Results 101 to 110 of about 5,803 (234)

Betulinic Acid Enema Alleviates Colitis by Targeting Vitamin D Receptor to Protect the Intestinal Mucosal Barrier and Modulate Mucosa‐Associated Microbiota

Phytotherapy Research, EarlyView.
ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with limited effectiveness and safety of current drug therapies. Betulinic acid (BA) is a naturally occurring pentacyclic triterpenoid present in traditional Chinese medicines used clinically as retention enemas for UC, but its direct effects and mechanisms remain unclear ...
Lina Dong, Yuanxia Gao, Qian Li, Guangxin Chen, Dong Yang, Liping Zhao, Xiaojing Liu, Shumei Lin   +7 more
wiley   +1 more source

Oral Microalgae‐Laden Hydrogels Modulating the Intestinal Microbiota Metabolism for Acute Alcohol‐Induced Liver Injury Therapy

Small, EarlyView.
A food‐grade microalgae‐laden hydrogel (FMH) enables efficient in situ microalgae cultivation and serves as an oral therapeutic platform for acute alcohol‐induced liver injury. FMH improves alcohol tolerance, alleviates oxidative stress, inflammation, and lipid metabolic disorders, restores gut microbial homeostasis, and provides synergistic ...
Zhixin Hu, Hongtao Wu, Xuanqi Liu, Xinxu Huang, Linli Jiang, Lei Liu, Xiaojie Li, Yawen Yao, Fengzheng Gao, Kui Zeng, Jiajing Zhou   +10 more
wiley   +1 more source

An IBD-associated pathobiont synergises with NSAID to promote colitis which is blocked by NLRP3 inflammasome and Caspase-8 inhibitors

, 2023
Conflicting evidence exists on the association between consumption of non-steroidal anti-inflammatory drugs (NSAIDs) and symptomatic worsening of inflammatory bowel disease (IBD).
Raminder Singh, Adam Clooney, Valerio Rossini, Tanya D’ Souza, Fergus Shanahan, Stephen R. Stockdale, Colin Hill, Stefan Andersson-Engels, Gonzalo Saiz-Gonzalo, Silvia Melgar, Naomi Hanrahan, Ken Nally, Lorraine A. Draper, Draper, Lorraine A, Singh, Raminder, Andersson-Engels, Stefan, Nally, Ken, Saiz-Gonzalo, Gonzalo, Hanrahan, Naomi, Hill, Colin, Melgar, Silvia, Stockdale, Stephen R, Shanahan, Fergus, Clooney, Adam, Rossini, Valerio, D' Souza, Tanya   +25 more
core   +1 more source

Effect of the microbiome on pathogen susceptibility across four Drosophilidae species

Insect Science, EarlyView.
Four Drosophilidae species were used to investigate how variation in the host microbiome influences susceptibility to infection. Microbial composition and abundance differed among species and treatments. The effects of microbiome manipulation on host survival were both species‐ and pathogen‐specific.
Hongbo Sun, Ben Longdon, Ben Raymond
wiley   +1 more source

Draft Genome Sequence of Lactobacillus brevis Strain EW, a Drosophila Gut Pathobiont

, 2013
Lactobacillus brevis strain EW, a gut pathobiont, was isolated from the fruit flyDrosophila melanogaster. Here, we report the draft genome sequence of L.
Young Min Park, Eun-kyoung Kim, Oun Young Lee, Won-jae Lee   +3 more
core  

Antibiotic-Induced Pathobiont Dissemination Accelerates Mortality in Severe Experimental Pancreatitis

, 2017
Although antibiotic-induced dysbiosis has been demonstrated to exacerbate intestinal inflammation, it has been suggested that antibiotic prophylaxis may be beneficial in certain clinical conditions such as acute pancreatitis (AP).
Luciano P. Silva, Laura Gehrke, André Báfica, Flávia C. Amaral, Fernanda S. Soares, Matheus R. Valente, Lívia H. Yamashiro, Raphael G. Ferreira, Mara C. Scheffer, José C. Alves-Filho, Fernando Spiller, Lorena K. R. Santos, Fernanda V. E. S. Castanheira, Natália L. C. Silva   +13 more
core   +1 more source

Transcriptome profiling of human col\onic cells exposed to the gut pathobiont Streptococcus gallolyticus subsp. gallolyticus

, 2023
International audienceStreptococcus gallolyticus sp . gallolyticus (SGG) is a gut pathobiont involved in the development of colorectal cancer (CRC). To decipher SGG contribution in tumor initiation and/or acceleration respectively, a global transcriptome
Trieu-Cuot, Patrick, Rachel Legendre, Patrick Trieu-Cuot, Ewa Pasquereau-Kotula, Hugo Varet, Sismeiro, Odile, Dramsi, Shaynoor, Pasquereau-Kotula, Ewa, Shaynoor Dramsi, Laurence du Merle, Du Merle, Laurence, Legendre, Rachel, Odile Sismeiro, Varet, Hugo, Pietrosemoli, Natalia, Natalia Pietrosemoli   +15 more
core   +1 more source

IgE‐Binding Bacterial Components Not Yet Documented in the Allergen Databases and Their Allergenic Mechanisms: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Among bacteria that are associated with the development and/or exacerbation of allergic/atopic diseases, several have been described to produce IgE‐binding components. However, only one bacterial protein, Bac s 1, is currently listed in the official database of the World Health Organization/International Union of Immunological Societies (WHO ...
Uta Jappe, Marua Abu Risha, Ioana Agache, Claus Bachert, Barbara Bröker, Riccardo Castagnoli, Gabriele Gadermaier, Richard E. Goodman, Amir Guemari, Christiane Hilger, Alain Jacquet, Sabine Kespohl, Ludger Klimek, Annette Kuehn, Jonas Lidholm, Vera Mahler, Markus Ollert, Thomas A. Platts‐Mills, Monika Raulf, Peter Schmid‐Grendelmeier, Frieder Schmiedeke, Marianne van Hage, Joana Vitte, Josefina Zakzuk, Anna Pomés   +24 more
wiley   +1 more source

Ulcerative Colitis-associated E. coli pathobionts potentiate colitis in susceptible hosts

Gut Microbes, 2020
Ulcerative colitis (UC) is a chronic inflammatory condition linked to intestinal microbial dysbiosis, including the expansion of E. coli strains related to extra-intestinal pathogenic E. coli.
Hyungjun Yang, Hengameh Chloé Mirsepasi-Lauridsen, Carsten Struve, Joannie M. Allaire, Adeline Sivignon, Wayne Vogl, Else S. Bosman, Caixia Ma, Abbas Fotovati, Gregor S. Reid, Xiaoxia Li, Andreas Munk Petersen, Sébastien G. Gouin, Nicolas Barnich, Kevan Jacobson, Hong Bing Yu, Karen Angeliki Krogfelt, Bruce A. Vallance   +17 more
doaj   +1 more source

Distinct Microbial and Host Proteome Signatures Relate to Proteolytic Activity in Gingival Crevicular Fluid in an Exploratory Study of Patients With Periodontitis

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim Risk assessment tools for periodontitis lack sufficient precision to predict disease progression. The aim of this exploratory study was to evaluate proteolytic activity (PA) in gingival crevicular fluid in relation to clinically assessed progression risk, microbial community composition and host proteome. Materials and Methods Samples were
Miguel Carda‐Diéguez, Stefan Rüdiger, Gunnel Svensäter, Henrik Jansson, Tirthankar Mohanty, Yashuan Chao, Christofer Karlsson, Johan Malmström, Oonagh Shannon, Álex Mira, Julia R. Davies   +10 more
wiley   +1 more source