Results 81 to 90 of about 4,917 (252)

Acute Infectious Gastroenteritis Potentiates a Crohn's Disease Pathobiont to Fuel Ongoing Inflammation in the Post-Infectious Period.

, 2016
Crohn's disease (CD) is a chronic inflammatory condition of diverse etiology. Exposure to foodborne pathogens causing acute gastroenteritis produces a long-term risk of CD well into the post-infectious period but the mechanistic basis for this ongoing ...
Joseph B McPhee, Brian K Coombes, Cherrie L Small, Lydia Xing, Hong T Law   +4 more
core   +1 more source

Associations Between Microbial Depletion and Autonomic Dysregulation in Binge‐Eating Disorder

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective The interplay between the gut microbiome and autonomic nervous system remains unexplored in binge‐eating disorder (BED). We aimed to explore specific microbial alterations in BED and examine their potential association with cardiac vagal tone as a distinct bio‐behavioral phenotype.
Shuang Liang, Esben Strodl, Leanne Barron, Matthew Bambling, Luis Vitetta   +4 more
wiley   +1 more source

Construction of Chronic Kidney Disease Mouse Model Induced by Diets With Different Adenine Content

Food Safety and Health, EarlyView.
By administering a 4 weeks adenine diet to C57BL/6J mice, we identified 0.2% adenine in purified feed as the optimal chronic kidney disease model. This model induces severe renal damage, gut dysbiosis, uremic toxin accumulation, and CKD mineral bone disorder, providing a clinically relevant platform for mechanistic and therapeutic studies.
Wanjun Liao, Jiayao Wang, Yilian Huang, Na Zhang, Xiaodan Shi, Zongcai Tu, Zuohua Xie, Tao Yuan, Hongmei Yin   +8 more
wiley   +1 more source

Dynamic interactions between the oral pathobiont Campylobacter concisus and the human gut microbiota [PDF]

Microbiology Australia
The human gut microbiota is a highly dynamic ecosystem in which commensal, opportunistic and pathogenic microorganisms interact to influence the host’s physiology and disease risk.
Pradip Sedhai, Taghrid Istivan
doaj   +1 more source

Disease Features and Gastrointestinal Microbial Composition in Patients with Systemic Sclerosis from Two Independent Cohorts

ACR Open Rheumatology, 2022
Objective The study objective was to examine alterations in gastrointestinal (GI) microbial composition in patients with systemic sclerosis (SSc) and to investigate the relationship between SSc features and GI microbiota using two independent ...
Kristofer Andréasson, S. Melanie Lee, Venu Lagishetty, Meifang Wu, Natalie Howlett, James English, Roger Hesselstrand, Philip J. Clements, Jonathan P. Jacobs, Elizabeth R. Volkmann   +9 more
doaj   +1 more source

Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response [PDF]

Trends in Immunology, 2014
Recent studies have uncovered novel mechanisms underlying the breakdown of periodontal host-microbe homeostasis, which can precipitate dysbiosis and periodontitis in susceptible hosts. Dysbiotic microbial communities of keystone pathogens and pathobionts are thought to exhibit synergistic virulence whereby not only can they endure the host response but
openaire   +2 more sources

Effects of a gut pathobiont in a gnotobiotic mouse model of childhood undernutrition [PDF]

Science Translational Medicine, 2016
Pathobiont-associated cachexia in a gnotobiotic model of childhood undernutrition is determined by strain-level interactions within the gut microbiota.
Wagner, Vitas E, Dey, Neelendu, Guruge, Janaki, Hsiao, Ansel, Ahern, Philip P, Semenkovich, Nicholas P, Blanton, Laura V, Cheng, Jiye, Griffin, Nicholas, Stappenbeck, Thaddeus S, Ilkayeva, Olga, Newgard, Christopher B, Petri, William, Haque, Rashidul, Ahmed, Tahmeed, Gordon, Jeffrey I   +15 more
openaire   +4 more sources

Antibiotic-Induced Pathobiont Dissemination Accelerates Mortality in Severe Experimental Pancreatitis

, 2017
Although antibiotic-induced dysbiosis has been demonstrated to exacerbate intestinal inflammation, it has been suggested that antibiotic prophylaxis may be beneficial in certain clinical conditions such as acute pancreatitis (AP).
Luciano P. Silva, Laura Gehrke, André Báfica, Flávia C. Amaral, Fernanda S. Soares, Matheus R. Valente, Lívia H. Yamashiro, Raphael G. Ferreira, Mara C. Scheffer, José C. Alves-Filho, Fernando Spiller, Lorena K. R. Santos, Fernanda V. E. S. Castanheira, Natália L. C. Silva   +13 more
core   +1 more source

Macrophage extracellular vesicles deliver Mef2d proteins to aggravate Bacteroides fragilis pathogenicity in type 2 diabetes arterial calcification

Interdisciplinary Medicine, EarlyView.
Bacteroides fragilis is associated with type 2 diabetes (T2D) arterial calcification and can be activated by macrophage‐derived extracellular vesicles (EVs). BF takes up EVs via receptor‐mediated endocytosis, and activation is induced by EV‐derived Mef2d, thereby inhibiting ArsR family transcriptional regulator transcription.
Cong Chen, Rong He, Jirong Luo, Zhengfeng Liang, Qunwen Pan, Shuangquan Liu, Jingsong Cao   +6 more
wiley   +1 more source

An IBD-associated pathobiont synergises with NSAID to promote colitis which is blocked by NLRP3 inflammasome and Caspase-8 inhibitors

, 2023
Conflicting evidence exists on the association between consumption of non-steroidal anti-inflammatory drugs (NSAIDs) and symptomatic worsening of inflammatory bowel disease (IBD).
Raminder Singh, Adam Clooney, Valerio Rossini, Tanya D’ Souza, Fergus Shanahan, Stephen R. Stockdale, Colin Hill, Stefan Andersson-Engels, Gonzalo Saiz-Gonzalo, Silvia Melgar, Naomi Hanrahan, Ken Nally, Lorraine A. Draper   +12 more
core   +1 more source