Results 131 to 140 of about 1,638,877 (290)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Mechanisms underlying persistent liver fibrosis progression in Schistosoma-infected individuals post-treatment

Infectious Diseases of Poverty
Background Schistosomiasis, an infectious disease of poverty, remains a public health challenge worldwide. Although praziquantel chemotherapy has been proven to be an effective antiparasitic intervention, real-world evidence indicates that in patients ...
Zhigang Lei, Sha Zhou, Chuan Su, Guanling Wu   +3 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Genome-wide accumulations of non-random adaptive point mutations drive westward evolution of Helicobacter pylori

BMC Microbiology
Background For last seven decades we remained convinced that the natural point mutations occur randomly in the genome of an organism. However, our whole genome sequence analyses show that for the gastric pathogen Helicobacter pylori, which causes peptic ...
R. J. Retnakumar, Prakash Chettri, Sangey Chhophel Lamtha, K. C. Sivakumar, Priya Dutta, Pahil Sen, Sanjit Biswas, Nikita Agarwal, Angitha N. Nath, T. Barani Devi, Namrata Thapa, Jyoti Prakash Tamang, Santanu Chattopadhyay   +12 more
doaj   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Survival of Fecal Contamination Indicator Organisms in Soil [PDF]

, 1995
Soils amended with human or animal waste may result in pathogen contamination of ground and surface water. Because temperature has been shown to affect pathogen survival, two laboratory studies were conducted to evaluate the impact of extremes in ...
Teague, K. A., Vendrell, P. F., Wolf, D. C.   +2 more
core   +2 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Combined ϵ-Toxin Nanovaccine with Enhanced Immunity for Effective Protection in a Murine Model

International Journal of Nanomedicine
Dongxue Li,1– 3,* Li Tang,1,* Xinyu Fang,1,* Tingting Liu,1,* Xi Luo,1 Jiaxin Li,1 Jing Wang,1 Yanwei Li,1 Bing Yuan,1 Jinglin Wang,1 Shan Gao,1 Lin Kang,1 Baohua Zhao,2 Wenwen Xin1 1State Key Laboratory of Pathogen and ...
Li D, Tang L, Fang X, Liu T, Luo X, Li J, Wang J, Li Y, Yuan B, Wang J, Gao S, Kang L, Zhao B, Xin W   +13 more
doaj  

Loss of Gst1 enhances resistance to MMS by reprogramming the transcription of DNA damage response genes in a Rad53-dependent manner in Candida albicans

Cell Communication and Signaling
The DNA damage response is a highly conserved protective mechanism that enables cells to cope with various lesions in the genome. Extensive studies across different eukaryotic cells have identified the crucial roles played by components required for ...
Huaxin Cai, Yuting Feng, Jia Wang, Zhenyu Cao, Rui Lv, Jinrong Feng   +5 more
doaj   +1 more source