Results 101 to 110 of about 10,535,177 (317)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Improving exposure assessment of complex hydrocarbon mixtures in the aquatic environment [PDF]

, 2011
Polycyclic Aromatic Hydrocarbons (PAHs) and oil are complex organic mixtures which are ubiquitously present in the aquatic environment. To prevent adverse effects on organisms exposed to these contaminants adequate risk assessment is of vital importance.
Dep IRAS, Risk Assessment of Toxic and Immunomodulatory Agents, Muijs, B.   +2 more
core   +1 more source

Risk Impact Pathway Analysis (RIPA): A Dynamic Risk Assessment Framework for Interdependent Critical Infrastructures

International Journal of Information Security
Abstract Critical Infrastructures (CI) are increasingly interdependent, forming complex dependency networks where disruptions can propagate across sectors and amplify systemic risk. Conventional risk assessment methods are limited by evaluating components in isolation and neglecting how interdependencies shape cascading exposure.
Fatimah Faraji, Haralambos Mouratidis, Abdullah Al-Zakwani   +2 more
openaire   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Quantitative exposure assessment in community-based studies [PDF]

, 2012
Occupational epidemiology focuses on the associations between exposures at the workplace and disease outcomes, essentially concerned with the prevention of disease.
Peters, S.M., Dep IRAS, Risk Assessment of Toxic and Immunomodulatory Agents   +2 more
core   +1 more source

20220113_Advice RAG_use of RATs and nasal samples for Omicron_NL

, 2022
RAG Advice ...
Risk Assessment Group
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Exposure and risk assessment of dioxins and PCBs in humans [PDF]

, 2010
The research described in this thesis was conducted to address health risks associated with occupational exposure to chlorophenoxy herbicides and dioxins (especially TCDD), with a special focus on specific health outcomes (cause specific mortality and ...
Dep IRAS, Boers, D., Risk Assessment of Toxic and Immunomodulatory Agents   +2 more
core   +1 more source

Cumulative risk assessment as the pathway to public health protection for behavioral neurotoxicity

NeuroToxicology
The formulation of adverse outcome pathways (AOPs) based on high-throughput in vitro new approach methods linking biochemical/mechanistic data with an apical endpoint considered an adverse outcome (AO), is increasingly proposed to accelerate the process of risk assessment for environmental chemical exposures.
Deborah A. Cory-Slechta, Cynthia J. Downs, Marissa Sobolewski   +2 more
openaire   +2 more sources