Results 61 to 70 of about 7,100 (249)

Intestinal Microbiota Composition of Interleukin-10 Deficient C57BL/6J Mice and Susceptibility to Helicobacter hepaticus-Induced Colitis [PDF]

, 2013
The mouse pathobiont Helicobacter hepaticus can induce typhlocolitis in interleukin-10-deficient mice, and H. hepaticus infection of immunodeficient mice is widely used as a model to study the role of pathogens and commensal bacteria in the pathogenesis ...
A Burich, A Giongo, A Klindworth, A Mangerich, Achim D. Gruber, AK Benson, André Bleich, Birgit Brenneke, Christine Josenhans, Daniel Eibach, DN Frank, E Elinav, E Pruesse, EJ Baron, EV Kulagina, FE Dewhirst, Friederike Kops, G Büchler, H Ochman, Ines Yang, J Chow, J Vaahtovuo, JA Peña, James G. Fox, Jessika Schulze, JG Fox, JG Fox, JG Fox, JL Lofgren, JM Ward, JR White, JS Pratt, K Katoh, KJ Maloy, L Bartonickova, LA Dieleman, M Ciszek-Lenda, M Hoffmann, M Rajilić-Stojanović, Markus M. Heimesaat, MC Kullberg, MC Kullberg, MC Kullberg, MK Friswell, MR Hufeldt, MSP Azevedo, MT Whary, N Segata, PB Eckburg, PD Schloss, PD Schloss, PJ Turnbaugh, Q Wang, RC Edgar, RC Edgar, RJ Cahill, S Devkota, S Finegold, S Nell, S Suerbaum, Sabrina Woltemate, Sebastian Suerbaum, SK Mazmanian, SR Boutin, SR Boutin, Sureshkumar Muthupalani, T Kuehbacher, T Sterzenbach, T Sterzenbach, UK Schumacher, VB Young, W Jia, W Nicklas, WS Garrett, Y Cai, Y Liu, Z Ge, Z Ge, Z Ge, Z Ge, Z Ge, Z Zhang   +81 more
core   +3 more sources

The role of diet in the aetiopathogenesis of inflammatory bowel disease [PDF]

, 2018
Crohn’s disease and ulcerative colitis, collectively known as IBD, are chronic inflammatory disorders of the gastrointestinal tract. Although the aetiopathogenesis of IBD is largely unknown, it is widely thought that diet has a crucial role in the ...
A Ascherio, A Caspi, A Charlebois, A Ferguson, A Finamore, A Franke, A Poullis, A Racine, A Spor, A Tragnone, A Zhernakova, AL Hernandez, AL Kau, AN Ananthakrishnan, AN Ananthakrishnan, AN Ananthakrishnan, AN Ananthakrishnan, AN Ananthakrishnan, Andrew R. Hart, Andrew T. Chan, AP Simopoulos, AR Hart, AS Prasad, Ashwin N. Ananthakrishnan, B Khor, C Filippo De, C Tysk, C Wu, C Yuan, CA Chapman-Kiddell, CE Hargreaves, CN Williams, CS Probert, D Bharadwaj, D Feskanich, D Kevans, D Kevans, D Knights, DJ Hunter, DJ Hunter, E Bettelli, E Degagne, E Giovannucci, E Riboli, E Rimm, EE Kenny, EI Benchimol, EP Halmos, GA Colditz, GD Wu, GR D’Haens, H Khalili, H Khalili, H Sokol, Hamed Khalili, HE Seifried, HR Rockett, HR Rockett, I Costea, I Ordás, I Romieu, IBD in EPIC Study Investigators, IW Kim, J Breton, J Burisch, J Liang, JL Opstelten, JS Gavaler, K Brown, KW Sloot Van Der, L Zhou, LG Albenberg, LK Stenman, LL Barton, L A David, M Kleinewietfeld, M Martinez-Medina, M Zachos, MC Fantini, MD Kappelman, MD Kappelman, MJ Bonder, MM Bergmann, MM Bergmann, MP Stein, MP Stein, N Ijssennagger, N Ijssennagger, N Risch, N Yosef, N., I. J., NA Molodecky, NA Nagalingam, O Borrelli, P Ferrari, P Jantchou, Paul Lochhead, PC Calder, PG Persson, PJ Turnbaugh, R Eil, RK Leu Le, RK Sellon, S Bao, S Devkota, S Kugathasan, SC Ng, Simon S. M. Chan, SJ London, SS Chan, SS Chan, SS Seregin, T Hudcovic, T Longobardi, T Werner, T Yamamoto, VA Leone, W Turpin, WC Willett, WC Willett, WC Zhang, X Li, XC Morgan   +122 more
core   +1 more source

