Results 61 to 70 of about 1,115,813 (356)

Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression

Biological Psychiatry, 2009
Recognition that inflammation may represent a common mechanism of disease has been extended to include neuropsychiatric disorders including major depression.
Andrew H. Miller, V. Maletić, C. Raison
semanticscholar   +1 more source

Pathophysiology, diagnosis, and management of endometriosis

British medical journal, 2022
Endometriosis affects approximately 190 million women and people assigned female at birth worldwide. It is a chronic, inflammatory, gynecologic disease marked by the presence of endometrial-like tissue outside the uterus, which in many patients is ...
A. Horne, S. Missmer
semanticscholar   +1 more source

Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

Nature
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4.
Ken Suzuki, K. Hatzikotoulas, L. Southam, Henry J. Taylor, Xianyong Yin, Kimberly M. Lorenz, Ravi Mandla, A. Huerta-Chagoya, Giorgio E. M. Melloni, S. Kanoni, N. W. Rayner, O. Bocher, A. Arruda, K. Sonehara, S. Namba, Simon Lee, Michael H. Preuss, Lauren E. Petty, Philip H. Schroeder, Brett Vanderwerff, M. Kals, F. Bragg, Kuang Lin, Xiuqing Guo, Weihua Zhang, Jie Yao, Young Jin Kim, Mariaelisa Graff, F. Takeuchi, J. Nano, A. Lamri, M. Nakatochi, Sanghoon Moon, Robert A. Scott, J. Cook, Jung-Jin Lee, Ian Pan, D. Taliun, E. Parra, Jin-Fang Chai, L. Bielak, Y. Tabara, Y. Hai, G. Thorleifsson, N. Grarup, T. Sofer, M. Wuttke, C. Sarnowski, C. Gieger, Darryl Nousome, S. Trompet, S. Kwak, J. Long, Meng Sun, L. Tong, Wei-Min Chen, Suraj S Nongmaithem, R. Noordam, V. J. Lim, C. H. Tam, Yoonjung Yoonie Joo, Chien-Hsiun Chen, L. Raffield, B. Prins, A. Nicolas, L. Yanek, Guanjie Chen, J. Brody, E. Kabagambe, Ping An, A. Xiang, Hyeok Sun Choi, B. Cade, Jingyi Tan, K. Broadaway, A. Williamson, Zoha Kamali, J. Cui, Manonanthini Thangam, Linda S. Adair, A. Adeyemo, C. Aguilar-Salinas, T. Ahluwalia, S. Anand, Alain G. Bertoni, J. Bork-Jensen, Ivan Brandslund, Thomas A. Buchanan, C. Burant, A. Butterworth, M. Canouil, Juliana C N Chan, Li Chang, M. Chee, Ji Chen, Shyh-Huei Chen, Yuan-Tsong Chen, Zhengmin Chen, L. Chuang, Mary Cushman, J. Danesh, Swapan K. Das, H. J. de Silva, G. Dedoussis, Latchezar Dimitrov, A. Doumatey, S. Du, Qing Duan, K.-U. Eckardt, L. Emery, Daniel S. Evans, M. Evans, K. Fischer, James S Floyd, Ian Ford, O. Franco, T. Frayling, B. Freedman, P. Genter, H. Gerstein, V. Giedraitis, C. González‐Villalpando, M. González-Villalpando, P. Gordon-Larsen, Myron Gross, Lindsay A Guare, S. Hackinger, L. Hakaste, Sohee Han, A. Hattersley, C. Herder, M. Horikoshi, A. Howard, Willa A. Hsueh, Mengna Huang, Wei Huang, Y. Hung, M. Y. Hwang, C. Hwu, S. Ichihara, M. Ikram, M. Ingelsson, Md. Tariqul Islam, M. Isono, Hye-Mi Jang, F. Jasmine, Guozhi Jiang, J. Jonas, T. Jørgensen, Frederick K. Kamanu, Fouad R. Kandeel, A. Kasturiratne, Tomohiro Katsuya, V. Kaur, T. Kawaguchi, Jacob M. Keaton, Abel N. Kho, C. Khor, M. Kibriya, Duk-Hwan Kim, F. Kronenberg, J. Kuusisto, Kristi Läll, Leslie A. Lange, K. Lee, Myung-Shik Lee, N. Lee, Aaron Leong, Liming Li, Yun Li, R. Li-Gao, Symen Ligthart, Cecilia M. Lindgren, A. Linneberg, Ching-Ti Liu, Jianjun Liu, A. Locke, T. Louie, J. Luan, A. Luk, Xi Luo, Jun Lv, J. Lynch, V. Lyssenko, Shiro Maeda, Vasiliki Mamakou, S. R. Mansuri, Koichi Matsuda, T. Meitinger, Olle Melander, A. Metspalu, Huan Mo, Andrew D. Morris, Filipe A. Moura, Jerry L. Nadler, M. Nalls, Uma Nayak, I. Ntalla, Y. Okada, L. Orozco, Sanjay R. Patel, Snehal Patil, P. Pei, Mark A. Pereira, Annette Peters, F. Pirie, H. Polikowsky, Bianca C. Porneala, Gauri Prasad, L. Rasmussen-Torvik, Alexander P. Reiner, M. Roden, Rebecca R. Rohde, K. Roll, C. Sabanayagam, K. Sandow, A. Sankareswaran, Naveed Sattar, S. Schönherr, M. Shahriar, Botong Shen, Jinxiu Shi, Dong Mun Shin, N. Shojima, Jennifer A Smith, W. So, A. Stančáková, V. Steinthorsdottir, A. Stilp, K. Strauch, K. Taylor, Barbara Thorand, U. Thorsteinsdóttir, B. Tomlinson, Tam C. Tran, F. Tsai, Jaakko Tuomilehto, Teresa Tusié-Luna, M. Udler, A. Valladares-Salgado, Rob M. van Dam, J. V. van Klinken, Rohit Varma, Niels Wacher-Rodarte, Eleanor Wheeler, A. R. Wickremasinghe, Ko Willems van Dijk, Daniel Witte, C. Yajnik, Kenichi Yamamoto, Kenichi Yamamoto, Kyungheon Yoon, Canqing Yu, Jian-Min Yuan, Salim Yusuf, M. Zawistowski, Liang Zhang, Wei Zheng, L. Raffel, M. Igase, Eli Ipp, S. Redline, Yoon Shin Cho, L. Lind, M. Province, M. Fornage, C. Hanis, E. Ingelsson, A. Zonderman, B. Psaty, Ya-Xing Wang, C. Rotimi, Diane M. Becker, Fumihiko Matsuda, Yongmei Liu, M. Yokota, S. Kardia, P. Peyser, J. Pankow, J. Engert, A. Bonnefond, P. Froguel, James G Wilson, W. H. Sheu, Jer-Yuarn Wu, M. Hayes, R. Ma, Tien Y. Wong, D. Mook-Kanamori, T. Tuomi, G. Chandak, F. Collins, D. Bharadwaj, Guillaume Paré, M. Sale, H. Ahsan, A. Motala, X. Shu, K. Park, J. Jukema, M. Cruz, Yii-DerIda Chen, S. Rich, R. Mckean-Cowdin, H. Grallert, Ching-Yu Cheng, M. Ghanbari, E. Tai, José E Dupuis, Norihiro Kato, M. Laakso, A. Köttgen, Woon-Puay Koh, D. Bowden, Colin N. A. Palmer, J. Kooner, C. Kooperberg, Simin Liu, Kari E. North, D. Saleheen, T. Hansen, O. Pedersen, N. Wareham, Juyoung Lee, Bong-Jo Kim, I. Millwood, R. Walters, K. Stefánsson, E. Ahlqvist, M. Goodarzi, K. Mohlke, C. Langenberg, C. Haiman, Ruth J. F. Loos, J. C. Florez, Daniel J. Rader, Marylyn D. Ritchie, Sebastian Zöllner, R. Mägi, N. Marston, C. Ruff, D. V. van Heel, S. Finer, Joshua C. Denny, T. Yamauchi, Takashi Kadowaki, J. C. Chambers, M. Ng, Xueling Sim, J. Below, P. Tsao, Kyong-Mi Chang, M. McCarthy, James B. Meigs, A. Mahajan, Cassandra N. Spracklen, Josep M. Mercader, M. Boehnke, J. Rotter, Marijana Vujković, B. Voight, A. P. Morris, E. Zeggini   +362 more
semanticscholar   +1 more source

Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions

Circulation Research, 2022
Intracerebral hemorrhage (ICH) is a devastating form of stroke with high morbidity and mortality. This review article focuses on the epidemiology, cause, mechanisms of injury, current treatment strategies, and future research directions of ICH. Incidence
J. Magid-Bernstein, R. Girard, Sean Polster, Abhinav Srinath, Sharbel Romanos, I. Awad, Lauren H. Sansing   +6 more
semanticscholar   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Viral pathophysiology of multiple sclerosis: A role for Epstein-Barr virus infection?

, 2011
Multiple sclerosis (MS) is the most common inflammatory demyelinating and degenerative disease of the CNS. The cause of MS is unknown but environmental risk factors are implicated in MS.
Marta, M, Gavin Giovannoni, Maghzi, A-H, Isabel Bosca, Cosimo Maggiore, Monica Marta, Etemadifar, M, Ruth Dobson, Maggiore, C, Bosca, I, Masoud Etemadifar, Meier, U-C, Ute-Christiane Meier, Dobson, R, Giovannoni, G, Amir-Hadi Maghzi   +15 more
core   +1 more source

Clinical Characteristics of 6102 Asymptomatic and Mild Cases for Patients with COVID-19 in Indonesia

Pathophysiology, 2023
Background: The COVID-19 pandemic has led to a rise in confirmed cases, making epidemiological studies crucial for identifying the source of transmission and developing effective treatment methods.
Erwin Astha Triyono, Joni Wahyuhadi, Christijogo Soemartono Waloejo, Dimas Aji Perdana, Nabilah, Sisilia Dewanti, Amal Arifi Hidayat, Michael Austin Pradipta Lusida, Fani Sarasati, Ngurah Arie Kapindra Dharma, Muhammad Ikhtiar Zaki Al Razzak, Tanri Hadinata Wiranegara, Nurarifah Destianizar Ali   +12 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Pathophysiology, Management, and Therapeutics in Subarachnoid Hemorrhage and Delayed Cerebral Ischemia: An Overview

Pathophysiology, 2023
Subarachnoid hemorrhage (SAH) is a type of hemorrhagic stroke resulting from the rupture of an arterial vessel within the brain. Unlike other stroke types, SAH affects both young adults (mid-40s) and the geriatric population.
Henry W. Sanicola, Caleb E. Stewart, Patrick Luther, Kevin Yabut, Bharat Guthikonda, J. Dedrick Jordan, J. Steven Alexander   +6 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source