Results 51 to 60 of about 2,215,729 (248)

“Porquê suportar o hospício quando poderias ir aos céus?” Thoreau ou uma alternativa à normose

Anglo Saxonica, 2020
In dialogue with Thoreau, we seek to reflect on the limits of the common perception of the world and the possibility of overcoming them by the awakening of consciousness. For this purpose, the concepts of pathology and normality are rethought in light of
Paulo Borges
doaj   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Obesity Worsens Gulf War Illness Symptom Persistence Pathology by Linking Altered Gut Microbiome Species to Long-Term Gastrointestinal, Hepatic, and Neuronal Inflammation in a Mouse Model [PDF]

, 2020
Dipro Bose, Punnag Saha, Ayan Mondal, Brian Fanelli, Ratanesh Seth, Patricia Janulewicz, Kimberly Sullivan, Stephen M. Lasley, Ronnie D. Horner, Rita R. Colwell, Ashok K. Shetty, Nancy G. Klimas, Saurabh Chatterjee   +12 more
openalex   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Histopathological variations of Sclerosing Polycystic Adenoma: A systematic review

Journal of Taibah University Medical Sciences
الملخص: في هذه المراجعة المنهجية، هدفنا إلى تقييم الاختلافات النسيجية المرضية لورم الغدة النكفية المتعدد الكيسات المصلب. تم البحث بشكل شامل في قواعد البيانات، بما في ذلك ''ببميد''، و ''ساينس دايركت''، و ''أوفيد'' ومصادر الأدبيات غير الرسمية.
Syeda Areeba Rehan, MPhil, Oral Pathology, Zainab Niazi, PhD, Oral Pathology, Saeed Alam, FCPS, Tamoor Khan Wazir, FCPS, Fatimah Imran, BDS   +4 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Exportin-T Promotes Breast Cancer Progression via PI3K/AKT/mTOR Signaling Pathway

Journal of Inflammation Research
Zhichao Hou,1 Wenxia Ma,2 Dongliang Ren,1 Ningning Shen,2 Weilin Bi,1 Meiqin Guo,1 Xinzheng Li,1 Yanhong Wang,3 Hongyan Jia4 1Department of Breast Surgery, The Second Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China; 2Department
Hou Z, Ma W, Ren D, Shen N, Bi W, Guo M, Li X, Wang Y, Jia H   +8 more
doaj  

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Bladder Leiomyoma Presenting with Recurrent Cystitis: A Case Report

Research and Reports in Urology
Kazuhiro Fukuda,1 Satoru Kotoda,1 Kaori Fukaya,1 Eisuke Yokota,1 Shigetaka Yamasaki,2 Shigeo Horie3,4 1Department of Urology, Koshigaya Municipal Hospital, Koshigaya, Saitama, Japan; 2Department of Pathology, Tokyo Rinkai Hospital, Tokyo, Japan ...
Fukuda K, Kotoda S, Fukaya K, Yokota E, Yamasaki S, Horie S   +5 more
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