Results 71 to 80 of about 3,729,249 (304)

First-Line Guselkumab Combined with Exclusive Enteral Nutrition in Biologic-Naïve Young‑Onset Crohn’s Disease: A Three-Case Series from China

Journal of Inflammation Research
Sumei Sha,1 Bin Xu,2 Chenyang Qiao,1 Kairuo Wang,1 Le Liu,3 Jie Wu,4 Wenqi Ma,5 Ameng Shi,5 Xin Liu1 1Department of Gastroenterology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2Department of ...
Sha S, Xu B, Qiao C, Wang K, Liu L, Wu J, Ma W, Shi A, Liu X   +8 more
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Histopathological variations of Sclerosing Polycystic Adenoma: A systematic review

Journal of Taibah University Medical Sciences
الملخص: في هذه المراجعة المنهجية، هدفنا إلى تقييم الاختلافات النسيجية المرضية لورم الغدة النكفية المتعدد الكيسات المصلب. تم البحث بشكل شامل في قواعد البيانات، بما في ذلك ''ببميد''، و ''ساينس دايركت''، و ''أوفيد'' ومصادر الأدبيات غير الرسمية.
Syeda Areeba Rehan, MPhil, Oral Pathology, Zainab Niazi, PhD, Oral Pathology, Saeed Alam, FCPS, Tamoor Khan Wazir, FCPS, Fatimah Imran, BDS   +4 more
doaj   +1 more source

CHARACTERISTICS OF INDIVIDUALS UNDERGOING PANEL GENETIC TESTING FOR PRIMARY BRAIN TUMORS [PDF]

, 2018
Background. Currently, there are no genetic testing guidelines for patients with a primary brain tumor (PBT). This population is largely understudied in terms of the family history, tumor grade, pathology, and their relation to genetic contribution.
Azam, Sarah
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Hepatoid adenocarcinoma of the lung: a rare case report

Galicia Clínica
Background: Hepatoid adenocarcinoma of the lung (HAL) is a rare type of carcinoma that histologically resembles a primary hepatocellular carcinoma (HCC), leading to a potential misdiagnosis.
Leyre Alonso Gonzalo, Crhistian-Mario Oblitas   +1 more
doaj   +1 more source

Pathology and viral metagenomics, a recent history [PDF]

, 2013
Human, animal and plant viral pathologies have greatly benefited from recent metagenomics development. Viral metagenomics is a culture-independent approach used to investigate the complete viral genetic populations of a sample.
Albina, Emmanuel, Bernardo, Pauline, Eloit, Marc, Fernandez, Emmanuel, Filloux, Denis, Roumagnac, Philippe   +5 more
core  

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source