Results 121 to 130 of about 7,950,605 (408)

Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours

Cell & Bioscience, 2020
The PI3 K/AKT/mTOR signalling pathway plays an important role in the regulation of signal transduction and biological processes such as cell proliferation, apoptosis, metabolism and angiogenesis.
Fei Xu, Lixin Na, Yanfei Li, Linjun Chen
semanticscholar   +1 more source

Perceived treatment burden and health-related quality of life in association with healthcare utilisation among patients attending multiple outpatient clinics

Health and Quality of Life Outcomes
Introduction Patients with multimorbidity who frequently require healthcare may experience a higher treatment burden. In this study, we investigated whether high perceived treatment burden and low perceived health-related quality of life (HRQoL) were ...
Cathrine Bell, Charlotte Weiling Appel, Asger Roer Pedersen, Peter Vedsted   +3 more
doaj   +1 more source

24-hour access outpatient clinic for patients with exacerbation of chronic disease: a before-after cohort study of differences in acute healthcare utilisation

BMC Health Services Research, 2018
Background Chronic diseases are becoming more common due to an increasing ageing population. Patients with chronic conditions managed in outpatient clinics account for a large share of healthcare costs.
Anders Damgaard Møller, David Høyrup Christiansen, Cathrine Bell, Ulrich Fredberg, Peter Vedsted   +4 more
doaj   +1 more source

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Assessing California's Multiple Pathways Field [PDF]

, 2009
The multiple pathways approach to high school education combines rigorous academic learning and career skills to give students the intellectual and real-world experience to succeed in college, career and life.
Don Howard, Pat Wu
core  

Pathways to faceting of vesicles

, 2013
The interplay between geometry, topology and order can lead to geometric frustration that profoundly affects the shape and structure of a curved surface.
Bowick, Mark, Sknepnek, Rastko
core   +1 more source

External Evaluation of Event Extraction Classifiers for Automatic Pathway Curation: An extended study of the mTOR pathway [PDF]

arXiv, 2017
This paper evaluates the impact of various event extraction systems on automatic pathway curation using the popular mTOR pathway. We quantify the impact of training data sets as well as different machine learning classifiers and show that some improve the quality of automatically extracted pathways.
arxiv  

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Toll-Like Receptor Signaling Pathways

Frontiers in Immunology, 2014
Toll-like receptors (TLRs) play crucial roles in the innate immune system by recognizing pathogen-associated molecular patterns derived from various microbes. TLRs signal through the recruitment of specific adaptor molecules, leading to activation of the
Takumi Kawasaki, T. Kawai
semanticscholar   +1 more source