Results 61 to 70 of about 1,638,877 (290)

Pathogen disgust sensitivity: Individual differences in pathogen perception or pathogen avoidance?

Motivation and Emotion, 2021
The emotion disgust motivates the avoidance of pathogens and contaminants. Individuals differ in their tendency to experience disgust and this is reflected in pathogen disgust sensitivity. Yet, it remains unclear which differences in psychological processes are captured by pathogen disgust sensitivity. We tested two hypotheses about how the information
Florian van Leeuwen, Bastian Jaeger
openaire   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Activation of primary hepatic stellate cells and liver fibrosis induced by targeting TGF-β1/Smad signaling in schistosomiasis in mice

Parasites & Vectors, 2022
Background In mice, liver fibrosis is the most serious pathologic change during Schistosoma japonicum (S. japonicum) infection. Schistosomiasis is mainly characterized by schistosome egg-induced granulomatous fibrosis.
Ping Huang, Huihui Ma, Yun Cao, Tingzheng Zhan, Tingting Zhang, Xinyi Wang, Yanan Zhang, Jing Xu, Chaoming Xia   +8 more
doaj   +1 more source

Studying pathogens degrades BLAST-based pathogen identification

Scientific Reports, 2022
AbstractAs synthetic biology becomes increasingly capable and accessible, it is likewise increasingly critical to be able to make accurate biosecurity determinations regarding the pathogenicity or toxicity of particular nucleic acid or amino acid sequences.
Jacob Beal, Adam Clore, Jeff Manthey
openaire   +3 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Evaluation of factors influencing the guide to read biomedical English literature course for Chinese new medical postgraduates—a multiple regression analysis

BMC Medical Education, 2019
Background There is a dearth of published literature that demonstrates the impact of a Guide to Reading Biomedical English Literature course on new Chinese medical postgraduates.
Zhipeng Xu, Jingfan Qiu, Bingya Yang, Peng Huang, Lei Cai, Lin Chen, Min Hou, Minjun Ji, Guanling Wu   +8 more
doaj   +1 more source

Preparation of a Klebsiella pneumoniae conjugate nanovaccine using glycol-engineered Escherichia coli

Microbial Cell Factories, 2023
Background Engineered strains of Escherichia coli have been used to produce bioconjugate vaccines using Protein Glycan Coupling Technology (PGCT). Nanovaccines have also entered the vaccine development arena with advances in nanotechnology and have been ...
Yan Liu, Chao Pan, Kangfeng Wang, Yan Guo, YanGe Sun, Xiang Li, Peng Sun, Jun Wu, Hengliang Wang, Li Zhu   +9 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Accepting higher morbidity in exchange for sacrificing fewer animals in studies developing novel infection-control strategies. [PDF]

, 2020
Preventing bacterial infections from becoming the leading cause of death by the year 2050 requires the development of novel, infection-control strategies, building heavily on biomaterials science, including nanotechnology.
Busscher, Henk J., Frijlink, Hendrik W., Grainger, David W., Hinrichs, Wouter L.J., Jutte, Paul, Kates, Stephen, Liu, Jian, Liu, Jianfeng, Parvizi, Javad, Rotello, Vincent M., Schaer, Thomas P., Shi, Linqi, Shi, Rui, van der Mei, Henny C., van Kooten, Theo G., Williams, Dustin, Woudstra, Willem   +16 more
core   +2 more sources

Targeting Antibiotic Tolerance, Pathogen by Pathogen [PDF]

Cell, 2018
Antibiotic tolerance, the capacity of genetically susceptible bacteria to survive the lethal effects of antibiotic treatment, plays a critical and underappreciated role in the disease burden of bacterial infections. Here, we take a pathogen-by-pathogen approach to illustrate the clinical significance of antibiotic tolerance and discuss how the ...
Meylan, Sylvain, Andrews, Ian W., Collins, James J.   +2 more
openaire   +4 more sources