Social Work and Society, 2013
The unification of West and East Germany posed tremendous challenges for the German welfare state. This paper conceptualizes this unification as a critical juncture in German history and critically explores the chosen path of institutional transfer of ...
Marlene Walk
doaj   +2 more sources

Smart working and digitalization of public administration. A transdisciplinary case study

Labour & Law Issues
This article analyses the relationship between digital transformation and remote work (lavoro agile) in the Italian Public Administration through a case study conducted within a large public organisation over the period from the outbreak of the Covid-19 ...
Pierluigi Digennaro
doaj   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Addiction Readiness in Adolescents: Role of Co-dependency, Interpersonal Cognitive Distortions, and Resilience [PDF]

Practice in Clinical Psychology
Objective: The present study examines the mediating role of resilience in the relationship between co-dependency and interpersonal cognitive distortions with addiction readiness in adolescents.
Vali Tavakoli Nia, Afsaneh Taheri, Nastaran Sharifi   +2 more
doaj  

Why fishers end up in social-ecological traps: a case study of Swedish eel fisheries in the Baltic Sea

Ecology and Society, 2020
Unsustainable fishing can be surprisingly persistent despite devastating social, economic, and ecological consequences. Sustainability science literature suggests that the persistence of unsustainable fisheries can be understood as a social-ecological ...
Emma Björkvik, Wiebren J. Boonstra, Jonas Hentati-Sundberg   +2 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Du carbon lock-in au nuclear lock-in : les verrous spatiaux aux changements de politique nucléaire en Suède

Développement Durable et Territoires, 2017
Energy geographers have shown that the difficulty encountered by modern societies to decrease their fossil fuel consumption could be explained by the influence of spatial path dependencies, also called carbon lock-in.
Teva Meyer
doaj   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source