Results 151 to 160 of about 256,194 (269)

The prevalence of protein misfolding as a mechanism for hereditary deafness. [PDF]

PLoS Genet
Gogal RA, Cox GM, Kolbe DL, Odell AM, Ovel CE, McCormick KI, Hong B, Azaiez H, Casavant TL, Smith RJH, Braun TA, Schnieders MJ.   +11 more
europepmc   +1 more source

Prostate Cancer Patient‐Derived Organoids (PDOs) as Functional Avatars for Antisense Oligonucleotide (ASO)‐Based Personalized Therapy

Advanced Healthcare Materials, EarlyView.
Prostate patient‐derived organoids (PDOs) were established from TURP and biopsy specimens with >90% success and retain key features of their tissues of origin, making them functional avatars for antisense oligonucleotide (ASO) therapy . Transfecting single cells outside the Matrigel matrix and then reconstituting organoids overcomes the 3D delivery ...
Thi Thom Tran, Thi Tu Uyen Phan, Michael Baboudjian, Quang Hieu Duong, Ines Sousa, Thi Thuy Le, Virginie Baylot, Sophie Giusiano, Laurent Daniel, Pauline Brige, Benjamin Guillet, Cyrille Bastide, Carmen Garrido, David Taïeb, Thi Khanh Le, Palma Rocchi   +15 more
wiley   +1 more source

The Animal Variant Classification Guidelines v2: An Update With New Criteria and Improved Clarifications. [PDF]

Anim Genet
Desmet L, Ferrari C, Abitbol M, Anderson H, Bannasch D, Bauer H, Bell J, Bilgen N, Chevallier L, Dufaure de Citres C, Donner J, Finno CJ, Giovambattista G, Harrison SM, Hayward JJ, Häggström J, Huff JT, Leeb T, Ljungvall I, Longeri M, Lyons LA, Martinez M, Mellersh C, Nicholas FW, Ohlsson Å, Petersen JL, Smets P, Strillacci MG, Tammen I, Van Buren S, van Steenbeek FG, Broeckx BJG.   +31 more
europepmc   +1 more source

Phase Engineering of Nanomaterials (PEN): Evolution, Current Challenges, and Future Opportunities

Advanced Materials, EarlyView.
This review summarizes the synthesis, phase transition, advanced characterization spanning ex situ to in situ and operando techniques, and diverse applications of phase engineering of nanomaterials (PEN). It further outlines key challenges and future opportunities, such as phase stability, architecture control, and artificial intelligence (AI)‐driven ...
Ye Chen, Zhanxi Fan, Jingjie Ge, Qiyuan He, Zhuangchai Lai, Jiawei Liu, Chaoliang Tan, Hua Zhang   +7 more
wiley   +1 more source

Why are archaea not pathogenic? A hypothesis based on metabolism-habitat covariation. [PDF]

mBio
Harrison DJ, Fullmer MS, Takeuchi N.
europepmc   +1 more source

GaSex Nanoparticles Modulate Neutrophil Function and Mitigate NET‐Driven Osteogenic Impairment in Osteomyelitis Therapy

Advanced Materials, EarlyView.
Neutrophil extracellular traps (NETs) emerge as a critical repair‐limiting factor in osteomyelitis, driving osteoblast mitochondrial dysfunction and excessive PINK1/Parkin‐mediated mitophagy. Gallium–selenium nanoparticles (GaSex) scavenge reactive oxygen species, redirect neutrophils from NETosis toward bactericidal phagocytosis, eliminate methicillin‐
Kai Ye, Xuanzhe Liu, Zifan Pei, Chenyi Jiang, Xiaofen Zhang, Lin Lin, Qihang Fang, Binyu Chen, Longxiang Shen, Liang Cheng, Peng Ding, Xianyou Zheng   +11 more
wiley   +1 more source

Isolation, identification, and pathogenicity of Novel Duck Reovirus strain from ducklings in China. [PDF]

Poult Sci
Wang Z, Tan J, Xi H, Hu Y, Lei X, Tan M, Wei J, Lin C, Zhang F, Zeng Y, Wu C, Li N, Huang J, Li H.   +13 more
europepmc   +1 more source

Microfluidic Droplet Plate Preserving Single Human Induced Pluripotent Stem Cell‐Derived Cardiomyocytes Morphology and Function

Advanced Materials Technologies, EarlyView.
We introduce a novel method combining microfluidics, optogenetics, and human induced pluripotent stem cell (iPSC) technology to encapsulate single iPSC‐derived cardiomyocytes (iPSC‐CMs) in an optimal environment for functional characterization. This method enables direct genotype‐phenotype correlation for genetic studies and high‐throughput screening ...
Xiao‐Ting Wang, Rachel P. White, Yashasvi Tharani, Michael A. Finocchiaro, Leona M. Ripple, Maksymilian Prondzynski, Tania Konry, Vassilios J. Bezzerides   +7 more
wiley   +1 more source

Lipid-sensing GPR183-KRAS signaling mediates T_H17 autoimmunity and identifies fluvoxamine repurposing in uveitis. [PDF]

Sci Adv
Zhang C, Liu X, Xu N, Chen H, Gao Y, Gu C, Shen X, Wu J, Lu X, Zhang P, He Y, Xu Z, Su W.   +12 more
europepmc   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source