Results 81 to 90 of about 3,893,490 (356)

Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy. [PDF]

, 2018
Alzheimer's disease (AD), the most common form of dementia, is characterized by the abnormal accumulation of amyloid plaques and hyperphosphorylated tau aggregates, as well as microgliosis. Hemizygous missense variants in Triggering Receptor Expressed on
Akassoglou, Katerina, Clelland, Claire, Cooper, Yonatan A, Coppola, Giovanni, Davalos, Dimitrios, Gan, Li, Gao, Fuying, Hauduc, Axel, Kodama, Lay, Le, David, Li, Yaqiao, Ludwig, Connor, Sayed, Faten A, Telpoukhovskaia, Maria, Zhan, Lihong, Zhou, Yungui   +15 more
core   +1 more source

PathologyGAN: Learning deep representations of cancer tissue [PDF]

, 2020
We apply Generative Adversarial Networks (GANs) to the domain of digital pathology. Current machine learning research for digital pathology focuses on diagnosis, but we suggest a different approach and advocate that generative models could drive forward ...
Murray-Smith, Roderick, Quiros, Adalberto Claudio, Yuan, Ke   +2 more
core   +2 more sources

The Value of Comparative Pathology [PDF]

, 1977
G. B. D. Scott
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes. [PDF]

, 2019
We demonstrated that an antibiotic cocktail (ABX)-perturbed gut microbiome is associated with reduced amyloid-β (Aβ) plaque pathology and astrogliosis in the male amyloid precursor protein (APP)SWE /presenilin 1 (PS1)ΔE9 transgenic model of Aβ ...
Baufeld, Caroline, Butovsky, Oleg, Dodiya, Hemraj B, Gilbert, Jack A, Gottel, Neil, Kuntz, Thomas, Leibowitz, Jeffrey, Shaik, Shabana M, Sisodia, Sangram S, Zhang, Xiaoqiong, Zhang, Xulun   +10 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Machine learning prediction model for lateral lymph node metastasis in rectal cancer

Frontiers in Gastroenterology
BackgroundThe preoperative diagnosis of lateral lymph node metastasis presents a significant challenge. In this study, we aimed to predict the pathological characteristics of lateral lymph nodes in patients with rectal cancer using preoperative clinical ...
Longchun Dong, Shiyong Du, Hongjie Yang, Hongjie Yang, Hongjie Yang, Hongjie Yang, Xipeng Zhang, Xipeng Zhang, Xipeng Zhang, Xipeng Zhang, Zhichun Zhang, Zhichun Zhang, Zhichun Zhang, Zhichun Zhang, Shuan Geng, Shuan Geng, Shuan Geng, Shuan Geng, Yuanda Zhou, Yuanda Zhou, Yuanda Zhou, Yuanda Zhou, Peng Li, Peng Li, Peng Li, Peng Li, Qingsheng Zeng, Qingsheng Zeng, Qingsheng Zeng, Qingsheng Zeng, Yi Sun, Yi Sun, Yi Sun, Yi Sun, Peishi Jiang   +34 more
doaj   +1 more source

Life After Being a Pathology Department Chair: Issues and Opportunities. [PDF]

, 2016
Although there is a considerable literature on transition of faculty members to the position of department chair, there is a dearth of publications about transitioning from the chair to other activities including retirement.
Bailey, David N, Gorstein, Fred, Lipscomb, Mary F, Sanfilippo, Fred, Wilkinson, David   +4 more
core  

Initial Rapid Pathology Assessment of Kidney Tissue v2

, 2021
Jamie Allen, Carrie Romer, Elizabeth K. Neumann, Maya Brewer, Haichun Yang, Jeffrey M. Spraggins, Danielle Gutierrez   +6 more
openalex   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source