Results 201 to 210 of about 2,222,221 (260)

Editorial: Exploring molecular mechanisms in cancer through tumor molecular pathology. [PDF]

Front Oncol
Ma W, Zhang H, Liu N, Li C.
europepmc   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Comparative Analysis of Pathology Foundation Models for Automated Detection of Tertiary Lymphoid Structures in Hematoxylin-and-Eosin-Stained Digital Pathology Images. [PDF]

Comput Struct Biotechnol J
Guan M, Sun Y, Belete M, Muthuswamy A, Farma M, Kaufmann J, Lechpammer M, Sridhar S, Higgs BW, Si H.   +9 more
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Amyloid plaques associated with shift in patterns of hippocampal tau pathology in middle age. [PDF]

J Alzheimers Dis
Rodriguez-Reyes RF, Guo H, Luongo M, Gomez-Isaza L, Pletnikova O, Troncoso JC, Morris M.   +6 more
europepmc   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

APOE ε4 influences the widespread TDP-43 pathological subtype in sporadic amyotrophic lateral sclerosis. [PDF]

Acta Neuropathol
Hatano Y, Nakahara A, Tada M, Kakita A, Onodera O, Ishihara T.   +5 more
europepmc   +1 more source

Universal and transferable attacks on pathology foundation models using microscopic perturbations. [PDF]

Light Sci Appl
Wang Y, Yang X, Shen CY, Dong S, Pillar N, Ozcan A.   +5 more
europepmc   +1 more source

Educational Frameworks for Diagnostic Decision-Making in AI-Enhanced Head and Neck Pathology. [PDF]

Head Neck Pathol
Tavares T, Sangalli L, Menon RS, Miller CS, Hochman G.   +4 more
europepmc   +1 more source