Results 21 to 30 of about 17,963 (241)

A Broad-Spectrum Infection Diagnostic that Detects Pathogen-Associated Molecular Patterns (PAMPs) in Whole Blood [PDF]

EBioMedicine, 2016
Blood cultures, and molecular diagnostic tests that directly detect pathogen DNA in blood, fail to detect bloodstream infections in most infected patients. Thus, there is a need for a rapid test that can diagnose the presence of infection to triage patients, guide therapy, and decrease the incidence of sepsis.An Enzyme-Linked Lectin-Sorbent Assay ...
Cartwright, Mark, Rottman, Martin, Shapiro, Nathan I., Seiler, Benjamin, Lombardo, Patrick, Gamini, Nazita, Tomolonis, Julie, Watters, Alexander L., Waterhouse, Anna, Leslie, Dan, Bolgen, Dana, Graveline, Amanda, Kang, Joo H., Didar, Tohid, Dimitrakakis, Nikolaos, Cartwright, David, Super, Michael, Ingber, Donald E.   +17 more
openaire   +5 more sources

Development of a Pseudomonas syringae–Arabidopsis Suspension Cell Infection System for Investigating Host Metabolite-Dependent Regulation of Type III Secretion and Pattern-Triggered Immunity

Molecular Plant-Microbe Interactions, 2019
The importance of pattern-triggered immunity (PTI) in plant defense has been clearly established through genetic studies of mutants lacking functional pattern recognition receptors (PRRs) and signaling components downstream of PRR activation.
Qing Yan, Conner J. Rogan, Jeffrey C. Anderson   +2 more
doaj   +1 more source

Post-Translational Modification of HMGB1 Disulfide Bonds in Stimulating and Inhibiting Inflammation

Cells, 2021
High mobility group box 1 protein (HMGB1), a highly conserved nuclear DNA-binding protein, is a “damage-associated molecular pattern” molecule (DAMP) implicated in both stimulating and inhibiting innate immunity.
Ulf Andersson, Kevin J. Tracey, Huan Yang   +2 more
doaj   +1 more source

Suppression of hepatitis B virus through therapeutic activation of RIG-I and IRF3 signaling in hepatocytes

iScience, 2021
Summary: Hepatitis B virus (HBV) mediates persistent infection, chronic hepatitis, and liver disease. HBV covalently closed circular (ccc)DNA is central to viral persistence such that its elimination is considered the cornerstone for HBV cure ...
Sooyoung Lee, Ashish Goyal, Alan S. Perelson, Yuji Ishida, Takeshi Saito, Michael Gale, Jr.   +5 more
doaj   +1 more source

The Fungal Effector Avr-Pita Suppresses Innate Immunity by Increasing COX Activity in Rice Mitochondria

Rice, 2021
Background Avr-Pita was the first effector identified in the blast fungus (Magnaporthe oryzae)–rice (Oryza sativa) pathosystem. However, the molecular mechanism underlying its effects on the host plant has remained a long-standing mystery.
Jingluan Han, Xiaoyu Wang, Fengpin Wang, Zhe Zhao, Gousi Li, Xiaoyuan Zhu, Jing Su, Letian Chen   +7 more
doaj   +1 more source

Effects of low dose GM-CSF on microglial inflammatory profiles to diverse pathogen-associated molecular patterns (PAMPs) [PDF]

Journal of Neuroinflammation, 2007
It is well appreciated that obtaining sufficient numbers of primary microglia for in vitro experiments has always been a challenge for scientists studying the biological properties of these cells. Supplementing culture medium with granulocyte-macrophage colony-stimulating factor (GM-CSF) partially alleviates this problem by increasing microglial yield.
Esen, Nilufer, Kielian, Tammy
openaire   +4 more sources

A new proteinaceous pathogen‐associated molecular pattern (PAMP) identified in Ascomycete fungi induces cell death in Solanaceae [PDF]

New Phytologist, 2017
Summary Pathogen‐associated molecular patterns (PAMPs) are detected by plant pattern recognition receptors (PRRs), which gives rise to PAMP‐triggered immunity (PTI). We characterized a novel fungal PAMP, Cell Death Inducing 1 (RcCDI1), identified in the Rhynchosporium commune transcriptome sampled at an early stage of barley (Hordeum vulgare ...
Franco-Orozco, B., Berepiki, A., Ruiz, O., Gamble, L., Griffe, L. L., Wang, S., Birch, P. R. J., Kanyuka, K., Avrova, A.   +8 more
openaire   +3 more sources

Safety of Therapeutic Fever Induction in Cancer Patients Using Approved PAMP Drugs

Translational Oncology, 2018
William Coley, between 1895 and 1936, treated hundreds of cancer patients using infusions of fever inducing bacerial extracts. Similar experiments were done by Klyuyeva and co-workers in the 1940ies in Russia using trypanosoma extracts.
Uwe Rudolf Max Reuter, Ralf Oettmeier, Uwe Hobohm   +2 more
doaj   +1 more source

HvWRKY2 acts as an immunity suppressor and targets HvCEBiP to regulate powdery mildew resistance in barley

Crop Journal, 2023
Plants use a sophisticated immune system to perceive pathogen infection and activate immune responses in a tightly controlled manner. In barley, HvWRKY2 acts as a repressor in barley disease resistance to the powdery mildew fungus, Blumeria graminis f ...
Deshui Yu, Renchun Fan, Ling Zhang, Pengya Xue, Libing Liao, Meizhen Hu, Yanjun Cheng, Jine Li, Ting Qi, Shaojuan Jing, Qiuyun Wang, Arvind Bhatt, Qian-Hua Shen   +12 more
doaj   +1 more source

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source