Results 71 to 80 of about 3,190,326 (311)

Acidified drinking water attenuates motor deficits and brain pathology in a mouse model of a childhood neurodegenerative disorder [PDF]

, 2022
Attila Kovács, Logan M. Langin, José L. González-Hernández, David A. Pearce   +3 more
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Actinomycosis of the Gallbladder in a Young Diabetic Woman with Acute Lithiasis Cholecystitis: A Case Report and Review of the Literature

International Medical Case Reports Journal
Mojgan Akbarzadeh-Jahromi,1 Seyed Mohammad Kazem Tadayyon,2 Sahar Asadi,1 Neda Soleimani,1 Sahand Mohammadzadeh,1 Hossein Afrakhteh3 1Department of Pathology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran; 2Department of ...
Akbarzadeh-Jahromi M, Tadayyon SMK, Asadi S, Soleimani N, Mohammadzadeh S, Afrakhteh H   +5 more
doaj  

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

E-learning in Pathology Education: A Narrative Review and Personal Perspective

European Medical Journal Innovations, 2020
In recent years, E-learning, also known as web-based learning, online learning, computer-assisted instruction, or internet-based learning, has been used frequently in healthcare education programmes. E-Learning has played a significant role in the author’
Maheswari Mukherjee
doaj  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Profile of speech-language pathology care focused on Augmentative and Alternative Communication [PDF]

, 2022
Luana Stanganelli Martinez, Sandra Pires
openalex   +1 more source

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

Nature, 2018
Cellular senescence, which is characterized by an irreversible cell-cycle arrest1 accompanied by a distinctive secretory phenotype2, can be induced through various intracellular and extracellular factors.
Tyler J. Bussian, Asef Aziz, Charlton F. Meyer, Barbara L. Swenson, J. V. van Deursen, D. Baker   +5 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Expression of Concern: Case report: A rare case of tumor-to-tumor metastasis: metastatic lobular breast carcinoma to clear cell renal cell carcinoma

Pathology and Oncology Research, 2023
Pathology & Oncology Research Editorial Office
doaj   +1 more source