Results 81 to 90 of about 1,553,588 (294)

Physiological and pathological high frequency oscillations in focal epilepsy [PDF]

, 2018
Jan Cimbálník, Benjamin H. Brinkmann, Václav Křemen, Pavel Jurák, Brent Berry, Jamie J. Van Gompel, Matt Stead, Gregory A. Worrell   +7 more
openalex   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Primary diffuse large B-cell lymphoma of the mandible

Autopsy and Case Reports, 2019
Primary intraosseous non-Hodgkin lymphoma in the mandible is uncommon, representing about 0.6% of all extranodal lymphomas. We present the case of a 51-year-old male with a 4-month complaint of mandibular swelling and paresthesia, which had been ...
Juliana Mota Siqueira, Patrícia Maria Fernandes, Andrea Cruz Ferraz de Oliveira, José Vassallo, Fábio de Abreu Alves, Graziella Chagas Jaguar   +5 more
doaj   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Cutaneous metastases from colonic adenocarcinoma: case report Metástase cutânea de adenocarcinoma de cólon: relato de caso

Journal of Coloproctology, 2012
The presence of cutaneous metastases (CM) from a digestive tract cancer is infrequent, appearing in less than 5% of the cases. Given the low incidence of metastasis from colon adenocarcinoma, an unusual case that occurred in the Colorectal Surgery ...
Caroline Merci Caliari de Neves Gomes, Fang Chia Bin, Wilmar Artur Klug, Tiago Valois, Marilia Tassinari Gonçalves Preza   +4 more
doaj  

Reconstrução cirúrgica da estenose cicatricial de vias biliares pós-colecistectomia

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: Avaliar uma série de casos de estenose cicatricial de vias biliares pós-colecistectomia submetidos à reconstrução cirúrgica. MÉTODOS: Foi realizado estudo retrospectivo de 27 pacientes submetidos à reconstrução cirúrgica da via biliar por ...
Aderivaldo Coelho de Andrade
doaj   +1 more source

Effects of Subcutaneous Ochratoxin-A Exposure on Immune System of Broiler Chicks

Toxins, 2019
Ochratoxin A (OTA), an immunosuppressive mycotoxin, can increase the risk of many infectious diseases and contribute to economic losses to the poultry industry.
Shahzad Akbar Khan, Emerson J. Venancio, Mario A. Ono, Eduardo V. Fernandes, Elisa Y. Hirooka, Cleverson F. Shimizu, Alexandre Oba, Karina K. M. C. Flaiban, Eiko N. Itano   +8 more
doaj   +1 more source

Clinical, pathological and molecular predictors of Fulvestrant long-term benefit in Hormone Receptor-positive / HER2 negative advanced breast cancer [PDF]

, 2022
Rosalba Torrisi, Valentina Vaira, Laura Giordano, Annarita Destro, Vera Basilico, Saveria Mazzara, Piermario Salvini, Gabriella Gaudioso, Bethania Fernandes, Noemi Rudini, Giovanna Masci, Armando Santoro   +11 more
openalex   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source