Results 51 to 60 of about 1,364,358 (297)
Miscellanea Geographica: Regional Studies on Development, 2013 The aim of this study was to determine the conditions of sustainable (long-term) partnerships for the development of cross-border co-operation with regard to how they are formed and how they function.
Szmigiel-Rawska Katarzyna
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
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Temporal legacies of coal mining in the West Coast, New Zealand: path-dependency or path-creation?
Environmental Research: EnergyGlobal energy transition and decarbonisation efforts in the face of climate change present a new challenge for coal-based resource communities. While many resource-based communities and coal mining communities have become accustomed to the boom-bust ...
Sean Connelly, Etienne Nel, Alison Floyd
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The 'Arc of Prosperity' Revisited: Homelessness Policy Change in North Western Europe
Social Inclusion, 2016 This paper compares continuity and change in homelessness policy in Ireland, Scotland and Norway with a particular focus on the period of post-crisis austerity measures (2008–2016).
Isobel Anderson +2 more
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
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Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
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Dados: Revista de Ciências Sociais, 2004 Dans cet article, on examine des approches actuelles sur les changements institutionnels et les innovations dans les politiques publiques, sous l'angle surtout de leurs processus de diffusion internationale.
Marcus André Melo
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FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
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Improving dependency label accuracy using statistical post-editing: A cross-framework study [PDF]
, 2011 We present a statistical post-editing method for modifying the dependency labels in a dependency analysis. We test the method using two English datasets, three parsing systems and three labelled dependency schemes.
Foster, Jennifer +3 more
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Critical Juncture of Unification - Window of (missed) opportunity for the German Welfare State?
Social Work and Society, 2013 The unification of West and East Germany posed tremendous challenges for the German welfare state. This paper conceptualizes this unification as a critical juncture in German history and critically explores the chosen path of institutional transfer of ...
Marlene Walk
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