Results 121 to 130 of about 4,917 (252)

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

GAS Regulation of Zinc Homeostasis During Skin and Soft Tissue Infection

Proceedings
Streptococcus pyogenes (Group A Streptococcus, GAS) is an enigmatic human-restricted pathobiont, capable of both colonization and infection [...]
Reid Wilkening, Lindsey Burcham, Laura Cook, Alexander Horswill   +3 more
doaj   +1 more source

Distinct Campylobacter fetus lineages adapted as livestock pathogens and human pathobionts in the intestinal microbiota

Nature Communications, 2017
Human infections with Campylobacter fetus are often assumed to be derived from livestock. Here, Iraola et al. provide evidence that healthy humans may act as carriers and dispersers, and C.
Gregorio Iraola, Samuel C. Forster, Nitin Kumar, Philippe Lehours, Sadjia Bekal, Francisco J. García-Peña, Fernando Paolicchi, Claudia Morsella, Helmut Hotzel, Po-Ren Hsueh, Ana Vidal, Simon Lévesque, Wataru Yamazaki, Claudia Balzan, Agueda Vargas, Alessandra Piccirillo, Bonnie Chaban, Janet E. Hill, Laura Betancor, Luis Collado, Isabelle Truyers, Anne C. Midwinter, Hatice T. Dagi, Francis Mégraud, Lucía Calleros, Ruben Pérez, Hugo Naya, Trevor D. Lawley   +27 more
doaj   +1 more source

Beneficial Oral Biofilms as Smart Bioactive Interfaces

Frontiers in Microbiology, 2018
Periodontitis is a very common health problem caused by formation of pathogenic bacterial biofilm that triggers inflammation resulting in either reversible gingivitis or irreversible periodontal hard and soft tissue damages, leading to loss of teeth when
Beatrice Gutt, Qun Ren, Irmgard Hauser-Gerspach, Piotr Kardas, Stefan Stübinger, Monika Astasov-Frauenhoffer, Tuomas Waltimo   +6 more
doaj   +1 more source

Characterizing arginine, ornithine, and putrescine pathways in enteric pathobionts

MicrobiologyOpen
AbstractArginine‐ornithine metabolism plays a crucial role in bacterial homeostasis, as evidenced by numerous studies. However, the utilization of arginine and the downstream products of its metabolism remain undefined in various gut bacteria. To bridge this knowledge gap, we employed genomic screening to pinpoint relevant metabolic targets.
Ian M. Lillie, Charles E. Booth, Adelaide E. Horvath, Matthew Mondragon, Melinda A. Engevik, Thomas D. Horvath   +5 more
openaire   +3 more sources

mTOR pathway interaction with gut microbiome and pathobiont during aging from mechanistic view: evidence from Appling exercise, probiotics, Vitamin D and Leucine in rodents

<p>mTOR, as an anabolic hub, integrates several various signals and controls cell survival. In aging, it becomes overactive but protein synthesis doesn't increase parallel to this issue.
Mohabbat, Majid
core   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Innovative functional characterization of the pro-inflammatory pathobiont Escherichia coli adherent and invasive pathobiont (AIEC).

, 2023
Le pathobionte Escherichia coli adhérent et invasif (AIEC) a été identifié avec une prévalence plus élevée chez les patients atteints de maladies inflammatoires chroniques de l'intestin (MICI). Les AIEC sont définis par leur capacité à (i) envahir les cellules épithéliales intestinales, (ii) survivre dans les macrophages (iii) sans marqueur génétique ...
openaire   +1 more source

The Oral‐Gut Axis: Bidirectional Interactions Between Microbiome and Diseases

Journal of Periodontal Research, EarlyView.
This study aims to summarize the mechanisms underlying ectopic colonization of the gut by oral pathobionts and the microbial and host factors that regulate this process. ABSTRACT Increased colonization of typically oral microorganisms is frequently observed in the gut mucosa or lumen of individuals with gastrointestinal disorders, including patients ...
Shinya Ebihara, Nobuhiko Kamada
wiley   +1 more source

Periodontitis and Inflammatory Bowel Diseases: Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review aims to provide a conceptual framework for understanding the mechanistic interplay between periodontitis and IBD, with a particular emphasis on the microbial and immunological crosstalk linking the oral cavity and the gastrointestinal tract.
Ana Paula V. Colombo, Adriana M. de Oliveira, Nobuhiko Kamada, Sho Kitamoto   +3 more
wiley   +1 more source