Results 61 to 70 of about 5,642,885 (289)

Metabolic regulation of regulatory T cell development and function [PDF]

, 2014
It is now well established that the effector T cell (Teff) response is regulated by a series of metabolic switches. Quiescent T cells predominantly require ATP-generating processes, whereas proliferating Teff require high metabolic flux through growth ...
Alves, Barbi, Battaglia, Bental, Borsellino, Carr, Cipolletta, Cobbold, Coloff, Cunningham, Curti, Cybulski, Dang, Deiuliis, Delgoffe, Delgoffe, Feuerer, Fisson, Fox, Frauwirth, GabryÅ¡ová, Greiner, Guertin, Guertin, Gulen, Hardie, Hardie, Howie, Hörig, Jacobs, Jones, Jordan, Kane, Lee, Lord, Makki, Matarese, Matteoli, Mellor, Metz, Michalek, Munder, Munder, Oh, Olefsky, Ouchi, Peter, Powell, Powell, Powell, Powell, Procaccini, Procaccini, Sakaguchi, Sarbassov, Shevach, Shi, Sitkovsky, Smith, Thornton, Vanasek, Vander Heiden, Vukmanovic-Stejic, Waickman, Wieman, Winer, Yang, Zeng, Zheng   +68 more
core   +2 more sources

Pathway Distiller - multisource biological pathway consolidation [PDF]

BMC Genomics, 2012
Abstract Background One method to understand and evaluate an experiment that produces a large set of genes, such as a gene expression microarray analysis, is to identify overrepresentation or enrichment for biological pathways.
Doderer, Mark S., Anguiano, Zachry, Suresh, Uthra, Dashnamoorthy, Ravi, Bishop, Alexander J. R., Chen, Yidong   +5 more
openaire   +4 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Adaptive modeling of biochemical pathways [PDF]

, 2010
In bioinformatics, biochemical pathways can be modeled by many differential equations. It is still an open problem how to fit the huge amount of parameters of the equations to the available data.
Brause, Rüdiger W.
core  

Pathways: Augmenting interoperability across scholarly repositories

, 2006
In the emerging eScience environment, repositories of papers, datasets, software, etc., should be the foundation of a global and natively-digital scholarly communications system. The current infrastructure falls far short of this goal.
Carl Lagoze, H. Vande Sompel, Herbert Van de Warner, Jeroen Bekaert, Sandy Payette, Simeon Warner, Xiaoming Liu   +6 more
core   +1 more source

Modelling and analysis of biochemical signalling pathway cross-talk [PDF]

, 2010
Signalling pathways are abstractions that help life scientists structure the coordination of cellular activity. Cross-talk between pathways accounts for many of the complex behaviours exhibited by signalling pathways and is often critical in producing ...
Emanuela Merelli, Muffy Calder, Paola Quaglia, Robin Donaldson   +3 more
core   +5 more sources

Metabolomics, Pathway Regulation, and Pathway Discovery [PDF]

Journal of Biological Chemistry, 2011
Metabolomics is a data-based research strategy, the aims of which are to identify biomarker pictures of metabolic systems and metabolic perturbations and to formulate hypotheses to be tested. It involves the assay by mass spectrometry or NMR of many metabolites present in the biological system investigated.
Guo-Fang, Zhang, Sushabhan, Sadhukhan, Gregory P, Tochtrop, Henri, Brunengraber   +3 more
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Innovating cultural studies pedagogy: a reflective case study of active and experiential learning in higher education

Frontiers in Education
This paper presents a reflective case study of a pedagogical innovation in teaching the Introduction to Southeast Asian Cultures and Societies Unit in a higher education institution.
Aiedah Abdul Khalek, Angeline Wei Wei Wong   +1 more
doaj   +1 more source

The association of intrauterine and postnatal growth patterns and nutritional status with toddler body composition

BMC Pediatrics, 2023
Background Growth patterns may be indicative of underlying changes in body composition. However, few studies have assessed the association of growth and body composition in poorly resourced regions experiencing the double-burden of malnutrition exists ...
Elizabeth Masiakwala, Lukhanyo H. Nyati, Shane A. Norris   +2 more
doaj   +1 more source