Results 111 to 120 of about 2,215,729 (248)

Review for "Recalling the Pathology of Parkinson’s disease; lacking exact figure of prevalence and genetic evidence in Asia with an alarming outcome: A time to step‐up"

, 2021

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Retinal Hyperreflecting Foci Associate With Cortical Pathology in Multiple Sclerosis [PDF]

, 2022
Marta Pengo, Silvia Miante, Silvia Franciotta, Marta Ponzano, Tommaso Torresin, Francesca Bovis, Francesca Rinaldi, Paola Perini, Martina Saiani, Monica Margoni, Alessandra Bertoldo, Maria Pia Sormani, Elisabetta Pilotto, Edoardo Midena, Paolo Gallo, Marco Puthenparampil   +15 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Gait Progression Over 6 Years in Parkinson’s Disease: Effects of Age, Medication, and Pathology [PDF]

, 2020
Joanna Wilson, Lisa Alcock, Alison J. Yarnall, Sue Lord, Rachael A. Lawson, Rosie Morris, John‐Paul Taylor, David J. Burn, Lynn Rochester, Brook Galna   +9 more
openalex   +1 more source

A New Hierarchy of Research Evidence for Tumor Pathology: A Delphi Study to Define Levels of Evidence in Tumor Pathology [PDF]

, 2023
Richard Colling, Iciar Indave, Javier del Aguila, Ramon Cierco Jiménez, Fiona Campbell, Magdalena Chechlińska, Magdalena Kowalewska, Stefan Holdenrieder, Inga Trulson, Karolina Worf, Marina Pollán, Elena Plans-Beriso, Beatriz Pérez‐Gómez, Oana Craciun, Ester García-Ovejero, Irmina Maria Michałek, K.I. Maslova, Grzegorz Rymkiewicz, Joanna Didkowska, Puay Hoon Tan, Nur Diyana Md Nasir, Nickolas Myles, G. Goldman-Lévy, Dilani Lokuhetty, Ian A. Cree   +24 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Pathology Annual, Vol. 4, 1969 [PDF]

, 1970

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Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Forest Research—Products and Pathology [PDF]

, 1957

openalex   +1 more source

Comparison of Machine Learning Algorithms for the Prediction of Current Procedural Terminology (CPT) Codes from Pathology Reports [PDF]

, 2021
Joshua Levy, Nishitha Vattikonda, Christian C. Haudenschild, Brock C. Christensen, Louis Vaickus   +4 more
openalex   +1 more source