Results 101 to 110 of about 18,034 (241)

Molecular characterisation of the underlying mechanisms of pathogen-associated molecular pattern (PAMP) recognition in fish

, 2011
The innate immune response is based upon the activation of a restricted number of genotypic encoded receptors, the pathogen recognition receptors (PRRs). PRRs can be soluble proteins such as plasmatic PGRPs or cell membraneanchored TLRs able to recognize pathogens or their pathogen-associated molecular patterns (PAMPs).
openaire   +1 more source

Pathogen-associated molecular patterns (PAMPs) derived from Leishmania and bacteria increase gene expression of antimicrobial peptides and gut surface proteins in sand flies

International Journal for Parasitology
The interaction between pathogens and vectors' physiology can impact parasite transmission. Studying this interaction at the molecular level can help in developing control strategies. We study leishmaniases, diseases caused by Leishmania parasites transmitted by sand fly vectors, posing a significant global public health concern. Lipophosphoglycan (LPG)
Barbora, Vomáčková Kykalová, Fabiana, Sassù, Felipe, Dutra-Rêgo, Rodrigo Pedro, Soares, Petr, Volf, Erich, Loza Telleria   +5 more
openaire   +2 more sources

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, EarlyView.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

Aerobic Exercise Training Increases Circulating sRAGE in Adults With Type 2 Diabetes: Associations With Sheddase Regulation

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Objective Soluble receptor for advanced glycation end‐products (sRAGE) and soluble Toll‐like receptor 4 (sTLR4) are circulating pattern recognition receptor isoforms implicated in inflammatory regulation in type 2 diabetes mellitus (T2DM). This study examined the effects of supervised aerobic exercise training (AET) on circulating sRAGE, sTLR4,
Ryan K. Perkins, Corey E. Mazo, James Shadiow, Pallavi Varshney, Edwin R. Miranda, Victoria R. Miranda, Maggie Eisenberg, Jane E. Nakamura, Elif A. Oral, Jacob M. Haus   +9 more
wiley   +1 more source

High-fat diet induced changes in gut microbiota and pathogen associate molecular patterns (PAMPS) [PDF]

Proceedings of the Nutrition Society, 2014
L. M. Williams, C. Erridge, C. Grant, A. C. Morris, S. H. Duncan, R. J. Wallace, A. W. Walker, H. J. Flint   +7 more
openaire   +1 more source

Pronounced Reductions in Plasma Citrulline Indicate Severe Intestinal Mucosal Barrier Injury During Induction Therapy for Pediatric Acute Myeloid Leukemia

European Journal of Haematology, EarlyView.
ABSTRACT Objectives Pediatric acute myeloid leukemia (AML) chemotherapy regimens are frequently burdened by fever episodes, systemic inflammation and bloodstream infections (BSI). Mucosal barrier injury may contribute to these complications, but its role in childhood AML remains uninvestigated.
Carla Warley Kjær, Maria Ebbesen Sørum, Silvia De Pietri, Claus Moser, Malene Johanne Petersen, Marianne Hoffmann, Henrik Hasle, Sarah Weischendorff, Klaus Müller   +8 more
wiley   +1 more source

Regulation of ubiquitination in sepsis: from PAMP versus DAMP to peripheral inflammation and cell death

Frontiers in Immunology
Sepsis (sepsis) is a systemic inflammatory response triggered by infection, and its pathologic features include overproduction of peripheral inflammatory factors (e.g., IL-1β, IL-6, TNF-α), which ultimately leads to cytokine storm and multiple organ ...
Yueying Li, Jiongyan Yu, Zhiwen Zeng, Weixiong Lin   +3 more
doaj   +1 more source

Role of human RNase 7 in neuronal and glial cell models: moving towards an unexpected new functional link

The FEBS Journal, EarlyView.
Human RNase 7 is known to exert antimicrobial activity in epithelial tissues. Here, using SH‐SY5Y and U‐87 MG, neuroblastoma and glioblastoma cell lines, respectively, we found that RNase 7 enhances immune responses to LPS stimulation by reducing the expression of pro‐inflammatory cytokines, nitric oxide, and ROS.
Rosanna Culurciello, Maria Cristiano, Ilaria Di Nardo, Ida Palumbo, Erika Piccolo, Rosario Oliva, Andrea Bosso, Aldo Donizetti, Eugenio Notomista, Elio Pizzo   +9 more
wiley   +1 more source

MicroRNA-1985 enhances the redox capability of scallop (Patinopecten yessoensis) in response to poly(I:C) stimulation by targeting MNK1

Frontiers in Immunology
To clarify the microRNA (miRNA)-target gene axis is involved in response to pathogen-associated molecular pattern (PAMP)-induced oxidative stress in shellfish, the full-length cDNA of a novel mitogen-activated protein kinase-interacting kinase 1 (MNK1 ...
Linghui Yu, Linghui Yu, Huiqi Deng, Shaohua Liu, Jianpin Xia, Zhenlin Hao, Donghong Yin, Yaoyao Zhan, Yaqing Chang, Yaqing Chang   +9 more
doaj   +1 more source

ADAM17 and its proteolytic targets in disease pathogenesis

The FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source