Results 91 to 100 of about 4,917 (252)

Multi‐omics biomarkers for intestinal infection and inflammation in inflammatory bowel disease: Current evidence, translational challenges, and diagnostic opportunities

Interdisciplinary Medicine, EarlyView.
Prospective multi‐site cohorts, multi‐omics profiling, and computational analysis may help identify biomarker patterns across clinical settings in IBD and superimposed infections. With further mechanistic and clinical validation, these signals could support the development of practical multi‐analyte tools for more precise diagnosis and management ...
Ziyu Yang, Jiayi Yao, Xinxian Zhao, Yan Xu, Yifan Chen, Tianchi Chen, Ying Jian, Min Li   +7 more
wiley   +1 more source

A murine model of adult gastrointestinal colonization by Group B Streptococcus

Infection and Immunity
Group B Streptococcus (Streptococcus agalactiae, GBS) is a leading cause of invasive infections in neonates and adults. The adult gastrointestinal (GI) tract represents an understudied site of asymptomatic carriage with potential relevance for both ...
Joie Ling, Luke R. Joyce, Kelly S. Doran, Andrew J. Hryckowian   +3 more
doaj   +1 more source

CVID enteropathy is characterized by exceeding low mucosal IgA levels and interferon-driven inflammation possibly related to the presence of a pathobiont [PDF]

, 2019
Common variable immunodeficiency (CVID), the most common symptomatic primary antibody deficiency, is accompanied in some patients by a duodenal inflammation and malabsorption syndrome known as CVID enteropathy (E-CVID).The goal of this study was to ...
Sosnovtsev, Stanislav, Quezado, Martha, Dong, Xiaoxi, Strober, Warren, Vyshenska, Dariia, Fuss, Ivan J, Montgomery-Recht, Kim, Greer, Renee L, Morgun, Andrey, Yao, Michael, Shulzhenko, Natalia, Vasquez-Perez, Stephany, Gurung, Manoj, Peremyslova, Ekaterina   +13 more
core   +1 more source

Electrolyzed saline as an alternative to chlorhexidine: Antimicrobial and biofilm volume outcomes in a 4‐day non‐brushing randomized controlled clinical trial

Journal of Periodontology, EarlyView.
Abstract Background The biofilm‐inhibitory effects of electrolyzed saline (EOS) vary widely due to differences in formulations and treatment methods. This study analyzed the impact of EOS on key oral microbial species and used serial 3D‐intraoral scans to evaluate its effects on de novo biofilm formation.
Katja Povšič, Haris Munjaković, Naiera Zayed, Wim Teughels, Katja Seme, Aleš Fidler, Rok Gašperšič   +6 more
wiley   +1 more source

Ulcerative Colitis-associated E. coli pathobionts potentiate colitis in susceptible hosts

Gut Microbes, 2020
Ulcerative colitis (UC) is a chronic inflammatory condition linked to intestinal microbial dysbiosis, including the expansion of E. coli strains related to extra-intestinal pathogenic E. coli.
Hyungjun Yang, Hengameh Chloé Mirsepasi-Lauridsen, Carsten Struve, Joannie M. Allaire, Adeline Sivignon, Wayne Vogl, Else S. Bosman, Caixia Ma, Abbas Fotovati, Gregor S. Reid, Xiaoxia Li, Andreas Munk Petersen, Sébastien G. Gouin, Nicolas Barnich, Kevan Jacobson, Hong Bing Yu, Karen Angeliki Krogfelt, Bruce A. Vallance   +17 more
doaj   +1 more source

Mice harboring pathobiont-free microbiota do not develop intestinal inflammation that normally results from an innate immune deficiency

, 2018
BackgroundInability to maintain a stable and beneficial microbiota is associated with chronic gut inflammation, which classically manifests as colitis but may more commonly exist as low-grade inflammation that promotes metabolic syndrome.
Andrew T. Gewirtz (308724), Andrew T Gewirtz, Andrew T. Gewirtz, Benoit Chassaing (209607), Benoit Chassaing   +4 more
core   +1 more source

A Pathobiont of the Mammalian Microbiota Balances Intestinal Inflammation and Colonization [PDF]

, 2011
Humans and mammals are colonized by a multitude of microbial organisms that have co‐evolved with their hosts for millions of years. The majority of these microbes reside in the gastrointestinal (GI) tract as a complex and dynamic consortium.
Chow, Janet
core   +1 more source

Measurement of association and co-occurrence of the prevalence of pathobionts and risk alleles with the clinical features in patients with CD.

, 2021
A) Association measurement between and amongst pathobiont prevalence (noted as ‘Positive’ and ‘Negative’ for each pathobiont type) and the clinical features of the patients with CD using Goodman and Kruskal’s Tau association; B) Association measurement ...
Aditya Bajaj (11292495), Mahak Verma (11292498), Manasvini Markandey (11292492), Baibaswata Nayak (292413), Imteyaz Ahmad Khan (11292489), Saurabh Kedia (2576857), Sambudhha Kumar (11292501), Mukesh Kumar Singh (788270), Vineet Ahuja (705730)   +8 more
core   +1 more source

Mapping the subgingival HerBiome and HisBiome over the human healthspan

Journal of Periodontology, EarlyView.
Abstract Background Understanding the intricate relationship between sex, age, and the oral microbiome is crucial for deciphering the onset and progression of numerous age‐related oral and systemic diseases. Methods Subgingival plaque was collected from 781 periodontally and systemically healthy females and 160 males spanning 0 to 80 years.
Rahul Nikam, Kazune Pax, Michelle Lee‐Scott Beverly, Purnima S. Kumar   +3 more
wiley   +1 more source

Role of Autoimmune Susceptibility Gene, PTPN2, in Mediating Host-Pathobiont Interaction [PDF]

, 2023
The intestinal epithelium acts as a physical barrier between the luminal microbes and the immune cells in the lamina propria while also coordinating a very delicate equilibrium to maintain mucosal homeostasis.
Chatterjee, Pritha
core