Results 21 to 30 of about 5,803 (234)

Control of pathogens and pathobionts by the gut microbiota [PDF]

Nature Immunology, 2013
A dense resident microbial community in the gut, referred as the commensal microbiota, coevolved with the host and is essential for many host physiological processes that include enhancement of the intestinal epithelial barrier, development of the immune system and acquisition of nutrients.
Nobuhiko, Kamada, Grace Y, Chen, Naohiro, Inohara, Gabriel, Núñez   +3 more
openaire   +2 more sources

Sequestration of gut pathobionts in intraluminal casts, a mechanism to avoid dysregulated T cell activation by pathobionts

Proceedings of the National Academy of Sciences, 2022
T cells that express the transcription factor RORγ, regulatory (Treg), or conventional (Th17) are strongly influenced by intestinal symbionts. In a genetic approach to identify mechanisms underlying this influence, we performed a screen for microbial genes implicated, in germfree mice monocolonized with ...
Sassone-Corsi, Martina, Azriel, Shalhevet, Simon, Ariel, Ramanan, Deepshika, Ortiz-Lopez, Adriana, Chen, Felicia, Yissachar, Nissan, Mathis, Diane, Benoist, Christophe   +8 more
openaire   +2 more sources

Dietary Emulsifiers Directly Impact Adherent-Invasive E. coli Gene Expression to Drive Chronic Intestinal Inflammation

Cell Reports, 2020
Summary: Dietary emulsifiers carboxymethylcellulose (CMC) and polysorbate-80 (P80) disturb gut microbiota, promoting chronic inflammation. Mice with minimal microbiota are protected against emulsifiers’ effects, leading us to hypothesize that these ...
Emilie Viennois, Alexis Bretin, Philip E. Dubé, Alexander C. Maue, Charlène J.G. Dauriat, Nicolas Barnich, Andrew T. Gewirtz, Benoit Chassaing   +7 more
doaj   +1 more source

A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation

Hepatology, EarlyView., 2022
In this study of the gut mucosal microbiota in primary sclerosing cholangitis (PSC), we found consistent microbiota features associated with PSC and recurrent PSC, PSC with inflammatory bowel disease and a persistent gut dysbiosis after liver transplantation Abstract Background and Aims Several characteristic features of the fecal microbiota have been ...
Mikal Jacob Hole, Kristin Kaasen Jørgensen, Kristian Holm, Peder R. Braadland, Malin Holm Meyer‐Myklestad, Asle Wilhelm Medhus, Dag Henrik Reikvam, Alexandra Götz, Krzysztof Grzyb, Kirsten Muri Boberg, Tom Hemming Karlsen, Martin Kummen, Johannes R. Hov   +12 more
wiley   +1 more source

Comparative analysis of the red-complex organisms and recently identified periodontal pathogens in the subgingival plaque of diabetic and nondiabetic patients with severe chronic periodontitis

Journal of Indian Society of Periodontology, 2023
Aim: This analytical case–control study sought to evaluate the presence of the recently established putative periodontal pathogen organisms, Filifactor alocis and Fretibacterium fastidiosum, against the levels of the already established red-complex ...
Divya Shree Pandian, Dhayanad John Victor, Priyanka Cholan, P SG Prakash, Sangeetha Subramanian, Sumi Priyadarshini Shankar   +5 more
doaj   +1 more source

A Hen in the Wolf Den: A Pathobiont Tale [PDF]

Immunity, 2018
Disruption of the gut microbiota is thought to contribute to disease onset in individuals with a genetic predisposition to autoimmunity. In a recent issue of Science, Manfredo Vieira et al. (2018) identify translocation of the gut commensal Enterococcus gallinarum into the liver as a trigger for the autoimmune disease systemic lupus erythematous.
Matteo M, Guerrini, Alexis, Vogelzang, Sidonia, Fagarasan   +2 more
openaire   +2 more sources

Histogram of the number of assigned pathobiont simulated reads.

, 2022
Histogram showing the read count frequency of true positive (blue) and false positive (red) pathobiont reads as identified by HAYSTAC and HOPS, after screening 200 spiked iterations of an ancient Oral Microbiome dataset sample (anc200e2repgn).
Evangelos A. Dimopoulos (4373215), Christina Warinner (513402), Alberto Carmagnini (13889699), Laurent A. F. Frantz (13889705), Evan K. Irving-Pease (4998092), Irina M. Velsko (13889702), Greger Larson (42564)   +6 more
core   +1 more source

Prevotella species as oral residents and infectious agents with potential impact on systemic conditions

Journal of Oral Microbiology, 2022
Oral Prevotella are known as anaerobic commensals on oral mucosae and in dental plaques from early life onwards, including pigmented P. melaninogenica, P. nigrescens, and P. pallens and non-pigmented Prevotella species. Many Prevotella species contribute
Eija Könönen, Dareen Fteita, Ulvi K. Gursoy, Mervi Gursoy   +3 more
doaj   +1 more source

Pathobionts of the gastrointestinal microbiota and inflammatory disease [PDF]

Current Opinion in Immunology, 2011
Our immune system is charged with the vital mission of identifying invading pathogens and mounting proper inflammatory responses. During the process of clearing infections, the immune system often causes considerable tissue damage. Conversely, if the target of immunity is a member of the resident microbiota, uncontrolled inflammation may lead to host ...
Chow, Janet, Tang, Haiqing, Mazmanian, Sarkis K.   +2 more
openaire   +3 more sources

Gastrointestinal Pathobionts in Pediatric Crohn’s Disease Patients [PDF]

International Journal of Microbiology, 2018
Crohn’s disease (CD) is an inflammatory disease of the gastrointestinal tract, with a rising incidence worldwide, particularly in children. CD is thought to arise due to an immune response to environmental factors. The role of bacteria in CD has recently been highlighted, and here, we examine the prevalence of two bacterial species ...
Rachel V. Purcell, Nadeem O. Kaakoush, Hazel M. Mitchell, John F. Pearson, Jacqueline I. Keenan   +4 more
openaire   +3 more sources