Results 201 to 210 of about 402,308 (248)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Total Nephron Number: A Novel Predictor of Disease Progression in IgA Nephropathy. [PDF]

Kidney360
Miyasato Y, Yokoi H.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Neoadjuvant lenvatinib plus pembrolizumab in Merkel cell carcinoma: an investigator-initiated, open-label phase II trial. [PDF]

J Immunother Cancer
Brohl AS, Sondak VK, Wuthrick EJ, Kim Y, Eroglu Z, Markowitz J, Tarhini AA, Fan W, Martin J, Sneed L, Perez MC, Sarnaik A, Harrington M, Neves RI, Gonzalez RJ, Cruse CW, Zager JS, Tsai KY, Khushalani NI.   +18 more
europepmc   +1 more source

Epidemiology of pathologic myopia in UK adults with high myopia. [PDF]

Br J Ophthalmol
Yii F, Strang N, Bernabeu MO, Dhillon B, MacGillivray T, MacCormick IJC.   +5 more
europepmc   +1 more source

Surgical and survival outcomes of neoadjuvant IMRT-based chemoradiotherapy versus upfront surgery in borderline resectable pancreatic cancer: a retrospective cohort study. [PDF]

Front Oncol
Huang X, Yang H, Cai W.
europepmc   +1 more source

Epilepsy and Alzheimer Disease: Epidemiologic, Clinical, Molecular, and Neuropathologic Convergences and Divergences. [PDF]

Neurol Clin Pract
Devinsky O, Leitner DF, Kamondi A, Wisniewski T.   +3 more
europepmc   +1 more source

Spinal infection caused by <i>Aspergillus terreus</i> in immunocompetent individuals: a case report and literature review. [PDF]

Front Med (Lausanne)
Liu L, Pei M, Ma Y, Guo X, Guo S, Sun H, Zheng J, Su X, Meng L, Zhang X.   +9 more
europepmc   +1 more source

Neoadjuvant immunochemotherapy vs. neoadjuvant targeted therapy plus chemotherapy for EGFR-mutated non-small cell lung cancer: a retrospective study. [PDF]

BMC Cancer
Li F, Zhang C, Huang L, Wang Z, Ye G, Gu Z, Qi Y.   +6 more
europepmc   +1 more source