Results 1 to 10 of about 5,776,246 (295)

Improvement in Depression Symptoms Measured by Montgomery-Åsberg Depression Rating Scale and Quick Inventory of Depressive Symptomatology-Self Rated Items after Randomised Double-blind COMP360 Psilocybin Therapy for Treatment-resistant Depression

European Psychiatry, 2023
Introduction COMP360 is a synthetic, proprietary, purified form of psilocybin in development for treatment-resistant depression (TRD) with FDA Breakthrough Therapy designation.
G. M. Goodwin, L. Marwood, S. Mistry, A. Nowakowska, H. Simmons, J. Tsai, S. Williams, M. B. Young, E. Malievskaia   +8 more
doaj   +1 more source

The Complex Genetic and Epigenetic Regulation of the Nrf2 Pathways: A Review

Antioxidants, 2023
Nrf2 is a major transcription factor that significantly regulates—directly or indirectly—more than 2000 genes. While many of these genes are involved in maintaining redox balance, others are involved in maintaining balance among metabolic pathways that ...
Joe M. McCord, Bifeng Gao, Brooks M. Hybertson   +2 more
doaj   +1 more source

Clinic for Multimorbidity: An Innovative Approach to Integrate General Practice and Specialized Health Care Services

International Journal of Integrated Care, 2023
Introduction: Caring for patients with multimorbidity in general practice is increasing in amount and complexity. To integrate care for patients with multimorbidity and to support general practitioners (GPs), the Clinic for Multimorbidity (CM) was ...
Cathrine Bell, Peter Vedsted, Dorte Gunver Adsersen Kraus, Ulrich Fredberg, Linda Jeffery, Marianne Bjørn Dahlgaard, Rikke Aarhus, Charlotte Weiling Appel   +7 more
doaj   +1 more source

Reliability, usability and identified need for home-based cardiometabolic health self-assessment during the COVID-19 pandemic in Soweto, South Africa

Scientific Reports, 2022
A major obstacle to tackling the growing burden of chronic disease in South Africa is lack of testing, particularly where individuals face multiple barriers to accessing health services.
Clara Calvert, Andrea Kolkenbeck-Ruh, Simone H. Crouch, Larske M. Soepnel, Lisa J. Ware   +4 more
doaj   +1 more source

Direct-access to sonographic diagnosis of deep vein thrombosis in general practice: a descriptive cohort study

BMC Family Practice, 2020
Background Suspicion of deep vein thrombosis (DVT) is common and requires urgent and efficient investigation due to hazardous prognosis. The traditional diagnostic pathway can be complex and time-consuming, and innovative solutions may provide easy ...
Charlotte W. Appel, Annette M. Balle, Mads M. Krintel, Axel Vittrup, Agnete H. Nielsen, Peter Vedsted   +5 more
doaj   +1 more source

Obesity, hypertension, and tobacco use associated with left ventricular remodeling and hypertrophy in South African women: Birth to Twenty Plus Cohort

BMC Cardiovascular Disorders, 2022
Background Left ventricular hypertrophy (LVH) is a marker of increased risk in developing future life-threatening cardiovascular disease (CVD), however, it is unclear how CVD risk factors, such as obesity, blood pressure (BP), and tobacco use, are ...
Andrea Kolkenbeck-Ruh, Larske M. Soepnel, Simone H. Crouch, Sanushka Naidoo, Wayne Smith, Shane A. Norris, Justine Davies, Lisa J. Ware   +7 more
doaj   +1 more source

Phytochemical Combination PB125 Activates the Nrf2 Pathway and Induces Cellular Protection against Oxidative Injury

Antioxidants, 2019
Bioactive phytochemicals in Rosmarinus officinalis, Withania somnifera, and Sophora japonica have a long history of human use to promote health. In this study we examined the cellular effects of a combination of extracts from these plant sources based on
Brooks M. Hybertson, Bifeng Gao, Swapan Bose, Joe M. McCord   +3 more
doaj   +1 more source

Socioeconomic position, perceived weight, lifestyle risk, and multimorbidity in young adults aged 18 to 35 years: a Multi-country Study

BMC Public Health, 2023
Background Multimorbidity-risk is established early in life, therefore reducing modifiable risk factors such as overweight or obesity may, in part, tackle the burden of multimorbidity in later life.
Ashleigh Craig, Asanda Mtintsilana, Witness Mapanga, Siphiwe N. Dlamini, Shane A. Norris   +4 more
doaj   +1 more source

Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62

eLife, 2016
SQSTM1 is an adaptor protein that integrates multiple cellular signaling pathways and whose expression is tightly regulated at the transcriptional and post-translational level.
Rowena DeJesus, Francesca Moretti, Gregory McAllister, Zuncai Wang, Phil Bergman, Shanming Liu, Elizabeth Frias, John Alford, John S Reece-Hoyes, Alicia Lindeman, Jennifer Kelliher, Carsten Russ, Judith Knehr, Walter Carbone, Martin Beibel, Guglielmo Roma, Aylwin Ng, John A Tallarico, Jeffery A Porter, Ramnik J Xavier, Craig Mickanin, Leon O Murphy, Gregory R Hoffman, Beat Nyfeler   +23 more
doaj   +1 more source

The nuclear receptor CAR (NR1I3) regulates serum triglyceride levels under conditions of metabolic stress

Journal of Lipid Research, 2009
The nuclear receptor constitutive androstane receptor (CAR) (NR1I3) regulates hepatic genes involved in xenobiotic detoxification as well as genes involved in energy homeostasis.
Jodi M. Maglich, David C. Lobe, John T. Moore   +2 more
doaj   +1 more source