Results 81 to 90 of about 3,834,924 (331)

“Porquê suportar o hospício quando poderias ir aos céus?” Thoreau ou uma alternativa à normose

open access: yesAnglo Saxonica, 2020
In dialogue with Thoreau, we seek to reflect on the limits of the common perception of the world and the possibility of overcoming them by the awakening of consciousness. For this purpose, the concepts of pathology and normality are rethought in light of
Paulo Borges
doaj   +1 more source

Using World-Wide-Web technology for pathology education [PDF]

open access: yes, 1997
In this article, we describe the development of computer-based learning programs for pathology students at Jefferson Medical College. These programs are authored using HTML (HyperText Markup Language), and are available to students on campus and via the ...
Braster, Christopher D   +3 more
core   +1 more source

PathologyGAN: Learning deep representations of cancer tissue [PDF]

open access: yes, 2020
We apply Generative Adversarial Networks (GANs) to the domain of digital pathology. Current machine learning research for digital pathology focuses on diagnosis, but we suggest a different approach and advocate that generative models could drive forward ...
Murray-Smith, Roderick   +2 more
core   +2 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Macrophage autophagy in atherosclerosis [PDF]

open access: yes, 2013
Macrophages play crucial roles in atherosclerotic immune responses. Recent investigation into macrophage autophagy (AP) in atherosclerosis has demonstrated a novel pathway through which these cells contribute to vascular inflammation.
Carnuccio, R.   +5 more
core   +2 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

The development and convergence of co-pathologies in Alzheimer’s disease [PDF]

open access: bronze, 2020
John Robinson   +12 more
openalex   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy. [PDF]

open access: yes, 2018
Alzheimer's disease (AD), the most common form of dementia, is characterized by the abnormal accumulation of amyloid plaques and hyperphosphorylated tau aggregates, as well as microgliosis. Hemizygous missense variants in Triggering Receptor Expressed on
Akassoglou, Katerina   +15 more
core   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

open access: yesMolecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy   +9 more
wiley   +1 more source

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