Results 71 to 80 of about 5,776,246 (295)

Perceived treatment burden and health-related quality of life in association with healthcare utilisation among patients attending multiple outpatient clinics

Health and Quality of Life Outcomes
Introduction Patients with multimorbidity who frequently require healthcare may experience a higher treatment burden. In this study, we investigated whether high perceived treatment burden and low perceived health-related quality of life (HRQoL) were ...
Cathrine Bell, Charlotte Weiling Appel, Asger Roer Pedersen, Peter Vedsted   +3 more
doaj   +1 more source

Leveraging capacity for transformative sustainability science: a theory of change from the Future Earth Pathways Initiative

Global Sustainability
Non-technical summary To address increasingly pressing social–environmental challenges, the transformative strand of sustainability science seeks to move beyond a descriptive-analytical stance in order to explore and contribute to the implementation of ...
Gilles Marciniak, Davnah Urbach, Flurina Schneider, Cornelia Krug, Ariane de Bremond, Mark Stafford-Smith, Odirilwe Selomane, Rebecca Fenn, Natalie Chong, Sandrine Paillard   +9 more
doaj   +1 more source

Non-vitamin K Antagonist Oral Anticoagulant, Warfarin, and ABC Pathway Adherence on Hierarchical Outcomes: Win Ratio Analysis of the COOL-AF Registry [PDF]

, 2023
Sukrit Treewaree, Gregory Y.H. Lip, Rungroj Krittayaphong   +2 more
openalex   +1 more source

CTLA-4 and PD-1 Pathways

American Journal of Clinical Oncology, 2016
The cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) and programmed death 1 (PD-1) immune checkpoints are negative regulators of T-cell immune function.
E. Buchbinder, Anupam M. Desai
semanticscholar   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Toll-Like Receptor Signaling Pathways

Frontiers in Immunology, 2014
Toll-like receptors (TLRs) play crucial roles in the innate immune system by recognizing pathogen-associated molecular patterns derived from various microbes. TLRs signal through the recruitment of specific adaptor molecules, leading to activation of the
Takumi Kawasaki, T. Kawai
semanticscholar   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Calcium Deficiency Rickets in African Adolescents: Cortical Bone Histomorphometry

JBMR Plus, 2019
Rickets due to dietary calcium deficiency has been well described in black African children, but less is known about this condition in black adolescents. We investigated 26 black adolescents (19 males aged 11 to 19 years and 7 females aged 12 to 15 years)
Christine M Schnitzler, John M Pettifor
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

A new scenario framework for climate change research: the concept of shared socioeconomic pathways

Climatic Change, 2014
The new scenario framework for climate change research envisions combining pathways of future radiative forcing and their associated climate changes with alternative pathways of socioeconomic development in order to carry out research on climate change ...
B. O’Neill, E. Kriegler, K. Riahi, K. Ebi, S. Hallegatte, T. Carter, R. Mathur, D. P. Vuuren   +7 more
semanticscholar   +1 more source