Results 101 to 110 of about 4,917 (252)

Case-control microbiome study of chronic otitis media with effusion in children points at Streptococcus salivarius as a pathobiont-inhibiting species

, 2021
: Chronic otitis media with effusion (OME) has been associated with a shift in microbiome composition and microbial interaction in the upper respiratory tract (URT).
J\uf6rissen, Jennifer, An Boudewyns, Vedat Topsakal, Vincent Van Rompaey, Topsakal, Vedat, Marianne F. L. van den Broek, Liesbet Van Heirstraeten, Van de Heyning, Paul, Wouters, Ine, Sarah Lebeer, Jennifer Jörissen, Van Beeck, Wannes, Olivier M. Vanderveken, Van Rompaey, Vincent, Theeten, Heidi, Wannes Van Beeck, Heidi Theeten, van den Broek, Marianne, Surbi Malhotra-Kumar, Vanderveken, Olivier M., Stijn Wittouck, Ilke De Boeck, van Heirstraeten, Liesbet, Boudewyns, An, Pierre Van Damme, Wittouck, Stijn, van Damme, Pierre, De Boeck, Ilke, Ine Wouters, Malhotra, Surbhi, Lebeer, Sarah, Paul Van de Heyning   +31 more
core   +1 more source

Periodontitis during pregnancy: The effect on the gut microbiome and intestinal inflammation

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis has been epidemiologically associated with adverse pregnancy outcomes, but causality remains difficult to establish in humans due to confounding factors. This study uses a controlled murine model to examine the effects of experimentally induced periodontitis on the composition of the gut microbiota and gastrointestinal
Richard Bright, Matthew G. Macowan, Keyuan Tian, Tracy Fitzsimmons, Rebecca L. Wilson, Claire T. Roberts, Claus T. Christophersen, Peter M. Bartold, Stephen P. Kidd, Peter S. Zilm   +9 more
wiley   +1 more source

Microbial burden of periodontal diseases and its clinical application: The stage, grade, and furcation matter

Journal of Periodontology, EarlyView.
Abstract Background Periodontal diseases are associated with dysbiotic oral microbial communities, but clinically applicable measures that reflect microbial burden across disease severity and progression remain limited. This study aimed to assess the oral microbial burden of periodontal diseases by evaluating salivary and subgingival lipopolysaccharide
Anbo Dong, Susanna Paju, Jaakko Leskelä, Muhammed Manzoor, Jukka Putaala, Pauli Ylikotila, Eija Könönen, Pirkko Pussinen, Svetislav Zaric   +8 more
wiley   +1 more source

Klebsiella ARO112 promotes microbiota recovery, pathobiont clearance and prevents inflammation in IBD mice

Precise microbiota modulation towards improving immune function and metabolic homeostasis is a major goal in clinical research. It is also critical for reducing pathogen invasion or pathobiont expansion, contributors to epidemic Inflammatory Bowel ...
García-Garcerá, Marc, Cabral, Vitor, Ubeda, Carles, Correia, Margarida B, Pedro, Miguel F, Oliveira, Rita A, Xavier, Karina B   +6 more
core   +1 more source

Oral PHGG ameliorates atopic dermatitis‐like dermatitis with concurrent modulation of colonic IgA and cecal microbiota: implications for the gut–skin axis

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Atopic dermatitis (AD) is increasingly recognized as a systemic inflammatory disorder linked to intestinal immune and microbiome dysregulation. However, whether dietary galactomannan fibers can mitigate AD through coordinated modulation of the gut–skin axis remains unexplored.
Derrick Kakooza, Hyeonjun Yu, Jonghyun Jeong, Jung Cheul Shin, Woo Jung Kim, Sung‐Kwon Moon, Hoon Kim   +6 more
wiley   +1 more source

Biochemical characterization of the Escherichia coli surfaceome: a focus on type I fimbriae and flagella

Frontiers in Microbiology
The Escherichia coli surfaceome consists mainly of the large surface organelles expressed by the organism to navigate and interact with the surrounding environment. The current study focuses on type I fimbriae and flagella.
Devon W. Kavanaugh, Adeline Sivignon, Yannick Rossez, Zina Chouit, Christophe Chambon, Christophe Chambon, Louane Béal, Mathilde Bonnet, Michel Hébraud, Michel Hébraud, Yann Guérardel, Hang Thi Thu Nguyen, Nicolas Barnich   +12 more
doaj   +1 more source

The Impact of Gene Dosage and Heterozygosity on the Diploid Pathobiont Candida albicans

, 2019
Candida albicans is a fungal species that can colonize multiple niches in the human host where it can grow either as a commensal or as an opportunistic pathogen. The genome of C.
Shen-Huan Liang, Richard J. Bennett
core   +1 more source

Correlation Between Gut Microbiota, Metabolites, and Diabetic Complications: A Two‐Sample Mendelian Randomization Study

Medicine Advances, EarlyView.
Fang et al. demonstrate a significant causal relationship among gut microbiota, gut metabolites, and diabetic complications, highlighting a biological link underlying mechanisms of diabetic vascular diseases. These findings provide important implications for future therapeutic strategy and risk prediction.
Jiaxi Fang, Leilei Zhai, Chan Huang, Liqin Li, Yong Wang, Jiaojiao Fan, Wei Zhou   +6 more
wiley   +1 more source

Betulinic Acid Enema Alleviates Colitis by Targeting Vitamin D Receptor to Protect the Intestinal Mucosal Barrier and Modulate Mucosa‐Associated Microbiota

Phytotherapy Research, EarlyView.
ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with limited effectiveness and safety of current drug therapies. Betulinic acid (BA) is a naturally occurring pentacyclic triterpenoid present in traditional Chinese medicines used clinically as retention enemas for UC, but its direct effects and mechanisms remain unclear ...
Lina Dong, Yuanxia Gao, Qian Li, Guangxin Chen, Dong Yang, Liping Zhao, Xiaojing Liu, Shumei Lin   +7 more
wiley   +1 more source

Image_4_Absence of Bacteria Permits Fungal Gut-To-Brain Translocation and Invasion in Germfree Mice but Ageing Alone Does Not Drive Pathobiont Expansion in Conventionally Raised Mice.tif

, 2022
Age-associated changes in the structure of the intestinal microbiome and in its interaction with the brain via the gut-brain axis are increasingly being implicated in neurological and neurodegenerative diseases.
Andrew Goldson (9608858), Catherine Purse (13109145), Aimée Parker (573329), Arlaine Brion (9608855), David Baker (11642), Steve A. James (13109142), Andrea Telatin (5665339), Simon R. Carding (8409225)   +7 more
core   +1 more source