Results 151 to 160 of about 7,950,605 (408)

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Refining the Protein-Protein Interactome using Gene Expression Data [PDF]

arXiv, 2010
Proteins interact with other proteins within biological pathways, forming connected subgraphs in the protein-protein interactome (PPI). Proteins are often involved in multiple biological pathways which complicates interpretation of interactions between proteins.
arxiv  

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source

Pathway Toward an Infrared Interferometer [PDF]

arXiv, 2010
We propose a realistic pathway to satisfy two goals, thermal infrared studies of Earth-like exoplanets and interferometric architectures.
arxiv  

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Pathways: Augmenting interoperability across scholarly repositories

, 2006
In the emerging eScience environment, repositories of papers, datasets, software, etc., should be the foundation of a global and natively-digital scholarly communications system. The current infrastructure falls far short of this goal.
Carl Lagoze, H. Vande Sompel, Herbert Van de Warner, Jeroen Bekaert, Sandy Payette, Simeon Warner, Xiaoming Liu   +6 more
core   +1 more source

A CASE OF UNILATERAL BULBAR LESION, PROBABLY SYRINGOBULBIA, WITH SPECIAL REFERENCE TO THE SENSORY PATHWAYS WITHIN THE MEDULLA [PDF]

, 1923
W. G. Wyllie
openalex   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Pathways to Progress: A Tangible Impact on Youth Economic Opportunity [PDF]

, 2017
The inaugural Issue Brief, Pathways to Progress: Setting the Stage for Impact (June 2015), described the Citi Foundation's goals in each of these impact areas and early progress.

core  

EARLY AND LATE POST-TETANIC POTENTIATION, AND POST-TETANIC BLOCK IN A MONOSYNAPTIC REFLEX PATHWAY [PDF]

, 1959
David P. C. Lloyd
openalex   +1 more source