Results 171 to 180 of about 256,194 (269)

Mutations That Matter: Domain-Specific Mutational Hotspots in <i>BRCA1</i> and Its Key Interactors Differ Between TCGA and BCGA Breast Cancer Cohort-An In Silico Analysis. [PDF]

Cancers (Basel)
Kulkarni M, Neeraje KM, Das R, Laha S.
europepmc   +1 more source

Phosphorylated STYK1 Promotes Gemcitabine Resistance via Autophagy‐Mediated Cancer Stemness in Pancreatic Cancer

Advanced Science, EarlyView.
Gemcitabine resistance remains a major challenge in pancreatic ductal adenocarcinoma. This study identifies STYK1 as a key mediator of chemoresistance through autophagy‐dependent maintenance of cancer stemness. Gemcitabine‐activated AMPK phosphorylates STYK1 at Ser91 and Ser304, enhancing autophagy and stemness.
Xueying Dong, Shi Li, Chensong Huang, Xuehong Qian, Jieyu Guo, Yahao Guo, Guifang Wu, Qi Zhang, Hongfei Tan, Yu Han, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Chaojun Yan, Wenying Qin, Changchun Li, Xing‐Zhen Chen, Ying Zhao, Cefan Zhou, Jingfeng Tang   +20 more
wiley   +1 more source

H3 Subtype Avian Influenza Virus: Ecology, Cross-Species Evolution, and Public Health Threats. [PDF]

Microorganisms
Cheng K, Yu Z.
europepmc   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

SIMLINK enables accurate variant pathogenicity prediction through modeling the gene-variant-feature association structure. [PDF]

Bioinformatics
Li HD, Wang C, Yan D, Huang W, Li Z, Wang S.   +5 more
europepmc   +1 more source

Pathogenic Staphylococci [PDF]

BMJ, 1937
openaire   +2 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Isolation, Pathogenicity, and Genomic Analysis of a Virulent <i>Aeromonas salmonicida</i> ST2 Strain from <i>Thymallus arcticus grubei</i>. [PDF]

Biology (Basel)
Zhao R, Wang D, Wang J, Zhu J, Zhang Y, Ma K, Li S.   +6 more
europepmc   +1 more source

Motorizing pathogens

Seminars in Cell & Developmental Biology, 2015
Baum, J, Frischknecht, F
openaire   +3 more sources