Results 111 to 120 of about 5,803 (234)

The Immunobiological Path and Fate of the Human Intestinal Allergens and Pathobiont Translocation

The immune system and the microbiome are in a lifelong co-partnership. Symbiotic microbiome is coexisted with normal immune homeostasis while dysbiotic microbiome associated with immune dyseegulation.
Ibrahim MS Shnawa
core   +1 more source

CVID enteropathy is characterized by exceeding low mucosal IgA levels and interferon-driven inflammation possibly related to the presence of a pathobiont [PDF]

, 2018
Common variable immunodeficiency (CVID), the most common symptomatic primary antibody deficiency, is accompanied in some patients by a duodenal inflammation and malabsorption syndrome known as CVID enteropathy (E-CVID).The goal of this study was to ...
Sosnovtsev, Stanislav, Quezado, Martha, Dong, Xiaoxi, Strober, Warren, Vyshenska, Dariia, Fuss, Ivan J, Montgomery-Recht, Kim, Greer, Renee L, Morgun, Andrey, Yao, Michael, Shulzhenko, Natalia, Vasquez-Perez, Stephany, Gurung, Manoj, Peremyslova, Ekaterina   +13 more
core   +1 more source

The Causal Effect of Supra‐ and Sub‐Gingival Instrumentation on the Oral Microbiome of Elderly Periodontitis Patients Treated in Nursing Homes: Secondary Analysis of a Randomised Controlled Trial

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aims Periodontitis among nursing home residents is increasing as more older adults retain their dentition. Evidence on the impact of periodontal therapy on their oral microbiota is limited. We aimed to assess the effect of outreach‐based supra‐ and sub‐gingival instrumentation on the periodontal microbiome.
Anna Greta Barbe, Daniel Hagenfeld, Carolin Walther, Dalia Beck, Fedja Farowski, Maria J. G. T. Vehreschild, Sonja H. M. Derman, Sven Kleine Bardenhorst, Dirk Bleiel   +8 more
wiley   +1 more source

Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10−/− mice [PDF]

, 2012
The composite human microbiome of Western populations has probably changed over the past century, brought on by new environmental triggers that often have a negative impact on human health.
Vanessa Leone, Devkota, Suzanne, Fehlner-Peach, Hannah, Dionysios A. Antonopoulos, Bana Jabri, Jabri, Bana, Anuradha Nadimpalli, Hannah Fehlner-Peach, Leone, Vanessa, Suzanne Devkota, Yunwei Wang, Antonopoulos, Dionysios A, Nadimpalli, Anuradha, Chang, Eugene B, Wang, Yunwei, Mark W. Musch, Musch, Mark W, Eugene B. Chang   +17 more
core   +1 more source

Biochemical characterization of the Escherichia coli surfaceome: a focus on type I fimbriae and flagella

Frontiers in Microbiology
The Escherichia coli surfaceome consists mainly of the large surface organelles expressed by the organism to navigate and interact with the surrounding environment. The current study focuses on type I fimbriae and flagella.
Devon W. Kavanaugh, Adeline Sivignon, Yannick Rossez, Zina Chouit, Christophe Chambon, Christophe Chambon, Louane Béal, Mathilde Bonnet, Michel Hébraud, Michel Hébraud, Yann Guérardel, Hang Thi Thu Nguyen, Nicolas Barnich   +12 more
doaj   +1 more source

Hidradenitis suppurativa skin microbiome: In‐depth analysis and modulation by systemic therapies

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Hidradenitis suppurativa skin exhibits profound dysbiosis, characterized by the depletion of homeostatic commensals and expansion of anaerobic pathogens. Longitudinal evaluation reveals that while systemic antibiotics successfully reverse HS dysbiosis, biologics (adalimumab and secukinumab) fail to clear pathogens despite clinical healing.
Yacine Amar, Diana Baumann, Sebastian Niedermeier, Rafaela L. Silva, Susanne Walch, Michael Schloter, Martin Köberle, Tilo Biedermann, Thomas Volz   +8 more
wiley   +1 more source

mTOR pathway interaction with gut microbiome and pathobiont during aging from mechanistic view: evidence from Appling exercise, probiotics, Vitamin D and Leucine in rodents

<p>mTOR, as an anabolic hub, integrates several various signals and controls cell survival. In aging, it becomes overactive but protein synthesis doesn't increase parallel to this issue.
Mohabbat, Majid
core   +1 more source

The Role of Viruses in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the presence and potential pathogenic role of viruses in periodontitis. Design: Narrative Review; Population: Patients with periodontitis; Exposure: Detection of viruses in oral samples (biopsies, saliva, gingival crevicular fluid, subgingival plaque, blood); Outcome: Viral prevalence, load ...
Kim Natalie Stolte, Jørgen Slots, Henrik Dommisch   +2 more
wiley   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

The Keystone‐Pathogen Hypothesis Updated: The Role of Porphyromonas gingivalis in Periodontitis

Journal of Periodontal Research, EarlyView.
Porphyromonas gingivalis orchestrates a coordinated manipulation of immune and inflammatory responses in periodontal tissues which leads to the generation of a dysbiotic, subgingival biofilm community, and progression of periodontitis. The type 9 secretion system, lipid A modification, and the formation of outer membrane vesicles are important ...
Mike A. Curtis, James A. Garnett, Richard P. Darveau   +2 more
wiley   +1 more source