Emerging Pathogen Threats in Transfusion Medicine: Improving Safety and Confidence with Pathogen Reduction Technologies [PDF]
Pathogens, 2023 Emerging infectious disease threats are becoming more frequent due to various social, political, and geographical pressures, including increased human–animal contact, global trade, transportation, and changing climate conditions. Since blood products for
Marcia Cardoso +3 more
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Pathogen Reduction for Platelets—A Review of Recent Implementation Strategies [PDF]
Pathogens, 2022 The development of pathogen reduction technologies (PRT) for labile blood components is a long-pursued goal in transfusion medicine. While PRT for red blood cells and whole blood are still in an early phase of development, different PRT platforms for ...
Paolo Rebulla, Daniele Prati
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The 4-Year Experience with Implementation and Routine Use of Pathogen Reduction in a Brazilian Hospital [PDF]
Pathogens, 2021 (1) Background: We reviewed the logistics of the implementation of pathogen reduction (PR) using the INTERCEPT Blood System™ for platelets and the experience with routine use and clinical outcomes in the patient population at the Sírio-Libanês Hospital ...
Roberta Maria Fachini +6 more
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Pathogen Reduction of Transfused Blood Components—The End of the Beginning Rather than the Beginning of the End [PDF]
PathogensTherapeutics derived from donated blood or its constituents are classifiable into blood components and plasma derivatives. The latter are defined as medicines/drugs/pharmaceuticals produced from the industrial fractionation of thousands of pooled plasma ...
Albert Farrugia +3 more
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INTERCEPT Pathogen Reduction in Platelet Concentrates, in Contrast to Gamma Irradiation, Induces the Formation of trans-Arachidonic Acids and Affects Eicosanoid Release during Storage [PDF]
Biomolecules, 2022 Pathogen inactivation techniques for blood products have been implemented to optimize clinically safe blood components supply. The INTERCEPT system uses amotosalen together with ultraviolet light wavelength A (UVA) irradiation.
Gerda C. Leitner +11 more
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Extra benefit of microalgae in raw piggery wastewater treatment: pathogen reduction [PDF]
Microbiome, 2022 Background Monitoring microbial communities especially focused on pathogens in newly developed wastewater treatment systems is recommended for public health. Thus, we investigated the microbial community shift in a pilot-scale microalgal treatment system
Sang-Ah Lee +3 more
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A systematic review and meta-analysis of pathogen reduction in onsite sanitation systems [PDF]
Water Research X, 2023 The safe management of fecal sludge from the 3.4 billion people worldwide that use onsite sanitation systems can greatly reduce the global infectious disease burden.
Isaac G. Musaazi +6 more
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Platelet Pathogen Reduction Technologies Alter the MicroRNA Profile of Platelet-Derived Microparticles [PDF]
Frontiers in Cardiovascular Medicine, 2020 Despite improvements in donor screening and increasing efforts to avoid contamination and the spread of pathogens in clinical platelet concentrates (PCs), the risks of transfusion-transmitted infections remain important.
Idrissa Diallo +10 more
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Pathogen reduction technologies: The pros and cons for platelet transfusion
Platelets, 2018 The transfusion of platelets is essential for diverse pathological conditions associated with thrombocytopenia or platelet disorders. To maintain optimal platelet quality and functions, platelets are stored as platelet concentrates (PCs) at room ...
Audrey Magron +3 more
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The impact of pathogen reduction on ABO isoagglutinin titers in apheresis platelets [PDF]
Hematology, Transfusion and Cell TherapyBackground: Platelet transfusions are a cornerstone of modern medical care, used across various clinical contexts. Ensuring the compatibility of blood products, especially regarding ABO isoagglutinins, is critical to minimize adverse reactions.
Mikayel Yeghiazaryan +5 more
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