Results 121 to 130 of about 1,790,302 (324)

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Physical outcome measure for critical care patients following intensive care discharge [PDF]

, 2016
Introduction: The aim of this study was to evaluate the most suitable physical outcome measures to be used with critical care patients following discharge. ICU survivors experience physical problems such as reduced exercise capacity and intensive care
Daniel, M, Devine, H, Kinsella, J., MacTavish, P, McPeake, J., Quasim, T.   +5 more
core   +1 more source

Barriers and enablers to the implementation of patient-reported outcome and experience measures (PROMs/PREMs): protocol for an umbrella review

Systematic Reviews
Background Patient-reported outcome and experience measures (PROMs and PREMs, respectively) are evidence-based, standardized questionnaires that can be used to capture patients’ perspectives of their health and health care.
Guillaume Fontaine, Marie-Eve Poitras, Maxime Sasseville, Marie-Pascale Pomey, Jérôme Ouellet, Lydia Ould Brahim, Sydney Wasserman, Frédéric Bergeron, Sylvie D. Lambert   +8 more
doaj   +1 more source

Hospital healthcare experiences of children and young people with life-threatening or life-shortening conditions, and their parents: scoping reviews and resultant conceptual frameworks

BMC Pediatrics, 2023
Background Patient experience is a core component of healthcare quality. Patient-reported experience measures (PREMs) are increasingly used to assess this, but there are few paediatric PREMs.
Suzanne Mukherjee, Natalie Richardson, Bryony Beresford   +2 more
doaj   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

Examination of Acute Care Nurses Ability to Engage in Patient Education Related to Physical Activity as a Health Behavior [PDF]

, 2012
Physical activity is important for management and prevention of chronic disease. The current physical activity guidelines recommend engaging in physical activity for at least 30 minutes per day on at least 5 days a week.
Bayles, Constance, Hoffman, Leslie, Jakicic, John, Miketic, Joyce, Zewe, Gretchen/E   +4 more
core  

Strategies for incorporating patient-reported outcomes in the care of people with chronic kidney disease (PRO kidney): a protocol for a realist synthesis

Systematic Reviews, 2019
Background Patient-reported outcomes and experience measures (jointly referred to here as PROs) are internationally recognized as a means for patients to provide information about their quality of life, symptoms, and experiences with care.
Kara Schick-Makaroff, Onouma Thummapol, Stephanie Thompson, Rachel Flynn, Mehri Karimi-Dehkordi, Scott Klarenbach, Richard Sawatzky, Joanne Greenhalgh   +7 more
doaj   +1 more source

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

Molecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef, Hana Barhom, Sumit Chatterji, Netta Hecht, Oran Warhaftig, Iris Kamer, Oranit Zadok, Jair Bar, Limor Broday, Amir Onn, Michael Peled   +10 more
wiley   +1 more source

Are TKA kinematics during closed kinetic chain exercises associated with patient-reported outcomes? A preliminary analysis [PDF]

, 2020
BackgroundKinematic patterns after TKA can vary considerably from those of the native knee. It is unknown, however, if there is a relationship between a given kinematic pattern and patient satisfaction after TKA.Questions/purposesIs there an association ...
Van Der Straeten, Catherine, Van Eenoo, Wies, Van Onsem, Stefaan, Verstraete, Matthias, Victor, Jan   +4 more
core   +1 more source

Assessment of patient centredness through patient-reported experience measures (ASPIRED): protocol of a mixed-methods study

BMJ Open, 2018
Introduction The impact of patient centredness (PC) in healthcare has grown over the years. However, conceptualisations of PC are heterogeneous. Existing patient-reported measures of PC have shown inconsistencies and shortcomings.
E. Christalle, S. Zeh, Pola Hahlweg, L. Kriston, M. Härter, I. Scholl   +5 more
semanticscholar   +1 more source