Results 71 to 80 of about 2,222,221 (260)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Hepatoid adenocarcinoma of the lung: a rare case report

Galicia Clínica
Background: Hepatoid adenocarcinoma of the lung (HAL) is a rare type of carcinoma that histologically resembles a primary hepatocellular carcinoma (HCC), leading to a potential misdiagnosis.
Leyre Alonso Gonzalo, Crhistian-Mario Oblitas   +1 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Retraction: Frequencies of Porphyromonas gingivalis detection in oral-digestive tract tumors

Pathology and Oncology Research, 2023
Pathology and Oncology Research Editorial Office
doaj   +1 more source

Microglial dynamics and emerging therapeutic strategies in CNS homeostasis and pathology

Frontiers in Pharmacology
Microglia, the resident immune cells of the central nervous system (CNS), are highly dynamic and play critical roles in maintaining CNS homeostasis. Under normal conditions, microglia continuously monitor their environment, clear cellular debris, and ...
Jie Cao, Jianqing Yuan, Nanhai Liu, Kai Huang, Mingwei Guo   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Erratum: The Role of Time as a Prognostic Factor in Pediatric Brain Tumors: a Multivariate Survival Analysis

Pathology and Oncology Research, 2022
Pathology and Oncology Research Production Office
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Machine learning prediction model for lateral lymph node metastasis in rectal cancer

Frontiers in Gastroenterology
BackgroundThe preoperative diagnosis of lateral lymph node metastasis presents a significant challenge. In this study, we aimed to predict the pathological characteristics of lateral lymph nodes in patients with rectal cancer using preoperative clinical ...
Longchun Dong, Shiyong Du, Hongjie Yang, Hongjie Yang, Hongjie Yang, Hongjie Yang, Xipeng Zhang, Xipeng Zhang, Xipeng Zhang, Xipeng Zhang, Zhichun Zhang, Zhichun Zhang, Zhichun Zhang, Zhichun Zhang, Shuan Geng, Shuan Geng, Shuan Geng, Shuan Geng, Yuanda Zhou, Yuanda Zhou, Yuanda Zhou, Yuanda Zhou, Peng Li, Peng Li, Peng Li, Peng Li, Qingsheng Zeng, Qingsheng Zeng, Qingsheng Zeng, Qingsheng Zeng, Yi Sun, Yi Sun, Yi Sun, Yi Sun, Peishi Jiang   +34 more
doaj   +1 more source