Results 91 to 100 of about 10,535,177 (317)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans [PDF]

, 2012
The role that in vitro systems can play in toxicological risk assessment is determined by the appropriateness of the chosen methods, with respect to the way in which in vitro data can be extrapolated to the in vivo situation.
Testai, E., Dep IRAS, Daneshian, M., Zurlo, J., Kramer, N.I., Leist, M., Risk Assessment of Toxic and Immunomodulatory Agents, Vandebriel, R.J., Goldberg, A.M., Seibert, H., Heneweer, M., Blaauboer, B.J., Boekelheide, K., Dingemans, M.M.L., Yager, J.D., Clewell, H.J., Jaworska, J.   +16 more
core  

Pathways to violent extremism and risk assessment of terror detainees

European Psychiatry, 2017
IntroductionViolent extremism has become an important challenge for forensic professionals in prisons. In Belgium, cities like Brussels and Antwerp saw the rise of recruitment hotspots for violent extremism and foreign fighters. Prisons are well-known places where radicalization occurs.
openaire   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Development of a breast cancer risk assessment and primary prevention pathway for women aged 30-39 years: Views of UK primary care providers on the role of primary care.

PLoS ONE
BackgroundIdentifying women aged 30-39 years at increased risk of developing breast cancer would allow them to receive screening and prevention offers. For this to be feasible, the practicalities of organising risk assessment and primary prevention must ...
Sarah Hindmarch, Louise Gorman, Juliet A Usher-Smith, Victoria G Woof, Sacha J Howell, David P French   +5 more
doaj   +1 more source

Human Health Risk Assessment of Chlorinated Hydrocarbons in Groundwater Based on Multi-Pathway Analysis

Toxics
The rapid development of the global chemical industry has led to widespread groundwater contamination, with frequent pollution incidents posing severe threats to water safety.
Yidi Wang, Guilan Li, Xiaohan Li, Ye Yang, Kaifang Ding, Shilu Xing, Yilong Zhang, Luxing Zhang   +7 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Construction of an adverse outcome pathway framework for arsenic-induced lung cancer using a network-based approach

Ecotoxicology and Environmental Safety
Environmental pollutants are considered as a cause of tumorigenesis, but approaches to assess their risk of causing tumors remain insufficient. As an alternative approach, the adverse outcome pathway (AOP) framework is used to assess the risk of tumors ...
Cheng Cheng, Bowen Fan, Yi Yang, Peiwen Wang, Meng Wu, Haibo Xia, Binafsha Manzoor Syed, Hao Wu, Qizhan Liu   +8 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Pathway-Based Approaches for Environmental Monitoring and Risk Assessment [PDF]

Chemical Research in Toxicology, 2016
Ankley, Gerald, Escher, Beate, Hartung, Thomas, Shah, Imran   +3 more
openaire   +8 more sources