Results 31 to 40 of about 4,917 (252)

Comparative analysis of the red-complex organisms and recently identified periodontal pathogens in the subgingival plaque of diabetic and nondiabetic patients with severe chronic periodontitis

Journal of Indian Society of Periodontology, 2023
Aim: This analytical case–control study sought to evaluate the presence of the recently established putative periodontal pathogen organisms, Filifactor alocis and Fretibacterium fastidiosum, against the levels of the already established red-complex ...
Divya Shree Pandian, Dhayanad John Victor, Priyanka Cholan, P SG Prakash, Sangeetha Subramanian, Sumi Priyadarshini Shankar   +5 more
doaj   +1 more source

A Hen in the Wolf Den: A Pathobiont Tale [PDF]

Immunity, 2018
Disruption of the gut microbiota is thought to contribute to disease onset in individuals with a genetic predisposition to autoimmunity. In a recent issue of Science, Manfredo Vieira et al. (2018) identify translocation of the gut commensal Enterococcus gallinarum into the liver as a trigger for the autoimmune disease systemic lupus erythematous.
Matteo M, Guerrini, Alexis, Vogelzang, Sidonia, Fagarasan   +2 more
openaire   +2 more sources

Sequestration of gut pathobionts in intraluminal casts, a mechanism to avoid dysregulated T cell activation by pathobionts

Proceedings of the National Academy of Sciences, 2022
T cells that express the transcription factor RORγ, regulatory (Treg), or conventional (Th17) are strongly influenced by intestinal symbionts. In a genetic approach to identify mechanisms underlying this influence, we performed a screen for microbial genes implicated, in germfree mice monocolonized with Escherichia coli
Sassone-Corsi, Martina, Azriel, Shalhevet, Simon, Ariel, Ramanan, Deepshika, Ortiz-Lopez, Adriana, Chen, Felicia, Yissachar, Nissan, Mathis, Diane, Benoist, Christophe   +8 more
openaire   +2 more sources

Histogram of the number of assigned pathobiont simulated reads.

, 2022
Histogram showing the read count frequency of true positive (blue) and false positive (red) pathobiont reads as identified by HAYSTAC and HOPS, after screening 200 spiked iterations of an ancient Oral Microbiome dataset sample (anc200e2repgn).
Evangelos A. Dimopoulos (4373215), Christina Warinner (513402), Alberto Carmagnini (13889699), Laurent A. F. Frantz (13889705), Evan K. Irving-Pease (4998092), Irina M. Velsko (13889702), Greger Larson (42564)   +6 more
core   +1 more source

A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation

Hepatology, EarlyView., 2022
In this study of the gut mucosal microbiota in primary sclerosing cholangitis (PSC), we found consistent microbiota features associated with PSC and recurrent PSC, PSC with inflammatory bowel disease and a persistent gut dysbiosis after liver transplantation Abstract Background and Aims Several characteristic features of the fecal microbiota have been ...
Mikal Jacob Hole, Kristin Kaasen Jørgensen, Kristian Holm, Peder R. Braadland, Malin Holm Meyer‐Myklestad, Asle Wilhelm Medhus, Dag Henrik Reikvam, Alexandra Götz, Krzysztof Grzyb, Kirsten Muri Boberg, Tom Hemming Karlsen, Martin Kummen, Johannes R. Hov   +12 more
wiley   +1 more source

Proinflammatory and Cancer-Promoting Pathobiont Fusobacterium nucleatum Directly Targets Colorectal Cancer Stem Cells [PDF]

, 2022
Intestinal bacterial communities participate in gut homeostasis and are recognized as crucial in bowel inflammation and colorectal cancer (CRC). Fusobacterium nucleatum (Fn), a pathobiont of the oral microflora, has recently emerged as a CRC-associated ...
Bachrach G., Delogu G., Maulucci G., Mercuri A., Bianchetti G., Fidaleo M., Pani G., Emoli V., Masi L., Cavallucci V., Palucci I., Fiori M. E., Scaldaferri F.   +12 more
core   +3 more sources

The Cynomolgus Macaque Intestinal Mycobiome Is Dominated by the Kazachstania Genus and K. pintolopesii Species

Journal of Fungi, 2022
The cynomolgus macaque, Macaca fascicularis, is a non-human primate (NHP) widely used in biomedical research as its genetics, immunology and physiology are similar to those of humans.
Steve A. James, Aimee Parker, Catherine Purse, Andrea Telatin, David Baker, Sandy Holmes, James Durham, Simon G. P. Funnell, Simon R. Carding   +8 more
doaj   +1 more source

Die Kämpfe únd schláchten—the struggles and battles of innate-like effector T lymphocytes with microbes

Frontiers in Immunology, 2023
The large majority of lymphocytes belong to the adaptive immune system, which are made up of B2 B cells and the αβ T cells; these are the effectors in an adaptive immune response.
Sebastian Joyce, Sebastian Joyce, Gosife Donald Okoye, John P. Driver   +3 more
doaj   +1 more source

NLRP6 Protects Il10−/− Mice from Colitis by Limiting Colonization of Akkermansia muciniphila

Cell Reports, 2017
Dysfunction in host immune responses and pathologic alterations in the gut microbiota, referred to as dysbiosis, can both contribute to the development of inflammatory bowel disease (IBD). However, it remains unclear how specific changes in host immunity
Sergey S. Seregin, Natasha Golovchenko, Bryan Schaf, Jiachen Chen, Nicholas A. Pudlo, Jonathan Mitchell, Nielson T. Baxter, Lili Zhao, Patrick D. Schloss, Eric C. Martens, Kathryn A. Eaton, Grace Y. Chen   +11 more
doaj   +1 more source

Data_Sheet_1_Adherent-invasive E. coli – induced specific IgA limits pathobiont localization to the epithelial niche in the gut.PDF

, 2023
Background and aimAdherent-invasive E. coli (AIEC) has been identified as a pathobiont associated with Crohn’s disease (CD), that prefers to grow in inflammatory conditions.
Karl Bil Eap (14666579), Tatehiro Kagawa (3403346), Sho Kitamoto (120436), Nicolas Barnich (277067), Masashi Matsushima (14666591), Hiroko Nagao-Kitamoto (14666588), Masashi Ohno (2729473), Takayoshi Suzuki (172609), Kohei Sugihara (14666585), Jin Imai (12253907), Yasuhiro Nishizaki (13868637), Katsuto Hozumi (6686363), Rika Tanaka (1281948), Masaki Yazawa (12253910), Hidekazu Suzuki (105870), Hitoshi Tsugawa (296864), Nobuhiko Kamada (505070), Motoki Kaneko (14666582)   +17 more
core   +1 more source