Results 151 to 160 of about 2,661,536 (309)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Strengthening Biomarker Research in Canadian Cancer Clinical Trials: A Pathology-Focused White Paper. [PDF]

Curr Oncol
Schaeffer DF, Chan J, Morin J, Guiot MC, Yousef GM, Streutker CJ, Sekhon H, Fitzpatrick M, Virk S, Wyatt A, Spatz A, Shepherd L, Loree JM, Kinloch M, CCTG Pathology Working Group.   +14 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Ocular pathology /

Comprehensive, yet concise and clinically oriented, the new edition of Ocular Pathology brings you the very latest advances of every aspect of ocular pathology. From updated information on today's imaging techniques, to the implementation of genetic data
Sassani, Joseph W.,author., Yanoff, Myron,author.   +1 more
core  

A novel hierarchical framework elucidating regional differences in α-synuclein and tau co-pathology in military veterans with parkinsonism. [PDF]

J Neuropathol Exp Neurol
Flores Almazan VG, Laborc KF, De Sanctis C, Thorn EL, Goldstein A, Cervera A, Quintana Mora DF, Mendez Y, McGoldrick AC, Chiu LY, Hossain QI, McQuillan S, Lind-Watson K, Walker JM, Walker RH, Nirenberg MJ, Crary JF.   +16 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Aurora Sporealis Vol.02(1)

, 1926
Alumni news magazine of the University of Minnesota Department of Plant Pathology.University of Minnesota: Department of Plant Pathology. (1926). Aurora Sporealis Vol.02(1).
University of Minnesota: Department of Plant Pathology
core  

RETRACTION: MicroRNA-520a Suppresses Pathogenesis and Progression of Non-Small-Cell Lung Cancer through Targeting the RRM2/Wnt Axis

Analytical Cellular Pathology
Analytical Cellular Pathology
doaj   +1 more source

Correction: Clinicopathological profile of basal cell carcinoma: a retrospective study from Limpopo province, South Africa. [PDF]

Clin Exp Med
Manenzhe R, McCusker CP, Mhlongo LN.
europepmc   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source