Results 41 to 50 of about 5,803 (234)

NLRP6 Protects Il10−/− Mice from Colitis by Limiting Colonization of Akkermansia muciniphila

Cell Reports, 2017
Dysfunction in host immune responses and pathologic alterations in the gut microbiota, referred to as dysbiosis, can both contribute to the development of inflammatory bowel disease (IBD). However, it remains unclear how specific changes in host immunity
Sergey S. Seregin, Natasha Golovchenko, Bryan Schaf, Jiachen Chen, Nicholas A. Pudlo, Jonathan Mitchell, Nielson T. Baxter, Lili Zhao, Patrick D. Schloss, Eric C. Martens, Kathryn A. Eaton, Grace Y. Chen   +11 more
doaj   +1 more source

The Cynomolgus Macaque Intestinal Mycobiome Is Dominated by the Kazachstania Genus and K. pintolopesii Species

Journal of Fungi, 2022
The cynomolgus macaque, Macaca fascicularis, is a non-human primate (NHP) widely used in biomedical research as its genetics, immunology and physiology are similar to those of humans.
Steve A. James, Aimee Parker, Catherine Purse, Andrea Telatin, David Baker, Sandy Holmes, James Durham, Simon G. P. Funnell, Simon R. Carding   +8 more
doaj   +1 more source

The Role of Butyrate in Attenuating Pathobiont-Induced Hyperinflammation

Immune Network, 2020
An excessive hyperinflammatory response-caused septic shock is a major medical problem that is associated with pathogenic bacterial infections leading to high mortality rates. The intestinal microbiota and the associated elaborated metabolites such as short chain fatty acid butyrate have been shown to relieve pathogenic bacterial-caused acute ...
Jiezhong Chen, Luis Vitetta
openaire   +2 more sources

Die Kämpfe únd schláchten—the struggles and battles of innate-like effector T lymphocytes with microbes

Frontiers in Immunology, 2023
The large majority of lymphocytes belong to the adaptive immune system, which are made up of B2 B cells and the αβ T cells; these are the effectors in an adaptive immune response.
Sebastian Joyce, Sebastian Joyce, Gosife Donald Okoye, John P. Driver   +3 more
doaj   +1 more source

Hepatic Branch Vagotomy Modulates the Gut-Liver-Brain Axis in Murine Cirrhosis

Frontiers in Physiology, 2021
BackgroundCirrhosis and hepatic encephalopathy (HE) are linked with an altered gut-liver-brain axis, however, the relative contribution of hepatic vagal innervation is unclear.
Yuan Zhang, Jason D. Kang, Derrick Zhao, Siddartha S. Ghosh, Yanyan Wang, Yunling Tai, Javier Gonzalez-Maeso, Masoumeh Sikaroodi, Patrick M. Gillevet, H. Robert Lippman, Phillip B. Hylemon, Huiping Zhou, Jasmohan S. Bajaj   +12 more
doaj   +1 more source

Gut microbiota and pathobiont exposure influences disease incidence in non-obese diabetic mice. [PDF]

Front Microbiol
While the non-obese diabetic (NOD) mouse is the most widely used animal model of type 1 diabetes (T1D), it suffers from poor reproducibility in disease incidence often attributed to variables in the environment, including the gut ...
Russell AL, Olthoff B, Zhang C, Lutz C, Franklin CL, Ericsson AC.   +5 more
europepmc   +2 more sources

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in the Era of the Human Microbiome: Persistent Pathogens Drive Chronic Symptoms by Interfering With Host Metabolism, Gene Expression, and Immunity

Frontiers in Pediatrics, 2018
The illness ME/CFS has been repeatedly tied to infectious agents such as Epstein Barr Virus. Expanding research on the human microbiome now allows ME/CFS-associated pathogens to be studied as interacting members of human microbiome communities.
Amy Proal, Trevor Marshall
doaj   +1 more source

A Pathobiont of the Microbiota Balances Host Colonization and Intestinal Inflammation [PDF]

Cell Host & Microbe, 2010
The gastrointestinal tract harbors a diverse microbiota that has coevolved with mammalian hosts. Though most associations are symbiotic or commensal, some resident bacteria (termed pathobionts) have the potential to cause disease. Bacterial type VI secretion systems (T6SSs) are one mechanism for forging host-microbial interactions.
Chow, Janet, Mazmanian, Sarkis K.
openaire   +4 more sources

Data_Sheet_2_Adherent-invasive E. coli – induced specific IgA limits pathobiont localization to the epithelial niche in the gut.PDF

, 2023
Background and aimAdherent-invasive E. coli (AIEC) has been identified as a pathobiont associated with Crohn’s disease (CD), that prefers to grow in inflammatory conditions.
Karl Bil Eap (14666579), Tatehiro Kagawa (3403346), Sho Kitamoto (120436), Nicolas Barnich (277067), Masashi Matsushima (14666591), Hiroko Nagao-Kitamoto (14666588), Masashi Ohno (2729473), Takayoshi Suzuki (172609), Kohei Sugihara (14666585), Jin Imai (12253907), Yasuhiro Nishizaki (13868637), Katsuto Hozumi (6686363), Rika Tanaka (1281948), Masaki Yazawa (12253910), Hidekazu Suzuki (105870), Hitoshi Tsugawa (296864), Nobuhiko Kamada (505070), Motoki Kaneko (14666582)   +17 more
core   +1 more source

Galleria mellonella: A Novel Invertebrate Model to Distinguish Intestinal Symbionts From Pathobionts

Frontiers in Immunology, 2018
Insects and mammals share evolutionary conserved innate immune responses to maintain intestinal homeostasis. We investigated whether the larvae of the greater wax moth Galleria mellonella may be used as an experimental organism to distinguish between ...
Anna Lange, Andrea Schäfer, Annika Bender, Alexander Steimle, Sina Beier, Raphael Parusel, Julia-Stefanie Frick   +6 more
doaj   +1 more source