Results 71 to 80 of about 5,340,501 (369)
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
BMJ Global HealthIntroduction There is limited research on applying theory to retention in complex intervention trials. To address this gap, this study aimed to qualitatively examine retention in the Bukhali randomised controlled trial, from the perspective of trial ...
Shane A Norris +4 more
doaj +1 more source
Calcium Deficiency Rickets in African Adolescents: Cortical Bone Histomorphometry
JBMR Plus, 2019 Rickets due to dietary calcium deficiency has been well described in black African children, but less is known about this condition in black adolescents. We investigated 26 black adolescents (19 males aged 11 to 19 years and 7 females aged 12 to 15 years)
Christine M Schnitzler, John M Pettifor
doaj +1 more source
Techniques of Model Reductions in Biochemical Cell Signaling Pathways [PDF]
arXiv, 2021 There are many mathematical models of biochemical cell signaling pathways that contain a large number of elements (species and reactions). This is sometimes a big issue for identifying critical model elements and describing the model dynamics. Thus, techniques of model reduction can be used as a mathematical tool in order to minimize the number of ...
arxiv
Functional Integration of Ecological Networks through Pathway Proliferation [PDF]
Journal of Theoretical Biology 245: 98-111, 2006 Large-scale structural patterns commonly occur in network models of complex systems including a skewed node degree distribution and small-world topology. These patterns suggest common organizational constraints and similar functional consequences. Here, we investigate a structural pattern termed pathway proliferation.
arxiv +1 more source
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
Journal of Lipid Research, 2009 The nuclear receptor constitutive androstane receptor (CAR) (NR1I3) regulates hepatic genes involved in xenobiotic detoxification as well as genes involved in energy homeostasis.
Jodi M. Maglich +2 more
doaj
Predicting pathways for old and new metabolites through clustering [PDF]
arXiv, 2022 The diverse metabolic pathways are fundamental to all living organisms, as they harvest energy, synthesize biomass components, produce molecules to interact with the microenvironment, and neutralize toxins. While discovery of new metabolites and pathways continues, the prediction of pathways for new metabolites can be challenging.
arxiv
Modelling and Analysis of Biochemical Signalling Pathway Cross-talk [PDF]
EPTCS 19, 2010, pp. 40-54, 2010 Signalling pathways are abstractions that help life scientists structure the coordination of cellular activity. Cross-talk between pathways accounts for many of the complex behaviours exhibited by signalling pathways and is often critical in producing the correct signal-response relationship.
arxiv +1 more source
American Journal of Clinical Oncology, 2016 The cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) and programmed death 1 (PD-1) immune checkpoints are negative regulators of T-cell immune function.
E. Buchbinder, Anupam M. Desai
semanticscholar +1 more source