Results 121 to 130 of about 7,324,524 (245)

Cyclooxygenase-1 and -2 in the different stages of Alzheimer's disease pathology

, 2008
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the deposition of beta amyloid (Abeta) protein and the formation of neurofibrillary tangles. In addition, there is an increase of inflammatory proteins in the brains of AD patients.
Eikelenboom, P., Veerhuis, R, Hoozemans, J. J. M., van Haastert, E. S., Veerhuis, R., Rozemuller, J M, van Haastert, E S, Rozemuller, J. M., Hoozemans, J J M, Eikelenboom, P   +9 more
core   +1 more source

Strengthening Biomarker Research in Canadian Cancer Clinical Trials: A Pathology-Focused White Paper

Current Oncology
Pathology is foundational to biomarker-driven and translational oncology research, yet systemic barriers limit full pathology engagement in Canadian cancer clinical trials, compromising the tissue-based questions such trials are designed to answer.
David F. Schaeffer, Jennifer Chan, Jason Morin, Marie-Christine Guiot, George M. Yousef, Catherine J. Streutker, Harman Sekhon, Madeline Fitzpatrick, Shakeel Virk, Alexander Wyatt, Alan Spatz, Lois Shepherd, Jonathan M. Loree, Mary Kinloch   +13 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Determinants of Safe Behavior among Clinical Pathology Assistants at Dr. Soebandi Regional Hospital Jember, Indonesia

The Indonesian Journal of Occupational Safety and Health
Introduction: Every workplace has potential hazards that can threaten work safety, including clinical pathology laboratories. Work accidents in clinical pathology at Dr. Soebandi Regional Hospital Jember have decreased every year.
Puspita Octaviani, Ragil Ismi Hartanti, Reny Indrayani   +2 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Responsible and ethical clinical practice : a framework for knowledge translation

, 2015
In this paper Belinda Kenny and Susan Block, members of the Speech Pathology Australia Ethics Board, reflect upon the challenges and opportunities facing speech pathologists as they make decisions about client interactions and intervention.
Block, Susan, Kenny, Belinda J. (R19919)
core  

Associations of preorchiectomy hormone levels to testicular germ cell tumor pathology, clinical stage, and size. [PDF]

Asian J Androl, 2021
Pineault KG, Cheaib JG, Herati AS, Pierorazio PM.   +3 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

A Standardized Pathology Report for Gastric Cancer [PDF]

, 2017
Background and Methods : The Gastrointestinal Pathology Study Group of the Korean Society of Pathologists developed a standardized pathology reporting format for gastric cancer in collaboration with the Korean Gastric Cancer Association.
김호근
core