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

Full-length 16S rRNA nanopore sequencing enables species resolution of Fusobacterium associated with colorectal cancer

Gut Microbes
Recent studies have revealed that the long-recognized link between the historically defined Fusobacterium nucleatum group and colorectal cancer is largely driven by Fusobacterium animalis.
William Rosenbaum, Marina Rubio Garcia, Anna Löfgren-Burström, Pär Larsson, Sofia Edin, Vicky Bronnec, Richard Palmqvist   +6 more
doaj   +1 more source

Diet, microbes, and host genetics: the perfect storm in inflammatory bowel diseases [PDF]

, 2014
The incidence of inflammatory bowel diseases (IBD), as well as other inflammatory conditions, has dramatically increased over the past half century. While many studies have shown that IBD exhibits a genetic component via genome-wide association studies ...
Chang, Eugene B., Devkota, Suzanne, Leone, Vanessa   +2 more
core   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Metagenomic data from cerebrospinal fluid permits tracing the origin and spread of Neisseria meningitidis CC4821 in China

Communications Biology, 2022
Metagenomic data from cerebrospinal fluid was used to genotype Neisseria meningitidis in patients with invasive meningococcal disease and trace the origin of the pathobiont, providing a phylogeographic analysis of the strain’s evolution in China and its ...
Hongbin Chen, Mei Li, Shangyu Tu, Xiaoyang Zhang, Xiaojuan Wang, Yawei Zhang, Chunjiang Zhao, Yinghui Guo, Hui Wang   +8 more
doaj   +1 more source

Tilivalline- and Tilimycin-Independent Effects of Klebsiella oxytoca on Tight Junction-Mediated Intestinal Barrier Impairment [PDF]

, 2019
Klebsiella oxytoca causes antibiotic-associated hemorrhagic colitis and diarrhea. This was attributed largely to its secreted cytotoxins tilivalline and tilimycin, inductors of epithelial apoptosis.
Bücker, Roland, Fromm, Anja, Fromm, Michael, Gorkiewicz, Gregor, Hering, Nina A., Högenauer, Christoph, Schulzke, Jörg-Dieter, Troeger, Hanno, Zechner, Ellen   +8 more
core   +1 more source

Enzymatic Basis for the Oxidative Branch of Aromatic Amino Acid Fermentation Leading to p‐cresol Formation

Advanced Science, EarlyView.
In anaerobic bacteria, tyrosine serves as an electron donor in the oxidative Stickland fermentation branch, generating p‐hydroxyphenylacetate, ATP and reduced ferredoxin for decarboxylation into p‐cresol. ABSTRACT The phenolic metabolite p‐cresol is a byproduct of tyrosine fermentation by certain strictly anaerobic bacteria, including the human gut ...
Li Jiang, Yifeng Wei, Xumei Liu, Dazhi Liu, Zhenyu Liu, Yang Tong, Jinyu Yin, Ankanahalli N. Nanjaraj Urs, Meining Xing, Mark A. Harrison, Chuyuan Zhang, Sheng Yang, Yunzi Luo, Ee Lui Ang, Huimin Zhao, Yan Zhang   +15 more
wiley   +1 more source

Advanced Dental Composite Technology via Bisilanized Dual‐Action Nanofillers for Biofilm Control

Advanced Science, EarlyView.
A multimodal research strategy has led to the development of an innovative resin‐based composite (RBC) with dual antibacterial action. The S_CM‐RBC formula showed strong antibiofilm activity, excellent mechanical strength, and biosafety. It effectively controlled oral bacteria in prevention of caries recurrence, and maintained pulp health in a rat ...
Chenmin Yao, Line Etiennot, Naiera Zayed, Shengjie Liang, Mehraveh Saghi, Jelle Verdonck, Lingyue Liu, Fei Zhang, Wim Teughels, Cui Huang, Kirsten Van Landuyt, Bart Van Meerbeek   +11 more
wiley   +1 more source