Results 81 to 90 of about 3,729,249 (304)

PATHOLOGY [PDF]

open access: yesNeuro-Oncology, 1992
J.-i. Adachi   +199 more
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Microglial dynamics and emerging therapeutic strategies in CNS homeostasis and pathology

open access: yesFrontiers in Pharmacology
Microglia, the resident immune cells of the central nervous system (CNS), are highly dynamic and play critical roles in maintaining CNS homeostasis. Under normal conditions, microglia continuously monitor their environment, clear cellular debris, and ...
Jie Cao   +4 more
doaj   +1 more source

Dental Pathology in Selected Carnivores from Arkansas [PDF]

open access: yes, 1989
The occurrence and kinds of dental pathology in wild carnivore populations in Arkansas were investigated through examination of 1295 skulls of bobcat (Felis rufus), river otter (Lutra canadensis), gray fox (Urocyon cinereoargenteus), coyote (Canis ...
McDaniel, V. Rick   +2 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes. [PDF]

open access: yes, 2019
We demonstrated that an antibiotic cocktail (ABX)-perturbed gut microbiome is associated with reduced amyloid-β (Aβ) plaque pathology and astrogliosis in the male amyloid precursor protein (APP)SWE /presenilin 1 (PS1)ΔE9 transgenic model of Aβ ...
Baufeld, Caroline   +10 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Machine learning prediction model for lateral lymph node metastasis in rectal cancer

open access: yesFrontiers in Gastroenterology
BackgroundThe preoperative diagnosis of lateral lymph node metastasis presents a significant challenge. In this study, we aimed to predict the pathological characteristics of lateral lymph nodes in patients with rectal cancer using preoperative clinical ...
Longchun Dong   +34 more
doaj   +1 more source

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