Results 111 to 120 of about 1,694,622 (312)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Acne pathogenesis and treatment

, 2021
Acne is a condition characterized by chronic inflammation of the pilosebaceous unit. The inflammation can be caused by abnormal keratinization which blocks the pore, excess sebum production, and the presence of Cutibacterium acnes (C. acnes).
Shakeel, Areebah
core  

A Chimeric Peptide Derived from a Bacterial Effector Protein Attenuates TLR-2/4-Mediated Production of Pro-Inflammatory Cytokines and Enhances the Cellular Availability of Gentamicin

Journal of Inflammation Research
Binita Roy Nandi,1,2 Biswaranjan Patra,1,2 Girish K Radhakrishnan1 1Laboratory of Bacterial Pathogenesis, National Institute of Animal Biotechnology, Hyderabad, Telangana, 500032, India; 2Regional Centre for Biotechnology (RCB), Faridabad, 121001 ...
Nandi BR, Patra B, Radhakrishnan GK
doaj  

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

Pathogenesis of oral FIV infection

, 2017
Feline Immunodeficiency Virus; FIV Pathogenesis; Saliva; oral; transmission; Oral Transmission; HIV; HIV-Induced Oral Disease; HIV pathogenesis.Feline immunodeficiency virus (FIV) is the feline analogue of human immunodeficiency virus (HIV) and features ...
Miller, Craig A.
core   +1 more source

High‐Resolution MRI Revealed Different Etiology‐Specific Associations With Cerebral Infarction in Adult Moyamoya Vasculopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han, Jiachun Pan, Yuehui Hong, Xiaoyuan Fan, Ming Yao, Lixin Zhou, Yicheng Zhu, Feng Feng, Jun Ni   +8 more
wiley   +1 more source

Secreted biomolecules in fungal plant pathogenesis

, 2015
Fungal‐plant interactions are complex. Most exist for just a few brief days, while some continue over many months. During each interaction, a staggering repertoire of secreted biomolecules are produced by each fungal species to gain nutrients and to ...
Kim E. Hammond-Kosack, Brown, N. A., Hammond-Kosack, K. E., Neil Andrew Brown   +3 more
core   +1 more source

Long-term efficacy of an inactivated H5N1 whole-particle influenza vaccine in nonhuman primates

npj Vaccines
Outbreaks of H5 highly pathogenic avian influenza A viruses (HPAIVs) in animals pose a threat to humans immunologically naïve to avian influenza viruses.
Misako Nakayama, Naoko Kitagawa, Cong Thanh Nguyen, Takako Sasamura, Kyoko Takashima, Hirohito Ishigaki, Hideaki Ishida, Saori Suzuki, Yoshihiro Sakoda, Mai Quynh Le, Hiroshi Kida, Kazumasa Ogasawara, Yasushi Itoh   +12 more
doaj   +1 more source

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

Outbreak of Zika virus pathogenesis and quest of its vaccine development: Where do we stand now? [PDF]

, 2018
Zika virus (ZIKV) infection is a life-threatening tropical infection, mainly caused by mosquito bite. After a very long period of quietness, ZIKV infections have become a problematic issue again.
SANCHEZ APARICIO, PEDRO; 168298, Aarti, Chirom;x1242471, SANCHEZ APARICIO, PEDRO, Aarti, Chirom, KHUSRO, AMEER;x1237404, BARBABOSA PLIEGO, ALBERTO; 348264, BARBABOSA PLIEGO, ALBERTO, KHUSRO, AMEER   +7 more
core   +1 more source