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Stress response pathways, toxicity pathways and adverse outcome pathways [PDF]
Archives of Toxicology, 2012 The aim of this editorial is to address ambiguities and misconceptions regarding the terms stress response pathways, toxicity pathways and adverse outcome pathways. A large number of tightly regulated stress response pathways have evolved to allow cells to cope with and manage different types of cell stress. The purpose of these pathways is to maintain
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Pharmacogenetics and Genomics, 2010 The thiopurine drugs are purine antimetabolites widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g. Crohn’s disease and rheumatoid arthritis) and of organ transplant recipients. As inactive prodrugs, 6-mercaptopurine (6-MP), 6-thioguanine (6-TG) and azathioprine require intracellular activation, catalyzed by ...
Gianluigi Zaza +11 more
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Associative memory stored by functional novel pathway rather than modifications of preexisting neuronal pathways [PDF]
, 2006 Associative conditioning involves changes in the processing pathways activated by sensory information to link the conditioned stimulus (CS) to the conditioned behavior.
Benjamin, Paul R +3 more
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The Public Historian, 2019 Using oral history research under the direction of the Queer Newark Oral History Project, this essay explores how contemporary black lesbian entrepreneurs in the city of Newark, New Jersey, are engaged in entrepreneurial practices that resist patterns of gentrification.
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Building Data-Driven Pathways From Routinely Collected Hospital Data:A Case Study on Prostate Cancer [PDF]
, 2015 Background: Routinely collected data in hospitals is complex, typically heterogeneous, and scattered across multiple Hospital Information Systems (HIS).
Adriansyah, A +8 more
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An optimization model for metabolic pathways [PDF]
, 2009 This article is available open access through the publisher’s website through the link below. Copyright @ The Author 2009.Motivation: Different mathematical methods have emerged in the post-genomic era to determine metabolic pathways.
Arita +28 more
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Implementing pediatric inpatient asthma pathways. [PDF]
, 2021 ObjectivePathways are succinct, operational versions of evidence-based guidelines. Studies have demonstrated pathways improve quality of care for children hospitalized with asthma, but we have limited information on other key factors to guide hospital ...
Cabana, Michael D +5 more
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Clinical Pathways to Ethically Substantive Autonomy [PDF]
, 2013 There is no shortage of support for the idea that ethics should be incorporated into the academic and professional curriculum. There is a difference, however, between, on the one hand, teaching professionals about ethics, and, on the other, demanding ...
Drake, Philip, Toddington, Stuart
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Modulation of neurotrophic signaling pathways by polyphenols [PDF]
, 2015 Polyphenols are an important class of phytochemicals, and several lines of evidence have demonstrated their beneficial effects in the context of a number of pathologies including neurodegenerative disorders such as Alzheimer's and Parkinson's disease. In
Firuzi, Omidreza +3 more
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Pediatric Blood &Cancer, EarlyView.Abstract Background Sickle cell disease (SCD) is an autosomal recessive hemoglobinopathy affecting millions of individuals worldwide. The clinical expression and psychosocial burden of SCD vary widely across geographical, cultural, and healthcare system contexts, underscoring the need for setting‐specific approaches to assessment.
Desiré Fantasia +7 more
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