Results 81 to 90 of about 23,088 (252)
ABSTRACT Top‐down proteomics (TDP) characterizes proteoforms in cells, tissues, and biofluids, in discovery mode and on a global scale, requiring analytical tools with high peak capacity for proteoform separation and high sensitivity for proteoform detection, given the extremely high proteoform complexity and wide proteoform concentration dynamic range.
Guijie Zhu +5 more
wiley +1 more source
Polydatin alleviates adenine-induced nephropathy in mice
Background Adenine-induced nephropathy (AIN) serves as a classic experimental model for studying uric acid-related renal injury, characterized by tubular obstruction, inflammatory cell infiltration, tubular epithelial cell apoptosis, and progressive ...
Tao Sheng +11 more
doaj +1 more source
Recent Advances in Top‐Down Proteomics for Single‐Cell Research
ABSTRACT Individual cells have distinctive molecular characteristics, including biologically relevant proteoforms. Although single‐cell (SC) molecular omics offer unprecedented insights into cellular heterogeneity and function, the characterization of proteoforms in SCs remains an uncharted territory.
Jake A. Melby, Pei Su, Fabio P. Gomes
wiley +1 more source
Paediatric Forensic Medicine and Pathology [PDF]
openaire +3 more sources
Mass Spectrometry‐Based Extracellular Vesicle Proteomics for Biomarker Discovery
ABSTRACT Extracellular vesicle (EV) proteomics has emerged as a powerful platform for decoding intercellular communication and advancing biomarker discovery across human diseases. EVs carry proteins that reflect their cells of origin, offering a minimally invasive window into physiological and pathological processes.
Ya‐Juan Liu, Juan Peng, Chao Kang
wiley +1 more source
ABSTRACT Wooden dentures represent a distinctive form of dental technology uniquely developed in Japan that is no longer in clinical use. Although Edo‐period (1603–1867) wooden dentures are presumed to have achieved sufficient precision, their morphological fit has not been quantitatively evaluated.
Kie Yoshida +3 more
wiley +1 more source
ABSTRACT As top predators, terrestrial carnivores face great risk of pesticide exposure and serve as sentinels of environmental contamination. Additionally, terrestrial carnivores are frequently threatened by intentional or secondary poisoning with highly toxic compounds, such as carbamates and organophosphates.
Marina Pellegrino da Silva +10 more
wiley +1 more source
New Insights In Veterinary Forensic Medicine and Pathology [PDF]
Over the last years, the knowledge on the veterinary forensic medicine and pathology has experienced a rapid increase as evidenced by number of peer- reviewed publications, textbooks and inclusion of the topic in many veterinary medical conferences. However, most of the information in veterinary forensic medicine is still acquired by human forensic ...
openaire +2 more sources
This essay introduces the themed cluster of articles, ‘Towards a linguistic anthropology of AI’. The advent of artificial intelligence (AI), especially in large language models capable of producing coherent discourse mimicking conversational interaction, is exerting unprecedented pressure on prevailing concepts of language, personhood, and the human ...
Webb Keane, Constantine V. Nakassis
wiley +1 more source
This case note critically examines the January 2026 High Court judgment in The King (on the application of The Howard League for Penal Reform) v The Secretary of State for Justice which dismissed a judicial review challenging the expansion of the use of PAVA spray in Young Offender Institutions (YOIs) in England.
Raymond Arthur
wiley +1 more source

