Pathologic myopia (PM) is a major cause of irreversible visual impairment worldwide and especially in East Asian countries. The complications of PM include myopic maculopathy, myopic macular retinoschisis, dome-shaped macula, and myopic optic neuropathy.
Kyoko Ohno-Matsui+5 more
openaire +2 more sources
Eye shape and retinal shape, and their relation to peripheral refraction [PDF]
Purpose: We provide an account of the relationships between eye shape, retinal shape and peripheral refraction. Recent findings: We discuss how eye and retinal shapes may be described as conicoids, and we describe an axis and section reference system for
Atchison, David+4 more
core +2 more sources
Myopia and associated pathological complications [PDF]
AbstractBesides the direct economic and social burden of myopia, associated ocular complications may lead to substantial visual loss. In several population and clinic‐based cohorts, case–control and cross‐sectional studies, higher risks of posterior subcapsular cataract, cortical and nuclear cataract in myopic patients were reported. Patients with high
Edwin Chan Shih-Yen+3 more
openaire +3 more sources
Comparison of form-deprived myopia and lens-induced myopia in guinea pigs [PDF]
AIM: To study the efficacy difference between form-deprived myopia (FDM) and lens-induced myopia (LIM), the degree of myopia, axial length and pathological changes of the posterior sclera from guinea pigs were evaluated.METHODS: Four-week pigmented ...
Hui Xiao+3 more
core +1 more source
Peripapillary Detachment in Pathologic Myopia [PDF]
To describe peripapillary detachment in pathologic myopia (PDPM), a newly recognized fundus lesion.Retrospective medical record review.We evaluated a series of myopic eyes that had a yellow-orange elevation of the retina and retinal pigment epithelium at the inferior border of the myopic conus.Twenty eyes of 15 patients were identified during a 17-year
Gregg T. Kokame+6 more
openaire +3 more sources
Genome-wide analysis points to roles for extracellular matrix remodeling, the visual cycle, and neuronal development in myopia [PDF]
Myopia, or nearsightedness, is the most common eye disorder, resulting primarily from excess elongation of the eye. The etiology of myopia, although known to be complex, is poorly understood. Here we report the largest ever genome-wide association study (
Do, Chuong B.+6 more
core +5 more sources
Human PrimPol mutation associated with high myopia has a DNA replication defect [PDF]
PrimPol is a primase-polymerase found in humans, and other eukaryotes, involved in bypassing lesions encountered during DNA replication. PrimPol employs both translesion synthesis and repriming mechanisms to facilitate lesion bypass by the replisome ...
Aguilera+27 more
core +1 more source
Detection of pathological myopia by PAMELA with texture-based features through an SVM approach [PDF]
10.1260/2040-2295.1.1.1Journal of Healthcare Engineering111 ...
A. Fitzgibbon+15 more
core +3 more sources
Advances of optical coherence tomography in myopia and pathologic myopia [PDF]
The natural course of high-axial myopia is variable and the development of pathologic myopia is not fully understood. Advancements in optical coherence tomography (OCT) technology have revealed peculiar intraocular structures in highly myopic eyes and unprecedented pathologies that cause visual impairment. New OCT findings include posterior precortical
Shaheeda Mohamed+7 more
openaire +3 more sources
Automatic Diagnosis of Pathological Myopia from Heterogeneous Biomedical Data [PDF]
10.1371/journal.pone.0065736PLoS ...
A Iwase+30 more
core +2 more sources