Results 121 to 130 of about 2,392,377 (310)

JAG1 overexpression contributes to Notch1 signaling and the migration of HTLV-1-transformed ATL cells

open access: yesJournal of Hematology & Oncology, 2018
Background HTLV-1 is a retrovirus that infects over 20 million people worldwide and is responsible for the hematopoietic malignancy adult T cell leukemia (ATL). We previously demonstrated that Notch is constitutively activated in ATL cells.
Marcia Bellon   +4 more
doaj   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang   +10 more
wiley   +1 more source

A Chimeric Peptide Derived from a Bacterial Effector Protein Attenuates TLR-2/4-Mediated Production of Pro-Inflammatory Cytokines and Enhances the Cellular Availability of Gentamicin

open access: yesJournal of Inflammation Research
Binita Roy Nandi,1,2 Biswaranjan Patra,1,2 Girish K Radhakrishnan1 1Laboratory of Bacterial Pathogenesis, National Institute of Animal Biotechnology, Hyderabad, Telangana, 500032, India; 2Regional Centre for Biotechnology (RCB), Faridabad, 121001 ...
Nandi BR, Patra B, Radhakrishnan GK
doaj  

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang   +6 more
wiley   +1 more source

Long-term efficacy of an inactivated H5N1 whole-particle influenza vaccine in nonhuman primates

open access: yesnpj Vaccines
Outbreaks of H5 highly pathogenic avian influenza A viruses (HPAIVs) in animals pose a threat to humans immunologically naïve to avian influenza viruses.
Misako Nakayama   +12 more
doaj   +1 more source

Combination antiretroviral therapy -associated lipodystrophy : insights into pathogenesis and treatment [PDF]

open access: yes, 2011
Introduction: Combination antiretroviral therapy (cART) has decreased morbidity and mortality of individuals infected with human immunodeficiency virus type 1 (HIV-1). Its use, however, is associated with adverse effects which increase the patients risk
Sevastianova, Ksenia
core  

A 73‐Year‐Old Man With Several Years of Difficulty Climbing Stairs and Frequent Tripping

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 73‐year‐old man presented with progressive weakness and atrophy predominantly affecting the distal finger flexors and quadriceps muscles. Electrophysiological studies demonstrated mixed myogenic and neurogenic features. Muscle MRI showed inflammatory changes, and muscle biopsy revealed granulomatous myositis with histologic features ...
Mehmet Can Sari   +3 more
wiley   +1 more source

Neuron impairment or loss in brain may be responsible for type 2 diabetes and essential hypertension [PDF]

open access: yes, 2010
Type 2 diabetes and essential hypertension are both very common chronic diseases. Type 2 diabetes is often associated with hypertension, but the exact causes of them are unknown.
Xiang Zheng, Xue Zhou
core   +1 more source

Air Pollution and the Risk and Progression of Multiple Sclerosis: A Systematic Review and Meta‐Analysis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose Air pollution has been linked to several neurological conditions, including stroke and neurodegenerative diseases. Evidence regarding its association with multiple sclerosis (MS) remains conflicting, limited by small sample sizes. Methods PubMed, Embase, Scopus, and Cochrane controlled register of trials (CENTRAL) were searched on ...
Ahmad A. Toubasi, Thuraya N. Al‐Sayegh
wiley   +1 more source

Research Progress on Antivirulence Agents Targeting the Accessory Gene Regulator (Agr) System of Staphylococcus Aureus

open access: yesInfection and Drug Resistance
Lingwei Chen,1,2 Mintao Huang,1,2 Ying Chen,1,2 Yanzhen Lin,1,2 Yanguang Cong1– 4 1Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong
Chen L, Huang M, Chen Y, Lin Y, Cong Y
doaj  

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