NLRP6 Protects Il10−/− Mice from Colitis by Limiting Colonization of Akkermansia muciniphila
Cell Reports, 2017 Dysfunction in host immune responses and pathologic alterations in the gut microbiota, referred to as dysbiosis, can both contribute to the development of inflammatory bowel disease (IBD). However, it remains unclear how specific changes in host immunity
Sergey S. Seregin +11 more
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Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota. [PDF]
, 2014 Periodontitis has been implicated as a risk factor for metabolic disorders such as type 2 diabetes, atherosclerotic vascular diseases, and non-alcoholic fatty liver disease. Although bacteremias from dental plaque and/or elevated circulating inflammatory
Arimatsu, Kei +10 more
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The adherent/invasive escherichia coli (AIEC) strain LF82 invades and persists in human prostate cell lineRWPE-1 activating a strong inflammatory response [PDF]
, 2016 Adherent/invasive Escherichia coli (AIEC) strains have recently been receiving increased attention because they are more prevalent and persistent in the intestine of Crohn's disease (CD) patients than in healthy subjects.
ALEANDRI, MARTA +13 more
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Frontiers in Veterinary Science, 2021 Porcine proliferative enteropathy remains one of the most prevalent diseases in swine herds worldwide. This disease is caused by Lawsonia intracellularis, an intracellular bacterial pathogen that primarily colonizes the ileum. In this study, we evaluated
Fernando L. Leite +9 more
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Intestinal epithelial PTPN2 limits pathobiont colonization by immune-directed antimicrobial responses [PDF]
Gut MicrobesPritha Chatterjee +2 more
exaly +2 more sources
The Role of Butyrate in Attenuating Pathobiont-Induced Hyperinflammation
Immune Network, 2020 An excessive hyperinflammatory response-caused septic shock is a major medical problem that is associated with pathogenic bacterial infections leading to high mortality rates. The intestinal microbiota and the associated elaborated metabolites such as short chain fatty acid butyrate have been shown to relieve pathogenic bacterial-caused acute ...
Jiezhong Chen, Luis Vitetta
openaire +2 more sources
A systematic approach to cancer: evolution beyond selection. [PDF]
, 2017 Cancer is typically scrutinized as a pathological process characterized by chromosomal aberrations and clonal expansion subject to stochastic Darwinian selection within adaptive cellular ecosystems.
Miller, William B, Torday, John S
core +1 more source
Frontiers in Pediatrics, 2018 The illness ME/CFS has been repeatedly tied to infectious agents such as Epstein Barr Virus. Expanding research on the human microbiome now allows ME/CFS-associated pathogens to be studied as interacting members of human microbiome communities.
Amy Proal, Trevor Marshall
doaj +1 more source
The Complete Genome Sequence of the Murine Pathobiont Helicobacter typhlonius [PDF]
Frontiers in Microbiology, 2016 Immuno-compromised mice infected with Helicobacter typhlonius are used to model microbially inducted inflammatory bowel disease (IBD). The specific mechanism through which H. typhlonius induces and promotes IBD is not fully understood. Access to the genome sequence is essential to examine emergent properties of this organism, such as its pathogenicity.
Jeroen eFrank +10 more
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Galleria mellonella: A Novel Invertebrate Model to Distinguish Intestinal Symbionts From Pathobionts
Frontiers in Immunology, 2018 Insects and mammals share evolutionary conserved innate immune responses to maintain intestinal homeostasis. We investigated whether the larvae of the greater wax moth Galleria mellonella may be used as an experimental organism to distinguish between ...
Anna Lange +6 more
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