Results 91 to 100 of about 3,311,692 (342)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Modeling Molecular Pathways of Neuronal Ischemia [PDF]
, 2014 Neuronal ischemia, the consequence of a stroke (cerebrovascular accident), is a condition of reduced delivery of nutrients to brain neurons. The brain consumes more energy per gram of tissue than any other organ, making continuous blood flow critical.
Zachary H, Taxin +4 more
openaire +2 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
HeliyonThis research examines the impacts of climate change and socio-economic variables on the hydrological cycle, reservoir water management, and hydropower capacity at the Gezhouba Dam. The Gezhouba Dam serves as a crucial hydroelectric power station and dam,
Chenyang Xiao, Mohammad Mohammaditab
doaj +1 more source
Phase-Field Reaction-Pathway Kinetics of Martensitic Transformations in a Model Fe3Ni Alloy
, 2010 A three-dimensional phase-field approach to martensitic transformations that uses reaction pathways in place of a Landau potential is introduced and applied to a model of Fe3Ni.
Caucci, Anna Maria +3 more
core +3 more sources
Kinetic modelling of plant metabolic pathways [PDF]
Journal of Experimental Botany, 2012 This paper provides a review of kinetic modelling of plant metabolic pathways as a tool for analysing their control and regulation. An overview of different modelling strategies is presented, starting with those approaches that only require a knowledge of the network stoichiometry; these are referred to as structural.
openaire +2 more sources
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
A mathematical model of the tetrapyrrole biosynthesis pathway [PDF]
, 2007 The tetrapyrrole biosynthesis pathway is a key part in chlorophyll production and is essential for plant survival. It involves numerous interacting compounds and, crucially, light.
Feugier, Francois +3 more
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