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Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda +12 more
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Biochemical Pathways and Modeling
Clinical Obstetrics & Gynecology, 2020The precise etiology of the biochemical changes and the resulting constellation of symptoms seen in polycystic ovary syndrome (PCOS) has remained a mystery. Despite advances in our knowledge, the pathogenesis and alterations in the biochemical pathways underlying this disease are still not fully understood.
Anthony, Deangelis +3 more
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Gene Regulation Pathway Modeling
2020 9th Mediterranean Conference on Embedded Computing (MECO), 2020Gene regulation is a process by which cells regulate the production of proteins. The purpose of this paper is to investigate how the cell will react if the four basic molecules included in the gene regulation pathway change in specific cases using MATLAB's SimBiology application.
Azra Cutuk +3 more
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Refining the quantitative pathway of the Pathways to Mathematics model
Journal of Experimental Child Psychology, 2015In the current study, we adopted the Pathways to Mathematics model of LeFevre et al. (2010). In this model, there are three cognitive domains--labeled as the quantitative, linguistic, and working memory pathways--that make unique contributions to children's mathematical development.
Carla Sowinski +5 more
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Modelling Computerised Clinical Pathways
1998Since the mid 1980s, paper clinical pathways have been used in defining the road map of patient care. They have been used with varying degree of success for providing more cost-effective healthcare and helped to establish quality improvement models for healthcare delivery.
Stephen Chu 0001, Branko Cesnik
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A Spectrum of Models of Signaling Pathways
ChemInform, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
Sharat J, Vayttaden +2 more
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Mathematical models of metabolic pathways
Current Opinion in Biotechnology, 1999There have been recent advances in metabolic flux analysis. In particular, the marriage of traditional flux balancing with NMR isotopomer distribution analysis holds great promise for the detailed quantification of physiology. Nevertheless, flux analysis yields only static snap-shots of metabolism.
Varner J, Ramkrishna D
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Logic models of pathway biology
Drug Discovery Today, 2008Living systems seamlessly perform complex information processing and control tasks using combinatorially complex sets of biochemical reactions. Drugs that therapeutically modulate the biological processes of disease are developed using single protein target strategies, often with limited knowledge of the complex underlying role of the targets ...
Watterson, S., Marshall, S., Ghazal, P.
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Modelling the dynamics of signalling pathways
Essays in Biochemistry, 2008In the present chapter we discuss methodologies for the modelling, calibration and validation of cellular signalling pathway dynamics. The discussion begins with the typical range of techniques for modelling that might be employed to go from the chemical kinetics to a mathematical model of biochemical pathways.
Sreenath, SN Sreenath, Sree N. +2 more
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