Results 71 to 80 of about 1,115,813 (356)

Shift of N-MYC Oncogene Expression in AML Patients Carrying the FLT3-ITD Mutation

Pathophysiology, 2023
Mutations in the FLT3 gene not only lead to abnormalities in its structure and function, but also affect the expression of other genes involved in leukemogenesis.
Konstantin Bogdanov, Ekaterina Kudryavtseva, Yulia Fomicheva, Irina Churkina, Elza Lomaia, Larisa Girshova, Yuri Osipov, Andrey Zaritskey   +7 more
doaj   +1 more source

Pathophysiology of proteinuria [PDF]

Kidney International, 2003
Proteinuria is consequence of two mechanisms: the abnormal transglomerular passage of proteins due to increased permeability of glomerular capillary wall and their subsequent impaired reabsorption by the epithelial cells of the proximal tubuli. In the various glomerular diseases, the severity of disruption of the structural integrity of the glomerular ...
D'Amico, Giuseppe, Bazzi, Claudio
openaire   +3 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Polymicrobial Infection (Gram-Positive and Gram-Negative) Exacerbates Systemic Inflammatory Response Syndrome in a Conscious Swine Extremity Trauma Model

Pathophysiology
Background/Objectives: Extremity trauma represents a significant proportion of battlefield injuries and is prevalent in polytraumatized patients from accidents.
Catharina C. Gaeth, Travis R. Madaris, Jamila M. Duarte, Amber M. Powers, Christina M. Sandoval, Stefanie M. Shiels, Randolph Stone   +6 more
doaj   +1 more source

Shock-Associated Systemic Inflammation in Amniotic Fluid Embolism, Complicated by Clinical Death

Pathophysiology, 2023
Background: Amniotic fluid embolism (AFE) is one of the main causes of maternal mortality in developed countries. The most critical AFE variants may be considered from the perspective of systemic inflammation (SI), a general pathological process that ...
Anatoly Brazhnikov, Natalya Zotova, Liliya Solomatina, Alexey Sarapultsev, Alexey Spirin, Evgeni Gusev   +5 more
doaj   +1 more source

Spinal Cord Injury: Pathophysiology, Multimolecular Interactions, and Underlying Recovery Mechanisms

International Journal of Molecular Sciences, 2020
Spinal cord injury (SCI) is a destructive neurological and pathological state that causes major motor, sensory and autonomic dysfunctions. Its pathophysiology comprises acute and chronic phases and incorporates a cascade of destructive events such as ...
A. Anjum, Muhammad Da'in Yazid, Muhammad Fauzi Daud, Jalilah Idris, A. M. Ng, Amaramalar Selvi Naicker, Ohnmar Htwe Rashidah Ismail, Ramesh Kumar Athi Kumar, Y. Lokanathan   +8 more
semanticscholar   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Applied pathophysiology : a conceptual approach

, 2023
xxiv, 576 hlm : 22,5 x 28,5 ...
Judi Nath
core  

Pulsed-Field Ablation Is Associated with Lower Endothelial Injury and Procedure Time Compared to Cryoballoon Ablation in Paroxysmal Atrial Fibrillation

Pathophysiology
Background: Thromboembolic events, though infrequent, remain a significant complication of atrial fibrillation (AF) ablation, largely related to endothelial damage.
Josip Katic, Ante Anic, Toni Breskovic, Josip Andelo Borovac, Branka Kresic, Daniela Supe-Domic, Marko Kumric, Josko Bozic, Zrinka Jurisic   +8 more
doaj   +1 more source

A Narrative Review on the Pathophysiology of Preeclampsia

International Journal of Molecular Sciences
Preeclampsia (PE) is a multifactorial pregnancy disorder characterized by hypertension and proteinuria, posing significant risks to both maternal and fetal health.
Johnatan Torres-Torres, S. Espino-y-Sosa, R. Martínez-Portilla, H. Borboa-Olivares, Guadalupe Estrada-Gutierrez, Sandra Acevedo-Gallegos, Erika Ruiz-Ramirez, Martha Velasco-Espin, Pablo Cerda-Flores, Andrea Ramirez-Gonzalez, L. Rojas-Zepeda   +10 more
semanticscholar   +1 more source