Results 131 to 140 of about 7,324,524 (245)

CYP3A4 and CYP3A5 Genotyping Recommendations: A Joint Consensus Recommendation of the Association for Molecular Pathology, Clinical Pharmacogenetics Implementation Consortium, College of American Pathologists, Dutch Pharmacogenetics Working Group of the Royal Dutch Pharmacists Association, European Society for Pharmacogenomics and Personalized Therapy, and Pharmacogenomics Knowledgebase. [PDF]

J Mol Diagn, 2023
Pratt VM, Cavallari LH, Fulmer ML, Gaedigk A, Hachad H, Ji Y, Kalman LV, Ly RC, Moyer AM, Scott SA, van Schaik RHN, Whirl-Carrillo M, Weck KE.   +12 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Clinical and Pathological Characteristics of Patients with Non-Small Cell Lung Cancer: Retrospective Study

Al-Azhar International Medical Journal
Background: The number of fatalities caused by lung cancer has surpassed that of prostate, breast, brain, and colorectal cancers all together. As of recently, it ranked second among female cancer killers and first among male cancer patients overall.
Ahmed El Agamawi, Mohamed Tarrad, Mahmoud Ghanem   +2 more
doaj   +1 more source

COVID-19 and Speech-Language Pathology Clinical Practice of Voice and Upper Airway Disorders. [PDF]

Am J Speech Lang Pathol, 2021
Doll EJ, Braden MN, Thibeault SL.
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Sudden Death from Ischemic Heart Disease While Driving: Cardiac Pathology, Clinical Characteristics, and Countermeasures. [PDF]

Med Sci Monit, 2021
Miao Q, Zhang YL, Miao QF, Yang XA, Zhang F, Yu YG, Li DR.   +6 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Swiss digital pathology recommendations: results from a Delphi process conducted by the Swiss Digital Pathology Consortium of the Swiss Society of Pathology.

Integration of digital pathology (DP) into clinical diagnostic workflows is increasingly receiving attention as new hardware and software become available.
Cathomas, Gieri Risch, Kölzer, Viktor, Zlobec, Inti, Kupferschmid, Joel, Henkel, Maurice, Soldini, Davide, Berezowska, Sabina Anna, Huschauer, Viola, Merkler, Doron, Kreutzfeldt, Mario, Grobholz, Rainer, Janowczyk, Andrew, Tinguely, Marianne, Gasic, Radivoje, Rau, Tilman, Eyberg, Isgard, Mertz, Kirsten D, Walker, Cedric, Rössle, Matthias, Jochum, Wolfram, Mazzucchelli, Luca, Mallet, Thomas   +21 more
core   +1 more source

Usefulness of cerebrospinal fluid analysis in dogs and cats with suspected intracranial disease and normal magnetic resonance imaging

Frontiers in Veterinary Science
Cerebrospinal fluid (CSF) analysis is a common diagnostic tool in the investigation of neurological presentations. Whether its routine use after every brain magnetic resonance imaging (MRI) is warranted is debated amongst clinicians, and its usefulness ...
Susana R. Monforte Monteiro, Luisa De Risio, Lisa Alves, An E. Vanhaesebrouck   +3 more
doaj   +1 more source