Results 81 to 90 of about 5,803 (234)

Identification of a Czc-like operon of the periodontal pathobiont Porphyromonas gingivalis involved in metal ion efflux [PDF]

, 2023
Objective The study aimed to investigate the role of the PGN2012 gene of the periodontitis contributing pathobiont Porphyromonas gingivalis. PGN2012 is a homolgue of TolC and is a gene our group previously showed was overexpressed in hyperinvasive ...
Lambert, D.W., Stafford, G.P., Gains, A.F., D.W. Lambert, A.F. Gains, G.P. Stafford   +5 more
core   +1 more source

Metagenomic data from cerebrospinal fluid permits tracing the origin and spread of Neisseria meningitidis CC4821 in China

Communications Biology, 2022
Metagenomic data from cerebrospinal fluid was used to genotype Neisseria meningitidis in patients with invasive meningococcal disease and trace the origin of the pathobiont, providing a phylogeographic analysis of the strain’s evolution in China and its ...
Hongbin Chen, Mei Li, Shangyu Tu, Xiaoyang Zhang, Xiaojuan Wang, Yawei Zhang, Chunjiang Zhao, Yinghui Guo, Hui Wang   +8 more
doaj   +1 more source

Beyond antimicrobials: Ecological nano‐strategies for rebalancing dysbiotic oral microbial homeostasis

BMEMat, EarlyView.
Oral microbial homeostasis, a dynamic host‐microbe balance, is vital in infectious diseases. Conventional antibiotics often disrupt this homeostasis, spurring interest in nanomaterials for oral microbial homeostasis rebalancing. This review outlines nanomaterial strategies across three ecological levels (population/community, ecosystem, and cross ...
Chen Hu, Aohan Luan, Yujun Yang, Linlin Wang, Huilin Wang, Ning Wang, Guixin He, Yajie Yang, Rabiya Noor, Jawad Hussain, Longquan Shao   +10 more
wiley   +1 more source

Prognostic Role of Porphyromonas gingivalis Gingipain Rgp and Matrix Metalloproteinase 9 in Oropharyngeal Squamous Cell Carcinoma [PDF]

, 2022
Background/Aim: The oral bacteria involved in the development of periodontitis alter the tissue conditions and modify immune responses in a way that may also influence tumor development.
Kylmä, Anna Kaisa, Jouhi, Lauri, Mäkitie, Antti, Sorsa, Timo, Mohamed, Hesham, Hagström, Jaana, Atula, Timo, Randen-Brady, Reija, Haglund, Caj, Mustonen, Harri K.   +9 more
core   +1 more source

The gut microbiome and drug‐resistant epilepsy: Microbiome–antiseizure medication interactions and implications for pharmacoresistance

Epilepsia Open, EarlyView.
Abstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Khaled Zammar, Majd A. AbuAlrob, Musab Ali, Simona Lattanzi, Boulenouar Mesraoua   +4 more
wiley   +1 more source

Mirroring Amino Acids Hold Sway to Scare Pathobionts Away

Cellular and Molecular Gastroenterology and Hepatology, 2023
Editorial Material ; International ...
Denizot, Jeremy, Chassaing, Benoit
openaire   +4 more sources

Case-Control Microbiome Study of Chronic Otitis Media with Effusion in Children Points at Streptococcus salivarius as a Pathobiont-Inhibiting Species [PDF]

, 2021
: Chronic otitis media with effusion (OME) has been associated with a shift in microbiome composition and microbial interaction in the upper respiratory tract (URT).
J\uf6rissen, Jennifer, An Boudewyns, Vedat Topsakal, Vincent Van Rompaey, Topsakal, Vedat, Marianne F. L. van den Broek, Liesbet Van Heirstraeten, Van de Heyning, Paul, Wouters, Ine, Sarah Lebeer, Jennifer Jörissen, Van Beeck, Wannes, Olivier M. Vanderveken, Van Rompaey, Vincent, Theeten, Heidi, Wannes Van Beeck, Heidi Theeten, Surbi Malhotra-Kumar, Vanderveken, Olivier M., Stijn Wittouck, Ilke De Boeck, van Heirstraeten, Liesbet, Boudewyns, An, Pierre Van Damme, Wittouck, Stijn, van Damme, Pierre, De Boeck, Ilke, Ine Wouters, Lebeer, Sarah, Paul Van de Heyning, Malhotra-Kumar, Surbhi, Jorissen, Jennifer, van den Broek, Marianne F.L., Malhotra-Kumar, Surbi, Jennifer J\uf6rissen   +34 more
core   +1 more source

Parvimonas micra and central nervous system infections: mechanisms of transformation from oral commensal to intracranial pathogen and clinical evidence

Frontiers in Cellular and Infection Microbiology
Parvimonas micra (P. micra), an anaerobic oral coccus long dismissed as a culture contaminant, is increasingly recognized as a causative agent of pyogenic central nervous system (CNS) infections, yet its neuropathogenesis remains poorly defined.
Cancan Gong, Xubo Jing, Shanwei Jiang, Chaoxiao Yu   +3 more
doaj   +1 more source

Aggregatibacter Actinomycetemcomitans : Clinical Significance of a Pathobiont Subjected to Ample Changes in Classification and Nomenclature

, 2019
Aggregatibacter actinomycetemcomitans is a Gram-negative bacterium that is part of the oral microbiota. The aggregative nature of this pathogen or pathobiont is crucial to its involvement in human disease.
Claesson, Rolf, Höglund Åberg, Carola, Anne Birkeholm Jensen, Claesson, Rolf,, Haubek, Dorte, Carola Höglund Åberg, Höglund Åberg, Carola,, Nørskov-Lauritsen, Niels, Rolf Claesson, Jensen, Anne Birkeholm, Niels Nørskov-Lauritsen, Dorte Haubek   +11 more
core   +1 more source

Addressing the Abundance Paradox Through Topology‐Guided Graph Learning for Cross‐Cohort Classification of Type 2 Diabetes

iMetaMed, EarlyView.
By shifting from highly variable taxonomic abundance to conserved ecological network topologies, our Dual‐Stream Graph Attention Network (DS‐GAT‐CP) resolves the “abundance paradox,” enabling highly accurate and cross‐regionally robust non‐invasive screening for Type 2 Diabetes. ABSTRACT Gut microbiome‐based machine learning models for Type 2 Diabetes (
Changjian Wu, Ping Wei, Xuhui Wang, Hua Hua, Junli Li   +4 more
wiley   +1 more source