Results 101 to 110 of about 1,686,445 (282)

Stain normalization in digital pathology: Clinical multi-center evaluation of image quality. [PDF]

J Pathol Inform, 2022
Michielli N, Caputo A, Scotto M, Mogetta A, Pennisi OAM, Molinari F, Balmativola D, Bosco M, Gambella A, Metovic J, Tota D, Carpenito L, Gasparri P, Salvi M.   +13 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Retrospective of Clinical Pathology of Herd Pigs in Extensive and Intensive Breeding

Scientific Papers Animal Science and Biotechnologies
The main characteristic of the herd of pigs in extensive and intensive breeding is the presence of breeding diseases of different aetiology. The research aimed to monitor the frequency of breeding diseases and organize the implementation of prophylactic ...
Jovan Bojkovski, Ivan Pavlović, Sreten Nedić, Radiša Prodanović, Sveta Arsić, Aleksandra Mitrović, Branislav Kureljušić, Nemanja Zdravković, Ana Vasić, Branko Angjelovski, Jasna Prodanov -Radulović   +10 more
doaj  

Machine learning for systems pathology

, 2014
Systems pathology attempts to introduce more holistic approaches towards pathology and attempts to integrate clinicopathological information with “-omics” technology.
Verleyen, Wim
core  

Cyclooxygenase-1 and -2 in the different stages of Alzheimer's disease pathology

, 2008
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the deposition of beta amyloid (Abeta) protein and the formation of neurofibrillary tangles. In addition, there is an increase of inflammatory proteins in the brains of AD patients.
Eikelenboom, P., Veerhuis, R, Hoozemans, J. J. M., van Haastert, E. S., Veerhuis, R., Rozemuller, J M, van Haastert, E S, Rozemuller, J. M., Hoozemans, J J M, Eikelenboom, P   +9 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Implementation of a required 3rd-year medical student surgical pathology clinical experience. [PDF]

Acad Pathol, 2022
Wegman SJ, Tretter JG, Zynger DL.
europepmc   +1 more source

PathBeat. Number 14 (Winter 2013) University of Iowa Department of Pathology.

, 2013
University of Iowa Department of Pathology ...

core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source