Results 111 to 120 of about 7,324,524 (245)

SPRAYDYE: a phase I/II randomised pilot study to assess the safety and feasibility of topically applied AKRO-6qcICG, a cathepsin-activatable fluorescent imaging agent, for real-time intraoperative resection margin assessment in breast-conserving surgery

Frontiers in Surgery
IntroductionThe incidence of tumour-positive surgical resection margins (TPRMs) after breast-conserving surgery (BCS) remains high, ranging from 10 to 40%.
Cedric M. W. Pesch, Cedric M. W. Pesch, Daan G. J. Linders, Taryn L. March, Martin Pool, A. Rob P. M. Valentijn, Denise E. Hilling, Denise E. Hilling, Ethan Walker, Brian Straight, Sven Mieog, Gerrit-Jan Liefers, Danielle Cohen, Hans Marten Hazelbag, Marieke E. Straver, James P. Basilion, James P. Basilion, James P. Basilion, Robert Rissmann, Robert Rissmann, Jacobus Burggraaf, Jacobus Burggraaf, Jacobus Burggraaf, Alexander L. Vahrmeijer   +23 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

PARÂMETROS BIOQUÍMICOS DE AVALIAÇÃO DA FUNÇÃO RENAL E HEPÁTICA DE EQUINOS COM CÓLICA SUBMETIDOS A LAPAROTOMIA, SOBREVIVENTES OU NÃO

Ciência Animal Brasileira, 2012
We examined 46 adult horses - six healthy, as control, (group 1) and 40 horses with colic submitted to treatment by laparotomy. Twenty animals had no postoperative complication (group 2), and twenty died or were euthanized from seven to ten days after ...
Paula Alessandra Di Filippo, Andressa Francisca da Silva Nogueira, Aracélle Elisane Alves, Aureo Evangelista Santana   +3 more
doaj  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Electronic chemical pathology consultation service and dried blood spot metabolic screening in hospital patients

, 2012
AIM: Inborn errors of metabolism (IEM) are an unpopular and difficult subject and most clinicians are unfamiliar with them. Although chemical pathologists have a long-standing practice in advising test strategy and result interpretation especially from ...
Lee, HHC, Au, CK, Wong, CK, Chen, SPL, Sham, CO, Chan, AYW, Mak, CM, Tse, K, Law, CY, Siu, WK, Poon, WT, Lam, CW, Kwong, NS, Lee, HK, Yeung, S, Ching, CK   +15 more
core   +1 more source

Retrospective of Clinical Pathology of Herd Pigs in Extensive and Intensive Breeding

Scientific Papers Animal Science and Biotechnologies
The main characteristic of the herd of pigs in extensive and intensive breeding is the presence of breeding diseases of different aetiology. The research aimed to monitor the frequency of breeding diseases and organize the implementation of prophylactic ...
Jovan Bojkovski, Ivan Pavlović, Sreten Nedić, Radiša Prodanović, Sveta Arsić, Aleksandra Mitrović, Branislav Kureljušić, Nemanja Zdravković, Ana Vasić, Branko Angjelovski, Jasna Prodanov -Radulović   +10 more
doaj  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

An Analysis of the Correlation Between Clinical Indexes and Pathological Classifications in 202 Patients with Lupus Nephritis

Journal of Inflammation Research, 2021
Bang-Pin Pan,1,* Zhi-Jian Feng,2,* Xiao-Lan Li,1 Li-Ping He,3 Dong Jiang,1 Rui-Xian Zhang,1 Wen-Ting Cao,1 Mei Cai,1 Yun-Feng Bi,1 Wen-Fang Wang,1 Chun-Yan Luan1 1Department of Dermatology, The Second Affiliated Hospital of Kunming Medical ...
Pan BP, Feng ZJ, Li XL, He LP, Jiang D, Zhang RX, Cao WT, Cai M, Bi YF, Wang WF, Luan CY   +10 more
doaj  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source