Results 111 to 120 of about 2,892,074 (310)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Retraction: Frequencies of Porphyromonas gingivalis detection in oral-digestive tract tumors

Pathology and Oncology Research, 2023
Pathology and Oncology Research Editorial Office
doaj   +1 more source

Microglial dynamics and emerging therapeutic strategies in CNS homeostasis and pathology

Frontiers in Pharmacology
Microglia, the resident immune cells of the central nervous system (CNS), are highly dynamic and play critical roles in maintaining CNS homeostasis. Under normal conditions, microglia continuously monitor their environment, clear cellular debris, and ...
Jie Cao, Jianqing Yuan, Nanhai Liu, Kai Huang, Mingwei Guo   +4 more
doaj   +1 more source

PATHOLOGY [PDF]

British Journal of Ophthalmology, 1946
openaire   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Erratum: The Role of Time as a Prognostic Factor in Pediatric Brain Tumors: a Multivariate Survival Analysis

Pathology and Oncology Research, 2022
Pathology and Oncology Research Production Office
doaj   +1 more source

The role of gross and microscopic descriptions in pathology reports

, 2021
Background: The implementation of mandatory synoptic templates in the final diagnosis section of pathology reports has been associated with increased uniformity and clarity though the content and format of other pathology report sections have yet to be ...
Bernuetz, Madeline
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Machine learning prediction model for lateral lymph node metastasis in rectal cancer

Frontiers in Gastroenterology
BackgroundThe preoperative diagnosis of lateral lymph node metastasis presents a significant challenge. In this study, we aimed to predict the pathological characteristics of lateral lymph nodes in patients with rectal cancer using preoperative clinical ...
Longchun Dong, Shiyong Du, Hongjie Yang, Hongjie Yang, Hongjie Yang, Hongjie Yang, Xipeng Zhang, Xipeng Zhang, Xipeng Zhang, Xipeng Zhang, Zhichun Zhang, Zhichun Zhang, Zhichun Zhang, Zhichun Zhang, Shuan Geng, Shuan Geng, Shuan Geng, Shuan Geng, Yuanda Zhou, Yuanda Zhou, Yuanda Zhou, Yuanda Zhou, Peng Li, Peng Li, Peng Li, Peng Li, Qingsheng Zeng, Qingsheng Zeng, Qingsheng Zeng, Qingsheng Zeng, Yi Sun, Yi Sun, Yi Sun, Yi Sun, Peishi Jiang   +34 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source